Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/1506
Título : Incidence of liver damage of uncertain origin in HIV patients not co-infected with HCV/HBV.
Autor : Rivero-Juárez, Antonio
Camacho, Angela
Merchante, Nicolás
Pérez-Camacho, Inés
Macias, Juan
Ortiz-Garcia, Carmen
Cifuentes, Celia
Torre-Cisneros, Julián
Peña, José
Pineda, Juan A
Rivero, Antonio
Filiación: [Rivero-Juarez, A; Camacho, A; Torre-Cisneros, J; Rivero, A] Infectious Diseases Unit, Instituto Maimonides de Investigacion Biomedica de Cordoba (IMIBIC), Hospital Universitario Reina Sofia, Cordoba, Spain. [Merchante, N; Macias, J; Cifuentes, C; Pineda, JA] Infectious Diseases Unit, Instituto de Investigacion Sanitaria de Sevilla (IBIS), Hospital Universitario de Valme, Sevilla, Spain. [Perez-Camacho,I] Internal Medicine Department, Hospital de Poniente, Almeria, Spain. [Ortiz-Garcia,C] Clinical Analysis Unit, Instituto Maimonides de Investigacion Biomedica de Cordoba (IMIBIC), Hospital Universitario Reina Sofia, Cordoba, Spain. [Peña,J] Immunology Unit, Instituto Maimonides de Investigacion Biomedica de Cordoba (IMIBIC), Hospital Universitario Reina Sofia, Cordoba, Spain.
Grupo de Investigación: Grupo para el estudio de las hepatitis viricas (HEPAVIR) de la Sociedad Andaluza de Enfermedades Infecciosas (SAEI)
Palabras clave : Análisis de la varianza
Hígado graso
Infecciones por VIH
Enfermedades hepáticas
Modelos logísticos
Estudios longitudinales
Incidencia
Estudios prospectivos
MeSH: Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Analysis of Variance
Medical Subject Headings::Diseases::Digestive System Diseases::Liver Diseases::Fatty Liver
Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Diseases::Immune System Diseases::Immunologic Deficiency Syndromes::HIV Infections
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Incidence
Medical Subject Headings::Diseases::Digestive System Diseases
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Regression Analysis::Logistic Models
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies
Medical Subject Headings::Check Tags
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective Studies
Medical Subject Headings::Health Care::Environment and Public Health::Public Health::Epidemiologic Factors::Causality::Risk Factors
Medical Subject Headings::Geographicals::Geographic Locations::Europe::Spain
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult
Fecha de publicación : 18-Jul-2013
Editorial : BioMed Central
Cita Bibliográfica: Rivero-Juárez A, Camacho A, Merchante N, Pérez-Camacho I, Macias J, Ortiz-Garcia C, et al. Incidence of liver damage of uncertain origin in HIV patients not co-infected with HCV/HBV. PLoS ONE; 8(7):e68953
Abstract: BACKGROUND AND AIMS Several studies have reported that a significant number of HIV patients not co-infected with HCV/HBV develop liver damage of uncertain origin (LDUO). The objective of our study was to evaluate the incidence of and risk factors for the development of LDUO in HIV infected patients not co-infected with HCV/HBV. METHODS Prospective longitudinal study that included HIV-infected patients free of previous liver damage and viral hepatitis B or C co-infections. Patients were followed up at 6-monthly intervals. Liver stiffness was measured at each visit. Abnormal liver stiffness (ALS) was defined as a liver stiffness value greater than 7.2 kPa at two consecutive measurements. For patients who developed ALS, a protocol was followed to diagnose the cause of liver damage. Those patients who could not be diagnosed with any specific cause of liver disease were diagnosed as LDUO and liver biopsy was proposed. RESULTS 210 patients matched the inclusion criteria and were included. 198 patients completed the study. After a median (Q1-Q3) follow-up of 18 (IQR 12-26) months, 21 patients (10.6%) developed ALS. Of these, fifteen patients were diagnosed as LDUO. The incidence of LDUO was 7.64 cases/100 patient-years. Histological studies were performed on ten (66.6%) patients and all showed liver steatosis. A higher HOMA-IR value and body mass index were independently associated with the development of LDUO. CONCLUSION We found a high incidence of LDUO in HIV-infected patients associated with metabolic risk factors. The leading cause of LDUO in our study was non-alcoholic fatty liver disease.
Descripción : Journal Article; Research Support, Non-U.S. Gov't;
URI: http://hdl.handle.net/10668/1506
Versión del editor : http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0068953
DOI: 10.1371/journal.pone.0068953
ISSN : 1932-6203 (Online)
Appears in Collections:01- Artículos - Hospital de Valme
01- Artículos - IBIS. Instituto de Biomedicina de Sevilla
01- Artículos - IMIBIC. Instituto Maimónides de Investigación Biomédica de Córdoba
01- Artículos - Hospital Reina Sofía
01- Artículos - APES Hospital de Poniente

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