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Título : Breast cancer prognostic classification in the molecular era: the role of histological grade.
Autor : Rakha, Emad A.
Reis-Filho, Jorge S.
Baehner, Frederick
Dabbs, David J.
Decker, Thomas
Eusebi, Vincenzo
Fox, Stephen B.
Ichihara, Shu
Jacquemier, Jocelyne
Lakhani, Sunil R.
Palacios, José
Richardson, Andrea L.
Schnitt, Stuart J.
Schmitt, Fernando C.
Tan, Puay-Hoon
Tse, Gary M.
Badve, Sunil
Ellis, Ian O.
Filiación: [Rakha,EA; Ellis,IO] Department of Histopathology, Nottingham University Hospital NHS Trust, Nottingham, UK. [Reis-Filho,JS] The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK. [Baehner,F] Department of Anatomic Pathology, University of California, San Francisco, CA, USA. [Dabbs,DJ] University of Pittsburgh Medical Center, Pittsburgh, PA, USA. [Decker,T] Breast-Screening-Pathology, Reference Centre Munster, Gerhard Domagk-Institute of Pathology, University Hospital Münster, Münster, Germany. [Eusebi,V] Sezione Anatomia Istologia e Citologia Patologica 'M. Malpighi', Università-ASL Ospedale Bellaria, Bologna, Italia. [Fox,SF] Pathology Department, Peter MacCallum Cancer Centre, East Melbourne, Victoria , Australia. [Ichihara,S] Department of Pathology, Nagoya Medical Center, Naka-ku, Nagoya Japan. [Jacquemier,J] Unité d'Anatomie et de Cytologie Pathologiques, Institut Paoli-Calmettes, Marseille, France. [Lakhani,SR] Molecular and Cellular Pathology, The University of Queensland, Mayne Medical School, Brisbane, Australia. [Palacios,J] Servicio de Anatomía Patológica, Hospital Universitario Virgen del Rocio, Sevilla, Spain. [Richardson,AL] Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, USA. [Schnitt,SJ] Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA. [Schmitt,FC] Institute of Molecular Pathology and Immunology (IPATIMUP) and Medical Faculty, University of Porto, Porto, Portugal. [Tan,P-H] Department of Pathology, Singapore General Hospital, Singapore. [Tse,GM] Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, Shatin, Hong Kong. [Badve,S] Departments of Pathology and Internal Medicine, Clarian Pathology Lab of Indiana University, Indianapolis, USA.
Palabras clave : Femenino
Perfilación de la expresión génica
Regulación neoplásica de la expresión génica
Ganglios linfáticos
MeSH: Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Gene Expression Profiling
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Gene Expression Regulation, Neoplastic
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Anatomy::Tissues::Lymphoid Tissue::Lymph Nodes
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Health Surveys::Health Status Indicators::Severity of Illness Index
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Anthropometry::Body Weights and Measures::Tumor Burden
Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Breast Neoplasms
Fecha de publicación : 30-Jul-2010
Cita Bibliográfica: Rakha EA, Reis-Filho JS, Baehner F, Dabbs DJ, Decker T, Eusebi V, et al. Breast cancer prognostic classification in the molecular era: the role of histological grade. Breast Cancer Res. 2010; 12(4):207
Abstract: Breast cancer is a heterogeneous disease with varied morphological appearances, molecular features, behavior, and response to therapy. Current routine clinical management of breast cancer relies on the availability of robust clinical and pathological prognostic and predictive factors to support clinical and patient decision making in which potentially suitable treatment options are increasingly available. One of the best-established prognostic factors in breast cancer is histological grade, which represents the morphological assessment of tumor biological characteristics and has been shown to be able to generate important information related to the clinical behavior of breast cancers. Genome-wide microarray-based expression profiling studies have unraveled several characteristics of breast cancer biology and have provided further evidence that the biological features captured by histological grade are important in determining tumor behavior. Also, expression profiling studies have generated clinically useful data that have significantly improved our understanding of the biology of breast cancer, and these studies are undergoing evaluation as improved prognostic and predictive tools in clinical practice. Clinical acceptance of these molecular assays will require them to be more than expensive surrogates of established traditional factors such as histological grade. It is essential that they provide additional prognostic or predictive information above and beyond that offered by current parameters. Here, we present an analysis of the validity of histological grade as a prognostic factor and a consensus view on the significance of histological grade and its role in breast cancer classification and staging systems in this era of emerging clinical use of molecular classifiers.
Descripción : Journal Article; Review;
Versión del editor :
DOI: 10.1186/bcr2607
ISSN : 1465-542X (Online)
1465-5411 (Print)
Appears in Collections:01- Artículos - Hospital Virgen del Rocío

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