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Título : Tumor microenvironment and immune effects of antineoplastic therapy in lymphoproliferative syndromes.
Autor : Alvaro, Tomás
Cruz-Merino, Luis de la
Henao-Carrasco, Fernando
Villar Rodríguez, José Luis
Vicente Baz, David
Codes Manuel de Villena, Manuel
Provencio, Mariano
Filiación: [Álvaro,T] Pathology Department, Hospital de Tortosa, Verge de la Cinta, Tortosa, Spain. [Cruz-Merino,L de la; Henao-Carrasco,F; Vicente Baz,D; Codes Manuel de Villena,M] Clinical Oncology Department, Hospital Universitario Virgen Macarena, Sevilla, Spain. [Villar Rodríguez,JL] Pathology Department, Hospital Universitario Virgen Macarena, Sevilla, Spain. [Provencio,M] Clinical Oncology Department, Hospital Universitario Puerta de Hierro, Madrid, Spain.
Palabras clave : Antineoplásicos;Humanos;Trastornos linfoproliferativos;Microambiente tumoral;Animales
MeSH: Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic Agents
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Diseases::Hemic and Lymphatic Diseases::Lymphatic Diseases::Lymphoproliferative Disorders
Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cellular Microenvironment::Tumor Microenvironment
Medical Subject Headings::Organisms::Eukaryota::Animals
Fecha de publicación : 2010
Editorial : Hindawi Publishing Corporation
Cita Bibliográfica: Álvaro T, Cruz-Merino L de la , Henao-Carrasco F, Villar Rodríguez JL, Vicente Baz D, Codes Manuel de Villena M, Provencio M. Tumor microenvironment and immune effects of antineoplastic therapy in lymphoproliferative syndromes. J Biomed Biotechnol. 2010; pii: 846872
Abstract: Lymphomas represent a wide group of heterogenic diseases with different biological and clinical behavior. The underlying microenvironment-specific composition seems to play an essential role in this scenario, harboring the ability to develop successful immune responses or, on the contrary, leading to immune evasion and even promotion of tumor growth. Depending on surrounding lymphoid infiltrates, lymphomas may have different prognosis. Moreover, recent evidences have emerged that confer a significant impact of main lymphoma's treatment over microenvironment, with clinical consequences. In this review, we summarize these concepts from a pathological and clinical perspective. Also, the state of the art of lymphoma's anti-idiotype vaccine development is revised, highlighting the situations where this strategy has proven to be successful and eventual clues to obtain better results in the future.
Descripción : Journal Article; Review;
URI: http://hdl.handle.net/10668/1900
Versión del editor : http://www.hindawi.com/journals/bmri/2010/846872/abs/
DOI: 10.1155/2010/846872
ISSN : 1110-7251 (Online)
1110-7243 (Print)
Aparece en las colecciones: 01- Artículos - Hospital Virgen Macarena

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