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Title: Gender differences in cardiovascular risk factors in HIV infected patients on antiretroviral therapy: Data from the Spanish Coronator study.
Authors: Santos, J
Olalla, J
Pérez-Elías, M
Miralles, C
Lozano, F
Iribarren, J
Masiá, M
Domingo, P
Bernardino, J
Estrada, V
metadata.dc.contributor.authoraffiliation: [Santos,J] Hospital Virgen de la Victoria, Málaga, Spain. [Olalla,J] Hospital Costa del Sol, Marbella, Spain. [Pérez Elías,M] Hospital Ramón y Cajal, Madrid, Spain. [Miralles,C] Hospital Xeral, Vigo, Spain. [Lozano,F] Hospital Valme, Sevilla, Spain. [Iribarren,J] Hospital Donostia, San Sebastián, Spain. [Masiá,M] Hospital de Elche, Elche, Spain. [Domingo,P] Hospital Sant Pau, Barcelona, Spain. [Bernardino,J] Hospital la Paz, Madrid, Spain. [Estrada,V] Hospital San Carlos, Madrid, Spain.
Keywords: Infecciones por VIH;Obesidad Abdominal;Síndrome de Inmunodeficiencia Adquirida;Antígenos CD4;HDL-Colesterol;Quimioterapia
metadata.dc.subject.mesh: Medical Subject Headings::Diseases::Virus Diseases::RNA Virus Infections::Retroviridae Infections::Lentivirus Infections::HIV Infections
Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity::Obesity, Abdominal
Medical Subject Headings::Diseases::Virus Diseases::RNA Virus Infections::Retroviridae Infections::Lentivirus Infections::HIV Infections::Acquired Immunodeficiency Syndrome
Medical Subject Headings::Chemicals and Drugs::Biological Factors::Antigens::Antigens, Surface::Antigens, Differentiation::Antigens, CD::Antigens, CD4
Medical Subject Headings::Chemicals and Drugs::Lipids::Lipoproteins::Lipoproteins, HDL::Cholesterol, HDL
Medical Subject Headings::Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Sex Characteristics
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy
Issue Date: 11-Nov-2012
Publisher: BioMed Central
Citation: Santos J., Olalla J., Pérez Elías M., Miralles C., Lozano F., Iribarren J. et al. Gender differences in cardiovascular risk factors in HIV infected patients on antiretroviral therapy: Data from the Spanish Coronator study. Journal of the International AIDS Society. 2012;15(Suppl. 4):18131.
Abstract: Purpose: HIV-infected patients present an increased cardiovascular risk (CVR) of multifactorial origin, usually lower in women than in men. Information by gender about prevalence of modifiable risk factors is scarce. Methods: Coronator is a cross-sectional survey of a representative sample of HIV-infected patients on ART within 10 hospitals across Spain in 2011. Variables include sociodemographics, CVR factors and 10-year CV disease risk estimation (Regicor: Framingham score adapted to the Spanish population). Results: We included 860 patients (76.3% male) with no history of CVD. Median age 45.6 years; 84.1% were Spaniards; 29.9% women were IDUs. Median time since HIV diagnosis for men and women was 10 and 13 years (p=0.001), 28% had an AIDS diagnosis. Median CD4 cell count was 596 cells/mm3, 88% had undetectable viral load. Median time on ART was 91 and 108 months (p=0.017). There was a family history of early CVD in 113 men (17.9%) and 41 women (20.6%). Classical CVR factors are described in the table. Median (IQR) Regicor Score was 3% (2-5) for men and 2% (1-3) for women (p=0.000), and the proportion of subjects with mid-high risk (>5%) was 26.1% for men and 9.4% for women (p=0.000). Conclusions: In this population of HIV-infected patients, women have lower cardiovascular risk than men, partly due to higher levels of HDL cholesterol. Of note is the high frequency of smoking, abdominal obesity and sedentary lifestyle in our population. (Table Presented).
Description: Abstract of the Eleventh International Congress on Drug Therapy in HIV Infection
metadata.dc.identifier.doi: 10.7448/IAS.15.6.18131
ISSN: 1758-2652 (Online)
Appears in Collections:01- Artículos - APES Costa del Sol
01- Artículos - Hospital de Valme
01- Artículos - Hospital Virgen de la Victoria

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