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Title: Minor compounds of olive oil have postprandial anti-inflammatory effects
Authors: Pacheco, Yolanda M
Bemúdez, Beatriz
López, Sergio
Abia, Rocío
Villar, José
Muriana, Francisco J G
metadata.dc.contributor.authoraffiliation: [Pacheco,YM; Bemúdez,B; López,S; Abia,R; Muriana,FJG] Cellular and Molecular Nutrition, Instituto de la Grasa, CSIC, Seville, Spain. [Villar,J] Department of Internal Medicine, Hospitales Universitarios Virgen del Rocío, Seville, Spain.
Keywords: Postprandial metabolism;Adhesion molecules;Hypertriacylglycerolaemia;Olive oil;Antioxidantes;Estudios Cruzados;Molécula 1 de Adhesión Intercelular;Dieta Alta en Grasa;Oligopéptidos;Estrés Oxidativo;Aceites Vegetales;Periodo Posprandial;Molécula 1 de Adhesión Celular Vascular;Adulto Joven
metadata.dc.subject.mesh: Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Inflammatory Agents
Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Protective Agents::Antioxidants
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Research Design::Cross-Over Studies
Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet::Diet, High-Fat
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Glycoproteins::Membrane Glycoproteins::Cell Adhesion Molecules::Intercellular Adhesion Molecule-1
Medical Subject Headings::Check Tags::Male
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Oligopeptides
Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Oxidative Stress
Medical Subject Headings::Chemicals and Drugs::Lipids::Oils::Plant Oils
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Phenols::Polyphenols
Medical Subject Headings::Phenomena and Processes::Digestive System and Oral Physiological Phenomena::Digestive System Physiological Phenomena::Postprandial Period
Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Benzopyrans::Vitamin E::Tocopherols
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Glycoproteins::Membrane Glycoproteins::Cell Adhesion Molecules::Vascular Cell Adhesion Molecule-1
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Young Adult
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult
Issue Date: Aug-2007
Publisher: Cambridge University Press
Citation: Pacheco YM, Bemúdez B, López S, Abia R, Villar J, Muriana FJ. Minor compounds of olive oil have postprandial anti-inflammatory effects. Br. J. Nutr.. 2007; 98(2):260-3
Abstract: High postprandial levels of TAG may further induce endothelial dysfunction and inflammation in subjects with high fasting levels of TAG, an effect that seems to be related to oxidative stress. The present study investigated whether minor compounds of olive oil with antioxidant activity decrease postprandial levels of soluble isoforms of intercellular adhesion molecule 1 (sICAM-1) and vascular cell adhesion molecule 1 (sVCAM-1), as surrogate markers of vascular inflammation, after a high-fat meal. A randomized crossover and blind trial on fourteen healthy and fourteen hypertriacylglycerolaemic subjects was performed. The study involved a 1-week adaptation lead-in period on a National Cholesterol Education Program Step I diet supplemented with extra-virgin olive oil (EVOO) containing 1125 mg polyphenols/kg and 350 mg tocopherols/kg, or refined olive oil (ROO) with no polyphenols or tocopherols. After a 12 h fast, the participants ate a high-fat meal enriched in EVOO or ROO (50 g/m2 body surface area), which on average provided 3700 kJ energy with a macronutrient profile of 72% fat, 22% carbohydrate and 6% protein. Blood samples drawn hourly over the following 8 h demonstrated a similar postprandial TAG response for both EVOO and ROO meals. However, in both healthy and hypertriacylglycerolaemic subjects the net incremental area under the curve for sICAM-1 and sVCAM-1 were significantly lower after the EVOO meal. In conclusion,the consumption of EVOO with a high content of minor antioxidant compounds may have postprandial anti-inflammatory protective effects.
Description: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't;
metadata.dc.identifier.doi: 10.1017/S0007114507701666
ISSN: 0007-1145 (Print)
1475-2662 (Online)
Appears in Collections:01- Artículos - Hospital Virgen del Rocío

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