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Title: Activated protein C consumption and coagulation parameters in severe sepsis and septic shock.
Authors: Torre-Prados, M de la
García-de la Torre, A
Trujillano-Fernández, C
Pérez-Vacas, J
Puerto-Morlán, A
Cámara-Sola, E
metadata.dc.contributor.authoraffiliation: [Torre-Prados,M de la; Trujillano-Fernández,C; Pérez-Vacas,J; Puerto-Morlán,A; Cámara-Sola,E] Hospital Virgen de la Victoria, Málaga, Spain. [Gracía-de la Torre,A] University Hospital Puerto Real, Cádiz, Spain.
Keywords: Choque séptico;Pruebas de coagulación sanguínea;Pronóstico;Proteina C;Tasa de supervivencia;Unidades de cuidados intensivos
metadata.dc.subject.mesh: Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Diseases::Bacterial Infections and Mycoses::Infection::Sepsis::Shock, Septic
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Hematologic Tests::Blood Coagulation Tests
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis
Medical Subject Headings::Diseases::Bacterial Infections and Mycoses::Infection::Sepsis
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Protein C
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Mortality::Survival Rate
Medical Subject Headings::Health Care::Health Care Facilities, Manpower, and Services::Health Facilities::Hospital Units::Intensive Care Units
Issue Date: Mar-2014
Publisher: BioMed Central
Citation: Torre-Prados M de la, García-de la Torre A, Trujillano-Fernández C, Pérez-Vacas J, Puerto-Morlán A, Cámara-Sola E. Activated protein C consumption and coagulation parameters in severe sepsis and septic shock. Critical Care. 2014;18(Suppl. 1):S80-S81
Abstract: Introduction Activated protein C (APC) deC ciency is prevalent in severe sepsis and septic shock patients. The aim of the study was to relate the anticoagulation activity evaluated by APC with other coagulation parameters adjusted to 28-day mortality. Methods A cohort study of 150 critically ill adults. Age, sex, sources of infection and coagulation markers within 24< hours from severe sepsis or septic shock onset, deC ned according to Surviving Sepsis Campaign (SSC) criteria, were studied. We analyzed APC activity using a hemostasis laboratory analyzer (BCS® XP; Siemens). A descriptive and comparative statistical analysis was performed using SPSS version 15.0 (SPSS Inc., Chicago, IL, USA). Results We analyzed 150 consecutive episodes of severe sepsis (16%) or septic shock (84%) admitted to the UCI. The median age of the study sample was 64 (interquartile range (IQR): 22.3<years; male: 60%). The main sources of infection were: respiratory tract 38%, intra-abdomen 45%, and 70.7% had medical pathology. The 28-day mortality was 22.7%. Nonsurvivors had a signiC cantly higher consumption of APC than survivors, 56% (IQR: 38.5) versus 68.6 (IQR: 41.4); P = 0.023. The proC le of lower levels of APC was a surgery patient with septic shock, neurological focus or catheter-related infection and Gram-negative pathogens from blood cultures. Spearman’s showed relationship with antithrombin III, r<= 0.674 (P <0.001) and International Normalized Ratio (INR), r<= –0.611 (P >0.001). See Figure 1. Conclusion Low levels of PC are associated with poor outcome and severity in severe sepsis, and it is well correlated with antithrombin III and INR.
Description: Meeting abstract
metadata.dc.identifier.doi: 10.1186/cc13416
ISSN: 1364-8535 (Print)
1466-609X (Online)
Appears in Collections:01- Artículos - Hospital de Puerto Real
01- Artículos - Hospital Virgen de la Victoria

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