Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/1981
Título : The administration of atomoxetine during alcohol deprivation induces a time-limited increase in alcohol consumption after relapse.
Autor : Alén, Francisco
Serrano, Antonia
Gorriti, Miguel Ángel
Pavón, Francisco Javier
Orio, Laura
Gómez de Heras, Raquel
Ramírez-López, María Teresa
Antón, María
Pozo, Miguel Ángel
Rodríguez de Fonseca, Fernando
Filiación: [Alén,F; Gorriti,MA; Gómez de Heras,R; Ramírez-López,MT; Rodríguez de Fonseca,F] Departamento de Psicobiología, Facultad de Psicología, Universidad Complutense de Madrid, Spain. [Alén,F; Serrano,A; Pavón,FJ; Orio,L; Antón,M; Rodríguez de Fonseca,F] Instituto IBIMA, Unidad de Gestión Clínica de Salud Mental, Hospital Regional Universitario de Málaga, Universidad de Málaga, Spain. [Pozo,MA] Instituto Pluridisciplinar, Universidad Complutense de Madrid, Spain.
Palabras clave : Alcoholism
Atomoxetine
Rat
Relapse
Antidepressants
Consumo de alcohol
Depresores del sistema nervioso central
Modelos de enfermedad en animales
Etanol
Inhibidores de la captación adrenérgica
MeSH: Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Drinking Behavior::Alcohol Drinking
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Analysis of Variance
Medical Subject Headings::Organisms::Eukaryota::Animals
Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Central Nervous System Depressants
Medical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Learning::Conditioning (Psychology)::Conditioning, Operant
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models, Animal::Disease Models, Animal
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Alcohols::Ethanol
Medical Subject Headings::Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Musculoskeletal Physiological Processes::Movement::Locomotion
Medical Subject Headings::Check Tags::Male
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amines::Propylamines
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats::Rats, Wistar
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Recurrence
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Self Administration
Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Neurotransmitter Agents::Adrenergic Agents::Adrenergic Uptake Inhibitors
Fecha de publicación : Nov-2014
Editorial : Oxford University Press
Cita Bibliográfica: Alén F, Serrano A, Gorriti MÁ, Pavón FJ, Orio L, de Heras RG, et al. The administration of atomoxetine during alcohol deprivation induces a time-limited increase in alcohol consumption after relapse. Int. J. Neuropsychopharmacol. 2014; 17(11):1905-10
Abstract: The administration of selective serotonin reuptake inhibitors (SSRIs) typically used as antidepressants increases alcohol consumption after an alcohol deprivation period in rats. However, the appearance of this effect after the treatment with selective noradrenaline reuptake inhibitors (SNRIs) has not been studied. In the present work we examined the effects of a 15-d treatment with the SNRI atomoxetine (1, 3 and 10 mg/kg, i.p.) in male rats trained to drink alcohol solutions in a 4-bottle choice test. The treatment with atomoxetine (10 mg/kg, i.p.) during an alcohol deprivation period increased alcohol consumption after relapse. This effect only lasted one week, disappearing thereafter. Treatment with atomoxetine did not cause a behavioral sensitized response to a challenge dose of amphetamine (1.5 mg/kg, i.p.), indicating the absence of a supersensitive dopaminergic transmission. This effect is markedly different from that of SSRI antidepressants that produced both long-lasting increases in alcohol consumption and behavioral sensitization. Clinical implications are discussed.
Descripción : Journal Article; Research Support, Non-U.S. Gov't;
URI: http://hdl.handle.net/10668/1981
Versión del editor : http://ijnp.oxfordjournals.org/content/17/11/1905.long
DOI: 10.1017/S146114571400087X
ISSN : 1469-5111 (Online)
1461-1457 (Print)
Appears in Collections:01- Artículos - IBIMA. Instituto de Investigación Biomédica de Málaga
01- Artículos - Hospital Regional de Málaga

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