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Title: Diets based on virgin olive oil or fish oil but not on sunflower oil prevent age-related alveolar bone resorption by mitochondrial-related mechanisms.
Authors: Bullón, Pedro
Battino, Maurizio
Varela-López, Alfonso
Pérez-López, Patricia
Granados-Principal, Sergio
Ramírez-Tortosa, María C
Ochoa, Julio J
Cordero, Mario D
González-Alonso, Adrián
Ramírez-Tortosa, César L
Rubini, Corrado
Zizzi, Antonio
Quiles, José L
metadata.dc.contributor.authoraffiliation: [Bullón,P] Department of Periodontology, Dental School, University of Sevilla, Sevilla, Spain.[Battino,M] Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche,Università Politecnica delle Marche, Ancona, Italia.[Varela-López,A; Pérez-López,P; Ochoa, JJ; González-Alonso,A; Quiles, JR] Institute of Nutrition and Food Technology “José Mataix Verdú”, Department of Physiology, University of Granada, Spain.[Granados-Principal,S; Ramírez-Tortosa,MC] Institute of Nutrition and Food Technology “José Mataix Verdú”, Department of Biochemistry and Molecular Biology II, University of Granada, Spain. [Cordero, MD] Departamento de Citología e Histología Normal y Patológica, Universidad de Sevilla, Spain. [Ramírez-Tortosa,CL] Department of Pathology,Complejo Hospitalario de Jaén, Spain. [Rubini,C; Zizzi,A] Scienze Biomediche Sanità Pubblica, Università Politecnica delle Marche, Ancona, Italia.
Keywords: Aging;Envejecimiento;Alveolar Bone;Hueso Alveolar;Diet;Dieta;Fatty Acids;Ácidos grasos;Periodontitis;Sunflower;Girasol;Vegetable Oils;Aceites vegetales;Animals;Animales;Resorción ósea;Dietary Fats;Grasas en la dieta;Aceites de pescado;Male;Masculino;Mitocondrias;Aceites vegetales;Rats;Ratas;Ratas Wistar;Proceso alveolar
metadata.dc.subject.mesh: Medical Subject Headings::Organisms::Eukaryota::Animals
Medical Subject Headings::Diseases::Musculoskeletal Diseases::Bone Diseases::Bone Resorption
Medical Subject Headings::Technology, Industry, Agriculture::Food and Beverages::Food::Dietary Fats::Dietary Fats, Unsaturated
Medical Subject Headings::Chemicals and Drugs::Lipids::Oils::Fish Oils
Medical Subject Headings::Check Tags::Male
Medical Subject Headings::Anatomy::Cells::Cellular Structures::Intracellular Space::Cytoplasm::Cytoplasmic Structures::Organelles::Mitochondria
Medical Subject Headings::Chemicals and Drugs::Lipids::Oils::Plant Oils
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Mole Rats
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats::Rats, Wistar
Medical Subject Headings::Anatomy::Musculoskeletal System::Skeleton::Bone and Bones::Skull::Facial Bones::Jaw::Alveolar Process
Issue Date: 16-Sep-2013
Publisher: Public Library of Science
Citation: Bullón P, Battino M, Varela-López A, Pérez-López P, Granados-Principal S, Ramírez-Tortosa MC, et al. Diets based on virgin olive oil or fish oil but not on sunflower oil prevent age-related alveolar bone resorption by mitochondrial-related mechanisms. PLoS ONE.2013; 8(9):e74234
Abstract: BACKGROUND/OBJECTIVES Aging enhances frequency of chronic diseases like cardiovascular diseases or periodontitis. Here we reproduced an age-dependent model of the periodontium, a fully physiological approach to periodontal conditions, to evaluate the impact of dietary fat type on gingival tissue of young (6 months old) and old (24 months old) rats. METHODS/FINDINGS Animals were fed life-long on diets based on monounsaturated fatty acids (MUFA) as virgin olive oil, n-6 polyunsaturated fatty acids (n-6PUFA), as sunflower oil, or n-3PUFA, as fish oil. Age-related alveolar bone loss was higher in n-6PUFA fed rats, probably as a consequence of the ablation of the cell capacity to adapt to aging. Gene expression analysis suggests that MUFA or n-3PUFA allowed mitochondria to maintain an adequate turnover through induction of biogenesis, autophagy and the antioxidant systems, and avoiding mitochondrial electron transport system alterations. CONCLUSIONS The main finding is that the enhanced alveolar bone loss associated to age may be targeted by an appropriate dietary treatment. The mechanisms involved in this phenomenon are related with an ablation of the cell capacity to adapt to aging. Thus, MUFA or n-3PUFA might allow mitochondrial maintaining turnover through biogenesis or autophagy. They might also be able to induce the corresponding antioxidant systems to counteract age-related oxidative stress, and do not inhibit mitochondrial electron transport chain. From the nutritional and clinical point of view, it is noteworthy that the potential treatments to attenuate alveolar bone loss (a feature of periodontal disease) associated to age could be similar to some of the proposed for the prevention and treatment of cardiovascular diseases, a group of pathologies recently associated with age-related periodontitis.
Description: Journal Article; Research Support, Non-U.S. Gov't;
metadata.dc.identifier.doi: 10.1371/journal.pone.0074234
ISSN: 1932-6203 (Online)
1932-6203 (Print)
Appears in Collections:01- Artículos - Complejo Hospitalario de Jaén

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