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Título : Gene-lifestyle interaction and type 2 diabetes: the EPIC interact case-cohort study.
Autor : Langenberg, Claudia
Sharp, Stephen J
Franks, Paul W
Scott, Robert A
Deloukas, Panos
Forouhi, Nita G
Froguel, Philippe
Groop, Leif C
Hansen, Torben
Palla, Luigi
Pedersen, Oluf
Schulze, Matthias B
Tormo, Maria-Jose
Wheeler, Eleanor
Agnoli, Claudia
Arriola, Larraitz
Barricarte, Aurelio
Boeing, Heiner
Clarke, Geraldine M
Clavel-Chapelon, Françoise
Duell, Eric J
Fagherazzi, Guy
Kaaks, Rudolf
Kerrison, Nicola D
Key, Timothy J
Khaw, Kay Tee
Kröger, Janine
Lajous, Martin
Morris, Andrew P
Navarro, Carmen
Nilsson, Peter M
Overvad, Kim
Palli, Domenico
Panico, Salvatore
Quirós, J Ramón
Rolandsson, Olov
Sacerdote, Carlotta
Sánchez, María-José
Slimani, Nadia
Spijkerman, Annemieke M W
Tumino, Rosario
van der A, Daphne L
van der Schouw, Yvonne T
Barroso, Inês
McCarthy, Mark I
Riboli, Elio
Wareham, Nicholas J
Filiación: [Langenberg,C; Sharp,SJ; Scott,RA; Forouhi,NG; Palla,L; Kerrison,ND; Wareham,NJ] Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom. [Franks,PW; Nilsson,PM; Lund University, Malmö, Sweden. [Franks,PW; Rolandsson,O] Umea University, Umea, Sweden. [Deloukas,P; Wheeler,E; Barroso,I] The Wellcome Trust Sanger Institute, Cambridge, United Kingdom. [Froguel,P] Imperial College London, London, United Kingdom. [Groop,LC] University Hospital Scania, Malmö, Sweden. [Groop,LC] Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland. [Hansen,T; Pedersen,O] The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. [Hansen,T] Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark. [Pedersen,O] Faculty of Health Science, University of Aarhus, Aarhus, Denmark. [Pedersen,O] Institute of Biomedical Science, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark. [Schulze,MB; Boeing,H; Kröger,J] German Institute of Human Nutrition, Potsdam-Rehbruecke, Germany. [Tormo,M; Navarro,C] Department of Epidemiology, Murcia Regional Health Council, Murcia, Spain. [Tormo,M; Arriola,L; Barricarte,A; Navarro,C; Sánchez, M] Consorcio de Investigación Biomédica de Epidemiología y Salud Pública, Instituto de Salud Carlos III, Madrid, Spain. [Tormo,M] Department of Health and Social Sciences, Universidad de Murcia, Spain. [Agnoli,C] Epidemiology and Prevention Unit, Milan, Italy. [Arriola,L] Public Health Division of Gipuzkoa, San Sebastian, Spain. [Arriola,L] Instituto de Investigación Sanitaria BioDonostia, Basque Government, San Sebastian, Spain. [Barricarte,A] Navarre Public Health Institute, Pamplona, Spain. [Clarke,GM; Morris,AP; McCarthy,MI] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom. [Clavel-Chapelon,F; Fagherazzi,G; Lajous,M] Inserm, Villejuif, France. [Clavel-Chapelon,F; Fagherazzi,G] Université Paris-Sud, Villejuif, France. [Duel,EJ] Catalan Institute of Oncology, Bellvitge Biomedical Research Institute, Barcelona, Spain. [Kaaks,R] German Cancer Research Center, Heidelberg, Germany. [Key,TJ] University of Oxford, Oxford, United Kingdom. [Khaw,KT] University of Cambridge, Cambridge, United Kingdom. [Lajous,M] Center for Research on Population Health, National Institute of Public Health of Mexico, Cuernavaca, Mexico. [Lajous,M] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America. [Navarro,C] Unit of Preventive Medicine and Public Health, School of Medicine, University of Murcia, Murcia, Spain. [Overvad,K] Department of Public Health, Aarhus University, Aarhus, Denmark. Aalborg University Hospital, Aalborg, Denmark. [Palli,D] Cancer Research and Prevention Institute, Florence, Italy. [Panico,S] Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy. [Quirós,JR] Public Health Directorate, Asturias, Spain. [Sacerdote,C] Unit of Cancer Epidemiology, Azienda Ospedaliero Universitaria Citta` della Salute e della Scienza, University of Turin, Turin, Italy. Piedmont Reference Center for Epidemiology and Cancer Prevention, Torino, Italy. Human Genetics Foundation, Torino, Italy. [Sánchez,M] Andalusian School of Public Health, Granada, Spain. [Slimani,N] International Agency for Research on Cancer, Lyon, France. [Spijkerman,MW; A,DL] National Institute for Public Health and the Environment, Bilthoven, The Netherlands. [Tumino,R] Azienda Sanitaria Provinciale di Ragusa, Ragusa, Italy. Azienda Sanitaria Provinciale di Ragusa, Ragusa, Italy. [Schouw,YT] University Medical Center Utrecht, Utrecht, The Netherlands. [Barroso,I] University of Cambridge Metabolic Research Laboratories, Cambridge, United Kingdom. [McCarthy,MI] Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, United Kingdom. [McCarthy,MI] NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom. [Riboli,E] School of Public Health, Imperial College London, London, United Kingdom.
