Por favor, usa este identificador para citar o enlazar este ítem: http://hdl.handle.net/10668/1964
Título : Frequency and characteristics of familial melanoma in Spain: the FAM-GEM-1 Study.
Autor : Márquez-Rodas, Iván
Martín González, Manuel
Nagore, Eduardo
Gómez-Fernández, Cristina
Avilés-Izquierdo, Jose Antonio
Maldonado-Seral, Cayetana
Soriano, Virtudes
Majem-Tarruella, Margarita
Palomar, Virginia
Maseda, Rocio
Martín-Carnicero, Alfonso
Puertolas, Teresa
Godoy, Elena
Cerezuela, Pablo
Ochoa de Olza, Maria
Campos, Begoña
Perez-Ruiz, Elisabeth
Soria, Ainara
Gil-Arnaiz, Irene
Gonzalez-Cao, Maria
Galvez, Elisa
Arance, Ana
Belon, Joaquin
Cruz-Merino, Luis de la
Martín-Algarra, Salvador
Filiación: [Márquez-Rodas,I] Servicio de Oncología Médica, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain. [Martín González,M] Servicio de Dermatología, Hospital Ramón y Cajal, Madrid, Spain. [Nagore,E] Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, Spain. [Gómez-Fernández,C; Maseda,R] Servicio de Dermatología, Hospital La Paz, Madrid, Spain. [Avilés-Izquierdo,JA] Servicio de Dermatología, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain. [Maldonado-Seral,C] Servicio de Dermatología, Hospital Universitario Central de Asturias, Oviedo, Spain. [Soriano,V] Servicio de Oncología Médica, Instituto Valenciano de Oncología, Valencia, Spain. [Majem-Tarruella,M] Servicio de Oncología Médica, Hospital de Sant Pau, Barcelona, Spain. [Maseda,R]Servicio de Oncología Médica, Hospital de San Pedro, Logroño, Spain. [Puertolas,T] Servicio de Oncología, Hospital Universitario Miguel Servet, Zaragoza, Spain. [Godoy,E] Servicio de Dermatología, Hospital de Cabueñes, Gijon, Spain. [Cerezuela,P] Servicio de Oncología Médica, Hospital General Universitario Santa Lucia, Cartagena, Spain. [Ochoa de Olza,M] Servicio de Oncología Médica, Instituto Catalan de Oncología, Hospitalet, Spain. [Campos,B] Servicio de Oncología Médica, Hospital Lucus Augusti, Lugo, Spain. [Pérez-Ruiz,E] Servicio de Oncología Médica, Hospital Costa del Sol, Marbella, Spain. [Soria,A] Servicio de Oncología Médica, Hospital Ramón y Cajal, Madrid, Spain. [Gil-Arnaiz,I] Servicio de Oncología Medica, Hospital Reina Sofía, Tudela, Spain. [Gonzalez-Cao,M] Servico de Oncología Médica, Instituto Dexeus, Barcelona, Spain. [Galvez,E] Servicio de Oncología Médica, Hospital de Elda, Alicante, Spain. [Arance,A] Servicio de Oncología Medica, Hospital Clinic, Barcelona, Spain. [Belon,J] Servicio de Oncología Médica, Clínica Oncogranada, Granada, Spain. [Cruz-Merino,L de la] Servicio de Oncología Médica, Hospital Virgen de la Macarena, Sevilla, Spain. [Martín-Algarra,S] Departamento de Oncología, Clínica Universidad de Navarra, Pamplona, Spain.
Grupo de Investigación: Spanish Multidisciplinary Group of Melanoma (GEM).
Palabras clave : Melanoma
Risk factor
Family history
Multiple melanoma
Amilial melanoma patients
Dermatología
Mitosis
Neoplasias Pancreáticas
Pronóstico
Factores de Riesgo
Quemadura Solar
MeSH: Medical Subject Headings::Disciplines and Occupations::Health Occupations::Medicine::Dermatology
Medical Subject Headings::Named Groups::Persons::Population Groups::Ethnic Groups::Hispanic Americans
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Germ Cell and Embryonal::Neuroectodermal Tumors::Neuroendocrine Tumors::Melanoma
Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Cycle::Cell Division::Cell Nucleus Division::Mitosis
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Analysis of Variance::Multivariate Analysis
Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Pancreatic Neoplasms
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors
Medical Subject Headings::Geographicals::Geographic Locations::Europe::Spain
Medical Subject Headings::Diseases::Skin and Connective Tissue Diseases::Skin Diseases::Photosensitivity Disorders::Sunburn
Fecha de publicación : 13-abr-2015
Editorial : Public Library of Science
Cita Bibliográfica: Márquez-Rodas I, Martín González M, Nagore E, Gómez-Fernández C, Avilés-Izquierdo JA, Maldonado-Seral C, et al. Frequency and characteristics of familial melanoma in Spain: the FAM-GEM-1 Study. PLoS ONE. 2015; 10(4):e0124239
Abstract: INTRODUCTION Familial history of melanoma is a well-known risk factor for the disease, and 7% melanoma patients were reported to have a family history of melanoma. Data relating to the frequency and clinical and pathological characteristics of both familial and non-familial melanoma in Spain have been published, but these only include patients from specific areas of Spain and do not represent the data for the whole of Spain. PATIENTS AND METHODS An observational study conducted by the Spanish Group of Melanoma (GEM) analyzed the family history of patients diagnosed with melanoma between 2011 and 2013 in the dermatology and oncology departments. RESULTS In all, 1047 patients were analyzed, and 69 (6.6%) fulfilled criteria for classical familial melanoma (two or more first-degree relatives diagnosed with melanoma). Taking into account other risk factors for familial melanoma, such as multiple melanoma, pancreatic cancer in the family or second-degree relatives with melanoma, the number of patients fulfilling the criteria increased to 165 (15.8%). Using a univariate analysis, we determined that a Breslow index of less than 1 mm, negative mitosis, multiple melanoma, and a history of sunburns in childhood were more frequent in familial melanoma patients, but a multivariate analysis revealed no differences in any pathological or clinical factor between the two groups. CONCLUSIONS Similar to that observed in other countries, familial melanoma accounts for 6.6% of melanoma diagnoses in Spain. Although no differences in the multivariate analysis were found, some better prognosis factors, such as Breslow index, seem more frequent in familial melanoma, which reflect a better early detection marker and/or a different biological behavior.
Descripción : Journal Article;
URI: http://hdl.handle.net/10668/1964
Versión del editor : http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0124239
DOI: 10.1371/journal.pone.0124239
ISSN : 1932-6203 (Online)
Aparece en las colecciones: 01- Artículos - APES Costa del Sol
01- Artículos - Hospital Virgen Macarena

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