| Title: | Analysis of the association between CD40 and CD40 ligand polymorphisms and systemic sclerosis. |
| Authors: | Teruel, María
Simeon, Carmen P
Broen, Jasper
Vonk, Madelon C
Carreira, Patricia
Camps, Maria Teresa
García-Portales, Rosa
Delgado-Frías, Esmeralda
Gallego, Maria
Espinosa, Gerard
Beretta, Lorenzo
Airó, Paolo
Lunardi, Claudio
Riemekasten, Gabriela
Witte, Torsten
Krieg, Thomas
Kreuter, Alexander
Distler, Jörg H W
Hunzelmann, Nicolas
Koeleman, Bobby P
Voskuyl, Alexandre E
Schuerwegh, Annemie J
González-Gay, Miguel Angel
Radstake, Timothy R D J
Martin, Javier |
| metadata.dc.contributor.authoraffiliation: | [Teruel,M; Martin,J] Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSICGranada, SpainArmilla (Granada), Spain. [Simeon,CP] Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain. [Broen,J; Vonk,MC] Department of Rheumatology, Radboud University Nijmegen Medical Centre,
Nijmegen, The Netherlands. [Carreira,P] Department of Rheumatology, Hospital 12 de Octubre, Madrid, Spain. [Camps,MT] Department of Internal Medicine, Hospital Carlos Haya, Málaga, Spain. [García-Portales,R] Department of Rheumatology, Hospital Virgen de la Victoria, Málaga, Spain. [Delgado-Frías,E] Department of Rheumatology, Hospital Universitario de Canarias, La Cuesta, San Cristóbal de La Laguna, Tenerife, Canarias, Spain. [Gallego,M] Department of Internal Medicine, Hospital Central de Asturias, Oviedo, Spain. [Espinosa,G] Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Spain. [Beretta,L] Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’Granda Ospedale Maggiore Policlinico. University of Milan, Milan, Italy. [Airó,P] Rheumatology Unit and Chair, Spedali Civili, Università degli Studi, Brescia, Italy. [Lunardi,C] Department of Medicine, Policlinico GB Rossi, Università degli studi di Verona, Verona, Italy. [Riemekasten,G] Department of Rheumatology and Clinical Immunology, Charité University Hospital and German Rheumatism Research Centre, a Leibniz Institute, Berlin, Germany. [Witte,T] Clinic for Immunology and Rheumatology Medical School, Hannover, Germany. [Krieg,T; Hunzelmann,N] Department of Dermatology, University of Cologne, Germany. [Kreuter,A] Department of Dermatology, Allergology, and Venereology, Ruhr University of Bochum, Bochum, Germany. [Distler,JHW] Department of Internal Medicine 3, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany. [Koeleman,BP] Section Complex Genetics, Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands. [Voskuy,AE] Department of Rheumatology, VU University Medical Center, Amsterdam, The Netherlands. [Schuerwegh,AJ] Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands. [González-Gay,MA] Department of Rheumatology, Hospital Universitario Marques de Valdecilla, IFIMAV, Santander, Spain. [Radstake,TRDJ] Department of Rheumatology and Clinical Immunology, University Utrecht Medical Center Utrecht, The Netherlands. |
| metadata.dc.contributor.group: | The Spanish Scleroderma Group |
| Keywords: | Ligando CD40;antígenos CD40;Predisposición genética a la enfermedad;Genotipo;Humanos;Polimorfismo de Nucleótido Simple;Esclerodermia sistémica |
| metadata.dc.subject.mesh: | Medical Subject Headings::Chemicals and Drugs::Biological Factors::Antigens::Antigens, Surface::Antigens, Differentiation::Antigens, CD::CD40 Ligand
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype::Genetic Predisposition to Disease
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic::Polymorphism, Single Nucleotide
Medical Subject Headings::Diseases::Skin and Connective Tissue Diseases::Skin Diseases::Scleroderma, Systemic
Medical Subject Headings::Chemicals and Drugs::Biological Factors::Antigens::Antigens, Surface::Antigens, Differentiation::Antigens, CD::Antigens, CD40 |
| Issue Date: | 25-Jun-2012 |
| Publisher: | BioMed Central |
| Citation: | Teruel M, Simeon CP, Broen J, Vonk MC, Carreira P, Camps MT, et al. Analysis of the association between CD40 and CD40 ligand polymorphisms and systemic sclerosis. Arthritis Res. Ther. 2012; 14(3):R154 |
| Abstract: | INTRODUCTION
The aim of the present study was to investigate the possible role of CD40 and CD40 ligand (CD40LG) genes in the susceptibility and phenotype expression of systemic sclerosis (SSc).
METHODS
In total, 2,670 SSc patients and 3,245 healthy individuals from four European populations (Spain, Germany, The Netherlands, and Italy) were included in the study. Five single-nucleotide polymorphisms (SNPs) of CD40 (rs1883832, rs4810485, rs1535045) and CD40LG (rs3092952, rs3092920) were genotyped by using a predesigned TaqMan allele-discrimination assay technology. Meta-analysis was assessed to determine whether an association exists between the genetic variants and SSc or its main clinical subtypes.
RESULTS
No evidence of association between CD40 and CD40LG genes variants and susceptibility to SSc was observed. Similarly, no significant statistical differences were observed when SSc patients were stratified by the clinical subtypes, the serologic features, and pulmonary fibrosis.
CONCLUSIONS
Our results do not suggest an important role of CD40 and CD40LG gene polymorphisms in the susceptibility to or clinical expression of SSc. |
| Description: | Journal Article; Research Support, Non-U.S. Gov't; |
| URI: | http://hdl.handle.net/10668/1410 |
| metadata.dc.relation.publisherversion: | http://arthritis-research.com/content/14/3/R154/abstract |
| metadata.dc.identifier.doi: | 10.1186/ar3890 |
| ISSN: | 1478-6362 (Online)
1478-6354 (Print) |
| Appears in Collections: | 01- Artículos - Hospital Regional de Málaga
01- Artículos - Hospital Virgen de la Victoria
|
