Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/1695
Título : The rise of soluble TWEAK levels in severely obese subjects after bariatric surgery may affect adipocyte-cytokine production induced by TNFα.
Autor : Maymó-Masip, Elsa
Fernández-Veledo, Sonia
García España, Antonio
Vázquez-Carballo, Ana
Tinahones, Francisco José
García-Fuentes, Eduardo
Garrifo-Sánchez, Lourdes
Rodríguez, María del Mar
Vendrell, Joan
Chacón, Matilde R
Filiación: [Maymó-Masip,E; Fernández-Veledo,S; Vázquez-Carballo,A; Garrifo-Sánchez,L; Vendrell,J; Chacón,MR] Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Madrid, Spain. [Maymó-Masip,E; Fernández-Veledo,S; García-España,A; Garrifo-Sánchez,L; Vendrell,J; Chacón,MR] Hospital Universitari de Tarragona Joan XXIII, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Madrid, Spain. [Vázquez-Carballo,A] Department of Biochemistry and Molecular Biology II, Faculty of Pharmacy, Complutense University, Madrid, Spain. [Tinahones,FJ; García-Fuentes,E; Rodríguez,M del M] Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad/Nutrición, Hospital Virgen de la Victoria, Málaga, Spain. [Tinahones,FJ] Department of Obesity and Nutrition, Hospital Virgen de la Victoria, Málaga, Spain. [García-Fuentes,E] Servicio de Endocrinología y Nutrición, Hospital Regional, Universitario Carlos Haya, Málaga, Spain. [García-Fuentes,E] Instituto de Investigaciones Biomédicas de Málaga, Spain. [Rodríguez,M del M] Department of Diabetes, Endocrinology, and Nutrition, Institut d'Investigació Biomèdica de Girona, Spain.
Palabras clave : Cirugía bariátrica
Índice de masa corporal
Citocinas
Ácidos grasos no esterificados
Macrófagos
Obesidad
Factor de necrosis tumoral alfa
Factores de necrosis tumoral
Adipocitos
MeSH: Medical Subject Headings::Named Groups::Persons::Age Groups::Adult
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Bariatric Surgery
Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Mass Index
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines
Medical Subject Headings::Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids, Nonesterified
Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Anatomy::Cells::Connective Tissue Cells::Macrophages
Medical Subject Headings::Check Tags::Male
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged
Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Tumor Necrosis Factors::Tumor Necrosis Factor-alpha
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Tumor Necrosis Factors
Medical Subject Headings::Anatomy::Cells::Connective Tissue Cells::Adipocytes
Fecha de publicación : Aug-2013
Editorial : Endocrine Society
Cita Bibliográfica: Maymó-Masip E, Fernández-Veledo S, García España A, Vázquez-Carballo A, Tinahones FJ, García-Fuentes E, et al. The rise of soluble TWEAK levels in severely obese subjects after bariatric surgery may affect adipocyte-cytokine production induced by TNFα. J Clin Endocrinol Metab. 2013; 98(8):E1323-33
Abstract: CONTEXT Soluble TNF-like weak inducer of apoptosis (sTWEAK) is generated by the intracellular proteolytic cleavage of full-length membrane-bound TNF-like weak inducer of apoptosis (mTWEAK). sTWEAK levels are reduced in diseases with an inflammatory component. Additionally, sTWEAK hampers TNFα activity in human cells. OBJECTIVES The objectives of the study were as follows: 1) to determine circulating sTWEAK in severe obesity and after bariatric surgery; 2) to study m/sTWEAK and its receptor fibroblast growth factor-inducible 14 (Fn14) protein expression in sc adipose tissue (SAT) of severely obese subjects, in SAT stromal vascular fraction (SVF), and isolated adipocytes and in human monocyte-derived macrophages; and 3) to explore, on human adipocytes, the sTWEAK effect on TNFα proinflammatory activity. DESIGN sTWEAK levels were measured in cohort 1: severely obese subjects (n = 23) and a control group (n = 35); and in cohort 2: (n = 23) severely obese subjects before and after surgery. The m/sTWEAK and Fn14 expressions were determined in SAT biopsies, SVF, and isolated adipocytes from severely obese and control subjects and in human monocyte-derived macrophages. In human primary cultured adipocytes, sTWEAK pretreated and TNFα challenged, IL-6, IL-8, and adiponectin protein and gene expressions were determined and nuclear factor-κ B and MAPK signaling analyzed. RESULTS sTWEAK levels were reduced in severely obese subjects. After surgery, sTWEAK levels rose in 69% of patients. mTWEAK protein expression was increased in SAT and SVF of severely obese subjects, whereas Fn14 was up-regulated in isolated adipocytes. M2 human monocyte-derived macrophages overexpress mTWEAK. In human adipocytes, sTWEAK down-regulates TNFα cytokine production by hampering TNFα intracellular signaling events. CONCLUSION The decrease of sTWEAK in severely obese patients may favor the proinflammatory activity elicited by TNFα.
Descripción : Journal Article; Research Support, Non-U.S. Gov't;
URI: http://hdl.handle.net/10668/1695
Versión del editor : http://press.endocrine.org/doi/abs/10.1210/jc.2012-4177?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
DOI: 10.1210/jc.2012-4177
ISSN : 1945-7197 (Online)
0021-972X (Print)
Appears in Collections:01- Artículos - IBIMA. Instituto de Investigación Biomédica de Málaga
01- Artículos - Hospital Regional de Málaga
01- Artículos - Hospital Virgen de la Victoria

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