Por favor, usa este identificador para citar o enlazar este ítem: http://hdl.handle.net/10668/1835
Título : Epidemiological and clinical data of hospitalizations associated with respiratory syncytial virus infection in children under 5 years of age in Spain: FIVE multicenter study.
Autor : Moreno-Perez, David
Calvo, Cristina
Filiación: [Moreno-Perez,D] Regional Universitario Hospital, Málaga, Spain. [Calvo,C] Severo Ochoa Hospital, Madrid, Spain.
Grupo de Investigación: Five Study Group
Palabras clave : Children
Hospitalization
Respiratory syncytial virus
Special populations
Preescolar
Estudios prospectivos
Infecciones por virus sincitial respiratorio
Virus sincitial respiratorio humano
Factores de Riesgo
España
MeSH: Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Patient Care::Hospitalization
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Named Groups::Persons::Age Groups::Infant
Medical Subject Headings::Check Tags::Male
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective Studies
Medical Subject Headings::Diseases::Virus Diseases::RNA Virus Infections::Mononegavirales Infections::Paramyxoviridae Infections::Pneumovirus Infections::Respiratory Syncytial Virus Infections
Medical Subject Headings::Organisms::Viruses::RNA Viruses::Mononegavirales::Paramyxoviridae::Pneumovirinae::Pneumovirus::Respiratory Syncytial Viruses::Respiratory Syncytial Virus, Human
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors
Medical Subject Headings::Geographicals::Geographic Locations::Europe::Spain
Medical Subject Headings::Named Groups::Persons::Age Groups::Child::Child, Preschool
Fecha de publicación : mar-2014
Editorial : Wiley Open Access
Cita Bibliográfica: Moreno-Perez D, Calvo C, Alfayate Miguélez S, Alvarez Alvarez C, Álvez González F, Arcos Machancoses JV, et al. Epidemiological and clinical data of hospitalizations associated with respiratory syncytial virus infection in children under 5 years of age in Spain: FIVE multicenter study. Influenza Other Respir Viruses. 2014 ; 8(2):209-16
Abstract: BACKGROUND Respiratory syncytial virus (RSV) is an important pathogen in lower respiratory tract infections (LRTI) in infants, but there are limited data concerning patients with underlying conditions and children older than 2 years of age. METHODS We have designed a prospective observational multicenter national study performed in 26 Spanish hospitals (December 2011-March 2012). Investigational cases were defined as children with underlying chronic diseases and were compared with a group of previously healthy children (proportion 1:2). Clinical data were compared between the groups. RESULTS A total of 1763 children hospitalized due to RSV infection during the inclusion period were analyzed. Of them, 225 cases and 460 healthy children were enrolled in the study. Underlying diseases observed were respiratory (64%), cardiovascular (25%), and neurologic (12%), as well as chromosomal abnormalities (7·5%), immunodeficiencies (6·7%), and inborn errors of metabolism (3·5%). Cases were statistically older than previously healthy children (average age: 16·3 versus 5·5 months). Cases experienced hypoxemia more frequently (P < 0·001), but patients with respiratory diseases required oxygen therapy more often (OR: 2·99; 95% CI: 1·03-8·65). Mechanical ventilation was used more in patients with cardiac diseases (OR: 3·0; 95% CI: 1·07-8·44) and in those with inborn errors of metabolism (OR: 12·27; 95% CI: 2·11-71·47). This subgroup showed a higher risk of admission to the PICU (OR: 6·7, 95% CI: 1·18-38·04). Diagnosis of pneumonia was more frequently found in cases (18·2% versus 9·3%; P < 0·01). CONCLUSIONS A significant percentage of children with RSV infection have underlying diseases and the illness severity is higher than in healthy children.
Descripción : Journal Article; Multicenter Study; Observational Study; Research Support, Non-U.S. Gov't;
URI: http://hdl.handle.net/10668/1835
Versión del editor : http://onlinelibrary.wiley.com/doi/10.1111/irv.12224/abstract
DOI: 10.1111/irv.12224
ISSN : 1750-2659 (Online)
1750-2640 (Print)
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