Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/1846
Título : Association of irisin with fat mass, resting energy expenditure, and daily activity in conditions of extreme body mass index.
Autor : Pardo, María
Crujeiras, Ana B
Amil, María
Agüera, Zaida
Jiménez-Murcia, Susana
Baños, Rosa
Botella, Cristina
Torre, Rafael de la
Estivill, Xavier
Fagundo, Ana B
Fernández-Real, José M
Fernández-García, José C
Fruhbeck, Gema
Gómez-Ambrosi, Javier
Rodríguez, Roser
Tinahones, Francisco J
Fernández-Aranda, Fernando
Casanueva, Felipe F
Filiación: [Pardo, M; Crujeiras, AB; Amil, M; Casanueva, FF] Laboratory of Molecular and Cellular Endocrinology, Health Research Institute of Santiago (IDIS), University Hospital of Santiago (XXIS/SERGAS), Santiago de Compostela, Spain. [Pardo, M; Crujeiras, AB; Amil, M; Agüera, Z; Jiménez-Murcia, S; Baños, R; Botella, C; Torre, R de la; Fagundo, AB; Fernández-Real, JM; Fernández-García, JC; Fruhbeck, G; Gómez-Ambrosi, J; Rodríguez, R; Tinahones, FJ; Fernández-Aranda, F; Casanueva, FF] CIBER Fisiopatología de la Obesidad y la Nutrición (CIBERobn), Santiago de Compostela, Spain. [Pardo, M] Obesidómica Group, Health Research Institute of Santiago (IDIS), University Hospital of Santiago (XXIS/SERGAS), Santiago de Compostela, Spain. [Crujeiras, AB] Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain. [Aguera, Z; Jiménez-Murcia, S; Fagundo, AB; Fernández-Aranda, F] Department of Psychiatry, University Hospital of Bellvitge-IDIBELL, Barcelona, Spain. [Jiménez-Murcia, S; Fernández-Aranda, F] Department of Clinical Sciences, School of Medicine, University of Barcelona, Spain. [Baños, R] Department of Psychological, Personality, Evaluation and Treatment, University of Valencia, Spain. [Botella, C] Department of Basic Psychology, Clinic and Psychobiology, Jaume i University, Castelló, astelló de la Plana, Spain. [Torre, R de la] Human Pharmacology and Clinical Neurosciences Research Group, Neuroscience Research Program, Hospital Del Mar Medical Research Institute (IMIM), Barcelona, Spain. [Estivill, X] Center for Genomic Regulation (CRG), Barcelona, Spain. Centro de Investigación Biomédica en Red en Epidemiologia y Salud Publica, Barcelona, Spain. [Fernández-Real, JM; Rodríguez, R] Department of Diabetes, Endocrinology and Nutrition, Institut d'Investigació Biomèdica de Girona (IdlBGi), Hospital Dr Josep Trueta, Girona, Spain. [Fernández-García, JC; Tinahones, FJ] Department of Diabetes, Endocrinology and Nutrition, Hospital Clínico Universitario Virgen de Victoria, Málaga, Spain. [Fruhbeck, G; Gómez-Ambrosi, J] Department of Endocrinology and Nutrition, University Clinic de Navarra, University of Navarra, Pamplona, Spain.
Palabras clave : Fibronectinas
Ghrelina
Índice de masa corporal
Actividad motora
Trastornos de las proteínas sanguíneas
Metabolismo energético
Anorexia nerviosa
Obesidad
MeSH: Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Globulins::Serum Globulins::Fibronectins
Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Ghrelin
Medical Subject Headings::Health Care::Environment and Public Health::Public Health::Epidemiologic Measurements::Biometry::Anthropometry::Body Mass Index
Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Motor Activity
Medical Subject Headings::Diseases::Hemic and Lymphatic Diseases::Hematologic Diseases::Blood Protein Disorders
Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Energy Metabolism
Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Psychiatry and Psychology::Mental Disorders::Eating Disorders::Anorexia Nervosa
Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity
Fecha de publicación : 22-Apr-2014
Editorial : Hindawi Publishing Corporation
Cita Bibliográfica: Pardo M, Crujeiras AB, Amil M, Agüera Z, Jiménez-Murcia S, Baños R, et al. Association of irisin with fat mass, resting energy expenditure, and daily activity in conditions of extreme body mass index. Int J Endocrinol; 2014:857270
Abstract: FNDC5/irisin has been recently postulated as beneficial in the treatment of obesity and diabetes because it is induced in muscle by exercise, increasing energy expenditure. However, recent reports have shown that WAT also secretes irisin and that circulating irisin is elevated in obese subjects. The aim of this study was to evaluate irisin levels in conditions of extreme BMI and its correlation with basal metabolism and daily activity. The study involved 145 female patients, including 96 with extreme BMIs (30 anorexic (AN) and 66 obese (OB)) and 49 healthy normal weight (NW). The plasma irisin levels were significantly elevated in the OB patients compared with the AN and NW patients. Irisin also correlated positively with body weight, BMI, and fat mass. The OB patients exhibited the highest REE and higher daily physical activity compared with the AN patients but lower activity compared with the NW patients. The irisin levels were inversely correlated with daily physical activity and directly correlated with REE. Fat mass contributed to most of the variability of the irisin plasma levels independently of the other studied parameters. Conclusion. Irisin levels are influenced by energy expenditure independently of daily physical activity but fat mass is the main contributing factor.
Descripción : Journal Article;
URI: http://hdl.handle.net/10668/1846
Versión del editor : http://www.hindawi.com/journals/ije/2014/857270/abs/
DOI: 10.1155/2014/857270
ISSN : 1687-8345 (Online)
1687-8337 (Print)
Appears in Collections:01- Artículos - Hospital Virgen de la Victoria

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