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http://hdl.handle.net/10668/1797| Title: | Gene-lifestyle interaction and type 2 diabetes: the EPIC interact case-cohort study. |
| Authors: | Langenberg, Claudia Sharp, Stephen J Franks, Paul W Scott, Robert A Deloukas, Panos Forouhi, Nita G Froguel, Philippe Groop, Leif C Hansen, Torben Palla, Luigi Pedersen, Oluf Schulze, Matthias B Tormo, Maria-Jose Wheeler, Eleanor Agnoli, Claudia Arriola, Larraitz Barricarte, Aurelio Boeing, Heiner Clarke, Geraldine M Clavel-Chapelon, Françoise Duell, Eric J Fagherazzi, Guy Kaaks, Rudolf Kerrison, Nicola D Key, Timothy J Khaw, Kay Tee Kröger, Janine Lajous, Martin Morris, Andrew P Navarro, Carmen Nilsson, Peter M Overvad, Kim Palli, Domenico Panico, Salvatore Quirós, J Ramón Rolandsson, Olov Sacerdote, Carlotta Sánchez, María-José Slimani, Nadia Spijkerman, Annemieke M W Tumino, Rosario van der A, Daphne L van der Schouw, Yvonne T Barroso, Inês McCarthy, Mark I Riboli, Elio Wareham, Nicholas J |
| metadata.dc.contributor.authoraffiliation: | [Langenberg,C; Sharp,SJ; Scott,RA; Forouhi,NG; Palla,L; Kerrison,ND; Wareham,NJ] Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom. [Franks,PW; Nilsson,PM; Lund University, Malmö, Sweden. [Franks,PW; Rolandsson,O] Umea University, Umea, Sweden. [Deloukas,P; Wheeler,E; Barroso,I] The Wellcome Trust Sanger Institute, Cambridge, United Kingdom. [Froguel,P] Imperial College London, London, United Kingdom. [Groop,LC] University Hospital Scania, Malmö, Sweden. [Groop,LC] Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland. [Hansen,T; Pedersen,O] The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. [Hansen,T] Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark. [Pedersen,O] Faculty of Health Science, University of Aarhus, Aarhus, Denmark. [Pedersen,O] Institute of Biomedical Science, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark. [Schulze,MB; Boeing,H; Kröger,J] German Institute of Human Nutrition, Potsdam-Rehbruecke, Germany. [Tormo,M; Navarro,C] Department of Epidemiology, Murcia Regional Health Council, Murcia, Spain. [Tormo,M; Arriola,L; Barricarte,A; Navarro,C; Sánchez, M] Consorcio de Investigación Biomédica de Epidemiología y Salud Pública, Instituto de Salud Carlos III, Madrid, Spain. [Tormo,M] Department of Health and Social Sciences, Universidad de Murcia, Spain. [Agnoli,C] Epidemiology and Prevention Unit, Milan, Italy. [Arriola,L] Public Health Division of Gipuzkoa, San Sebastian, Spain. [Arriola,L] Instituto de Investigación Sanitaria BioDonostia, Basque Government, San Sebastian, Spain. [Barricarte,A] Navarre Public Health Institute, Pamplona, Spain. [Clarke,GM; Morris,AP; McCarthy,MI] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom. [Clavel-Chapelon,F; Fagherazzi,G; Lajous,M] Inserm, Villejuif, France. [Clavel-Chapelon,F; Fagherazzi,G] Université Paris-Sud, Villejuif, France. [Duel,EJ] Catalan Institute of Oncology, Bellvitge Biomedical Research Institute, Barcelona, Spain. [Kaaks,R] German Cancer Research Center, Heidelberg, Germany. [Key,TJ] University of Oxford, Oxford, United Kingdom. [Khaw,KT] University of Cambridge, Cambridge, United Kingdom. [Lajous,M] Center for Research on Population Health, National Institute of Public Health of Mexico, Cuernavaca, Mexico. [Lajous,M] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America. [Navarro,C] Unit of Preventive Medicine and Public Health, School of Medicine, University of Murcia, Murcia, Spain. [Overvad,K] Department of Public Health, Aarhus University, Aarhus, Denmark. Aalborg University Hospital, Aalborg, Denmark. [Palli,D] Cancer Research and Prevention Institute, Florence, Italy. [Panico,S] Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy. [Quirós,JR] Public Health Directorate, Asturias, Spain. [Sacerdote,C] Unit of Cancer Epidemiology, Azienda Ospedaliero Universitaria Citta` della Salute e della Scienza, University of Turin, Turin, Italy. Piedmont Reference Center for Epidemiology and Cancer Prevention, Torino, Italy. Human Genetics Foundation, Torino, Italy. [Sánchez,M] Andalusian School of Public Health, Granada, Spain. [Slimani,N] International Agency for Research on Cancer, Lyon, France. [Spijkerman,MW; A,DL] National Institute for Public Health and the Environment, Bilthoven, The Netherlands. [Tumino,R] Azienda Sanitaria Provinciale di Ragusa, Ragusa, Italy. Azienda Sanitaria Provinciale di Ragusa, Ragusa, Italy. [Schouw,YT] University Medical Center Utrecht, Utrecht, The Netherlands. [Barroso,I] University of Cambridge Metabolic Research Laboratories, Cambridge, United Kingdom. [McCarthy,MI] Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, United Kingdom. [McCarthy,MI] NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom. [Riboli,E] School of Public Health, Imperial College London, London, United Kingdom. |
