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Title: A nutritional intervention study with hydrolyzed collagen in pre-pubertal Spanish children: influence on bone modeling biomarkers
Authors: Martin-Bautista, Elena
Martin-Matillas, Miguel
Martin-Lagos, Jose A.
Miranda-Leon, M\ Teresa
Muñoz-Torres, Manuel
Ruiz-Requena, Estrella
Rivero, M.
Quer, Josefa
Puigdueta, Isabel
Campoy, Cristina
metadata.dc.contributor.authoraffiliation: [Martin-Bautista,E; Martin-Matillas,M; Martin-Lagos,JA; Campoy,C] Department of Pediatrics, School of Medicine. University of Granada, Granada, Spain. [Miranda-Leon,MT] Department of Biostatistics, School of Medicine, University of Granada, Granada, Spain. [Munoz-Torres,M] Service of Endocrinology, University Hospital San Cecilio, Granada, Spain. [Ruiz-Requena, E] Service of Biochemistry, University Hospital San Cecilio, Granada, Spain. [Rivero,M; Quer,J; Puigdueta, I]Grupo de Estudios en Nutrición y Alimentación-GENA, Barcelona, Spain.
Keywords: Bone;Children;Protein;Proteínas en la Dieta;Colágeno Tipo I;Marcadores Biológicos;Fosfatasa Alcalina;Niño;Remodelación Ósea;Proteínas en la Dieta;Pruebas de Química Clínica;Fuerza de la Mano;Dieta;Hidrólisis;Femenino;Masculino;Humano;España;Pubertad
metadata.dc.subject.mesh: Medical Subject Headings::Chemicals and Drugs::Biological Factors::Biological Markers
Medical Subject Headings::Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Musculoskeletal Physiological Processes::Bone Remodeling
Medical Subject Headings::Named Groups::Persons::Age Groups::Child
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Clinical Chemistry Tests
Medical Subject Headings::Chemicals and Drugs::Macromolecular Substances::Polymers::Biopolymers::Collagen::Fibrillar Collagens::Collagen Type I
Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet
Medical Subject Headings::Technology, Industry, Agriculture::Food and Beverages::Food::Dietary Proteins
Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Muscle Strength::Hand Strength
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Chemical Processes::Hydrolysis
Medical Subject Headings::Check Tags::Male
Medical Subject Headings::Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Puberty
Medical Subject Headings::Geographicals::Geographic Locations::Europe::Spain
Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Esterases::Phosphoric Monoester Hydrolases::Alkaline Phosphatase
Issue Date: Apr-2011
Publisher: Walter de Gruyter
Citation: Martin-Bautista E, Martin-Matillas M, Martin-Lagos JA, Miranda-Leon MT, Muñoz-Torres M, Ruiz-Requena E, et al. A nutritional intervention study with hydrolyzed collagen in pre-pubertal spanish children: influence on bone modeling biomarkers. J. Pediatr. Endocrinol. Metab. 2011; 24(3-4):147-53
Abstract: Aim: The aim of the study was to investigate the influence of dietary intake of commercial hydrolyzed collagen (Gelatine Royal ®) on bone remodeling in pre-pubertal children. Methods: A randomized double-blind study was carried out in 60 children (9.42 ± 1.31 years) divided into three groups according to the amount of partially hydrolyzed collagen taken daily for 4 months: placebo (G-I, n = 18), collagen (G-II, n = 20) and collagen + calcium (G-III, n = 22) groups. Analyses of the following biochemical markers were carried out: total and bone alkaline phosphatase (tALP and bALP), osteocalcin, tartrate-resistant acid phosphatase (TRAP), type I collagen carboxy terminal telopeptide, lipids, calcium, 25-hydroxyvitamin D, insulin-like growth factor 1 (IGF-1), thyroid-stimulating hormone, free thyroxin and intact parathormone. Results: There was a significantly greater increase in serum IGF-1 in G-III than in G II (p < 0.01) or G-I (p < 0.05) during the study period, and a significantly greater increase in plasma tALP in G-III than in G-I (p < 0.05). Serum bALP behavior significantly (p < 0.05) differed between G-II (increase) and G-I (decrease). Plasma TRAP behavior significantly differed between G-II and G-I (p < 0.01) and between G-III and G-II (p < 0.05). Conclusion: Daily dietary intake of hydrolyzed collagen seems to have a potential role in enhancing bone remodeling at key stages of growth and development.
Description: Journal Article; Randomized Controlled Trial.
metadata.dc.identifier.doi: 10.1515/JPEM.2011.009
ISSN: 2191-0251 (Online)
0334-018X (Print)
Appears in Collections:01- Artículos - Hospital San Cecilio

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