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Title: Angiogenesis-related gene expression profile with independent prognostic value in advanced ovarian carcinoma.
Authors: Mendiola, Marta
Barriuso, Jorge
Redondo, Andrés
Mariño-Enríquez, Adrián
Madero, Rosario
Espinosa, Enrique
Fresno Vara, Juan Angel
Sánchez-Navarro, Iker
Hernández-Cortes, Ginés
Zamora, Pilar
Pérez-Fernández, Elia
Miguel-Martín, María
Suárez, Asunción
Palacios, José
González-Barón, Manuel
Hardisson, David
metadata.dc.contributor.authoraffiliation: [Mendiola,M; Mariño-Enríquez,A; Miguel-Martín,M; Suárez,A; Hardisson,D] Department of Pathology, Hospital Universitario La Paz, Universidad Autónoma de Madrid, Madrid, Spain. [Barriuso,J; Redondo,A; Espinosa,E; Zamora,P; González-Barón,M] Translational Oncology Unit, Hospital Universitario La Paz, Universidad Autónoma de Madrid, Madrid, Spain. [Madero,R; Pérez-Fernández,E] Unit of Biostatistics, Hospital Universitario La Paz, Universidad Autónoma de Madrid, Madrid, Spain. [Mendiola,M; Barriuso,J; Madero,R; Fresno Vara,JA; Sánchez-Navarro,I; Pérez-Fernández,E; Miguel-Martín,M] Fundación para la Investigación Biomédica del Hospital Universitario La Paz (FIBHULP), Madrid, Spain. [Hernández-Cortes,G; Palacios,J] Department of Pathology, Hospital Universitario Vírgen del Rocío, Sevilla, Spain.
Keywords: Anciano;Anciano de 80 o más Años;Carcinoma;Femenino;Perfilación de la Expresión Génica;Regulación Neoplásica de la Expresión Génica;Humanos;Análisis Multivariante;Neoplasias Ováricas;Pronóstico;ARN;Neovascularización patológica
metadata.dc.subject.mesh: Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Aged
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Aged::Aged, 80 and over
Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Glandular and Epithelial::Carcinoma
Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Gene Expression Profiling
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Gene Expression Regulation, Neoplastic
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Analysis of Variance::Multivariate Analysis
Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Endocrine Gland Neoplasms::Ovarian Neoplasms
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis
Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::RNA
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Metaplasia::Neovascularization, Pathologic
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged
Issue Date: 29-Dec-2008
Publisher: Public Library of Science
Citation: Mendiola M, Barriuso J, Redondo A, Mariño-Enríquez A, Madero R, Espinosa E, et al. Angiogenesis-related gene expression profile with independent prognosticvalue in advanced ovarian carcinoma. Plos One; 2008; 3(12):e40518
Abstract: BACKGROUND Ovarian carcinoma is the most important cause of gynecological cancer-related mortality in Western societies. Despite the improved median overall survival in patients receiving chemotherapy regimens such as paclitaxel and carboplatin combination, relapse still occurs in most advanced diseased patients. Increased angiogenesis is associated with rapid recurrence and decreased survival in ovarian cancer. This study was planned to identify an angiogenesis-related gene expression profile with prognostic value in advanced ovarian carcinoma patients. METHODOLOGY/PRINCIPAL FINDINGS RNAs were collected from formalin-fixed paraffin-embedded samples of 61 patients with III/IV FIGO stage ovarian cancer who underwent surgical cytoreduction and received a carboplatin plus paclitaxel regimen. Expression levels of 82 angiogenesis related genes were measured by quantitative real-time polymerase chain reaction using TaqMan low-density arrays. A 34-gene-profile which was able to predict the overall survival of ovarian carcinoma patients was identified. After a leave-one-out cross validation, the profile distinguished two groups of patients with different outcomes. Median overall survival and progression-free survival for the high risk group was 28.3 and 15.0 months, respectively, and was not reached by patients in the low risk group at the end of follow-up. Moreover, the profile maintained an independent prognostic value in the multivariate analysis. The hazard ratio for death was 2.3 (95% CI, 1.5 to 3.2; p<0.001). CONCLUSIONS/SIGNIFICANCE It is possible to generate a prognostic model for advanced ovarian carcinoma based on angiogenesis-related genes using formalin-fixed paraffin-embedded samples. The present results are consistent with the increasing weight of angiogenesis genes in the prognosis of ovarian carcinoma.
Description: Journal Article; Research Support, Non-U.S. Gov't;
metadata.dc.identifier.doi: 10.1371/journal.pone.0004051
ISSN: 1932-6203 (Online)
Appears in Collections:01- Artículos - Hospital Virgen del Rocío

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