| Keywords: | Alelos;Índice de Masa Corporal;Estudios de Cohortes;Diabetes Mellitus Tipo 2;Dieta Mediterránea;Femenino;Predisposición Genética a la Enfermedad;Humanos;Estilo de Vida;Masculino;Mediana Edad;Actividad Motora;Polimorfismo de Nucleótido Simple;Modelos de Riesgos Proporcionales;Factores de Riesgo;Circunferencia de la Cintura |
| metadata.dc.subject.mesh: | Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Alleles Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Body Constitution::Body Weights and Measures::Body Mass Index Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus::Diabetes Mellitus, Type 2 Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Nutrition Therapy::Diet Therapy::Diet, Mediterranean Medical Subject Headings::Check Tags::Female Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Susceptibility::Genetic Predisposition to Disease Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Psychology, Social::Life Style Medical Subject Headings::Check Tags::Male Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Motor Activity Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic::Polymorphism, Single Nucleotide Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models, Statistical::Proportional Hazards Models Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Body Constitution::Body Weights and Measures::Body Size::Waist Circumference |
| Issue Date: | 20-May-2014 |
| Publisher: | Public Library of Science |
| Citation: | Langenberg C, Sharp SJ, Franks PW, Scott RA, Deloukas P, Forouhi NG, et al. Gene-lifestyle interaction and type 2 diabetes: the EPIC interact case-cohort study. PLoS Med.. 2014 ; 11(5):e1001647 |
| Abstract: | BACKGROUND Understanding of the genetic basis of type 2 diabetes (T2D) has progressed rapidly, but the interactions between common genetic variants and lifestyle risk factors have not been systematically investigated in studies with adequate statistical power. Therefore, we aimed to quantify the combined effects of genetic and lifestyle factors on risk of T2D in order to inform strategies for prevention. METHODS AND FINDINGS The InterAct study includes 12,403 incident T2D cases and a representative sub-cohort of 16,154 individuals from a cohort of 340,234 European participants with 3.99 million person-years of follow-up. We studied the combined effects of an additive genetic T2D risk score and modifiable and non-modifiable risk factors using Prentice-weighted Cox regression and random effects meta-analysis methods. The effect of the genetic score was significantly greater in younger individuals (p for interaction = 1.20×10-4). Relative genetic risk (per standard deviation [4.4 risk alleles]) was also larger in participants who were leaner, both in terms of body mass index (p for interaction = 1.50×10-3) and waist circumference (p for interaction = 7.49×10-9). Examination of absolute risks by strata showed the importance of obesity for T2D risk. The 10-y cumulative incidence of T2D rose from 0.25% to 0.89% across extreme quartiles of the genetic score in normal weight individuals, compared to 4.22% to 7.99% in obese individuals. We detected no significant interactions between the genetic score and sex, diabetes family history, physical activity, or dietary habits assessed by a Mediterranean diet score. CONCLUSIONS The relative effect of a T2D genetic risk score is greater in younger and leaner participants. However, this sub-group is at low absolute risk and would not be a logical target for preventive interventions. The high absolute risk associated with obesity at any level of genetic risk highlights the importance of universal rather than targeted approaches to lifestyle intervention. |
| Description: | Journal Article; Research Support, Non-U.S. Gov't; |
| URI: | http://hdl.handle.net/10668/1797 |
| metadata.dc.relation.publisherversion: | http://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1001647 |
| metadata.dc.identifier.doi: | 10.1371/journal.pmed.1001647 |
| ISSN: | 1549-1676 (Online) 1549-1277 (Print) |
| Appears in Collections: | 01- Artículos - EASP. Escuela Andaluza de Salud Pública |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| Langenberg_Gene-LifestileIntervention.pdf | 1,03 MB | Adobe PDF | View/Open |
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