Palabras clave : Alelos
Índice de Masa Corporal
Estudios de Cohortes
Diabetes Mellitus Tipo 2
Dieta Mediterránea
Femenino
Predisposición Genética a la Enfermedad
Humanos
Estilo de Vida
Masculino
Mediana Edad
Actividad Motora
Polimorfismo de Nucleótido Simple
Modelos de Riesgos Proporcionales
Factores de Riesgo
Circunferencia de la Cintura
MeSH: Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Alleles
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Body Constitution::Body Weights and Measures::Body Mass Index
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies
Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus::Diabetes Mellitus, Type 2
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Nutrition Therapy::Diet Therapy::Diet, Mediterranean
Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Susceptibility::Genetic Predisposition to Disease
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Psychology, Social::Life Style
Medical Subject Headings::Check Tags::Male
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged
Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Motor Activity
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic::Polymorphism, Single Nucleotide
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models, Statistical::Proportional Hazards Models
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Body Constitution::Body Weights and Measures::Body Size::Waist Circumference
Fecha de publicación : 20-may-2014
Editorial : Public Library of Science
Cita Bibliográfica: Langenberg C, Sharp SJ, Franks PW, Scott RA, Deloukas P, Forouhi NG, et al. Gene-lifestyle interaction and type 2 diabetes: the EPIC interact case-cohort study. PLoS Med.. 2014 ; 11(5):e1001647
Abstract: BACKGROUND Understanding of the genetic basis of type 2 diabetes (T2D) has progressed rapidly, but the interactions between common genetic variants and lifestyle risk factors have not been systematically investigated in studies with adequate statistical power. Therefore, we aimed to quantify the combined effects of genetic and lifestyle factors on risk of T2D in order to inform strategies for prevention. METHODS AND FINDINGS The InterAct study includes 12,403 incident T2D cases and a representative sub-cohort of 16,154 individuals from a cohort of 340,234 European participants with 3.99 million person-years of follow-up. We studied the combined effects of an additive genetic T2D risk score and modifiable and non-modifiable risk factors using Prentice-weighted Cox regression and random effects meta-analysis methods. The effect of the genetic score was significantly greater in younger individuals (p for interaction  = 1.20×10-4). Relative genetic risk (per standard deviation [4.4 risk alleles]) was also larger in participants who were leaner, both in terms of body mass index (p for interaction  = 1.50×10-3) and waist circumference (p for interaction  = 7.49×10-9). Examination of absolute risks by strata showed the importance of obesity for T2D risk. The 10-y cumulative incidence of T2D rose from 0.25% to 0.89% across extreme quartiles of the genetic score in normal weight individuals, compared to 4.22% to 7.99% in obese individuals. We detected no significant interactions between the genetic score and sex, diabetes family history, physical activity, or dietary habits assessed by a Mediterranean diet score. CONCLUSIONS The relative effect of a T2D genetic risk score is greater in younger and leaner participants. However, this sub-group is at low absolute risk and would not be a logical target for preventive interventions. The high absolute risk associated with obesity at any level of genetic risk highlights the importance of universal rather than targeted approaches to lifestyle intervention.
Descripción : Journal Article; Research Support, Non-U.S. Gov't;
URI: http://hdl.handle.net/10668/1797
Versión del editor : http://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1001647
DOI: 10.1371/journal.pmed.1001647
ISSN : 1549-1676 (Online)
1549-1277 (Print)
Aparece en las colecciones: 01- Artículos - EASP. Escuela Andaluza de Salud Pública

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