Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/1987
Título : No evidence of association between common autoimmunity STAT4 and IL23R risk polymorphisms and non-anterior uveitis.
Autor : Cénit, María Carmen
Márquez, Ana
Cordero-Coma, Miguel
Gorroño-Echebarría, Marina Begoña
Fonollosa, Alejandro
Adán, Alfredo
Martínez-Berriotxoa, Agustín
Díaz Valle, David
Pato, Esperanza
Blanco, Ricardo
Cañal, Joaquín
Díaz-Llopis, Manuel
García Serrano, José Luis
de Ramón, Enrique
Del Rio, María José
Martín-Villa, José Manuel
Molins, Blanca
Ortego-Centeno, Norberto
Martín, Javier
Filiación: [Cénti,MC; Márquez,A; Martín,J] Instituto de Parasitología y Biomedicina López-Neyra, IPBLN, CSIC, Granada, Spain. [Cordero-Coma,M] Ophthalmology Department, Hospital de León, León, Spain. [Gorroño-Echebarría, MB] Ophthalmology Department, Hospital Universitario Principe de Asturias, Alcalá de Henares, Spain. [Fonollosa,A; Martínez-Berriotxoa,A] Internal Medicine Department, Hospital de Cruces, Bilbao, Spain. [Adán,A; Molins,B] Ophthalmology Department, Hospital Clinic, Barcelona, Spain. [DÍaz Valle,D] Ophthalmology Department, Hospital Clínico San Carlos, Madrid, Spain. [Pato,E] Rheumatology Department, Hospital Clínico San Carlos, Madrid, Spain. [Blanco,R] Rheumatology Department, Hospital Marqués de Valdecilla, IFIMAV, Santander, Spain. [Cañal,J] Ophthalmology Department, Hospital Marqués de Valdecilla, Santander, Spain. [Díaz-Llopis,M] Ophthalmology Department, Hospital Universitario La Fe, Valencia, Spain. [García Serrano,JL] Ophthalmology Department, Hospital Clínico San Cecilio, Granada, Spain. [Ramón de, E] Internal Medicine Department, Hospital Carlos Haya, Málaga, Spain. [Río del,MJ] Ophthalmology Department, Hospital Carlos Haya, Málaga, Spain. [Martín-Villa,JM] Immunology Department, Facultad de Medicina, Universidad Complutense de Madrid, Spain. [Ortego-Centeno,N] Internal Medicine Department, Hospital Clínico San Cecilio, Granada, Spain.
Palabras clave : Receptors, Interleukin
STAT4 Transcription Factor
IL23R protein, human
Alelos
Autoinmunidad
Genotipo
Polimorfismo genético
Polimorfismo de nucleótido simple
Receptores de interleucina
Factores de transcripción
Uveítis
MeSH: Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Alleles
Medical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immunity::Autoimmunity
Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Check Tags::Male
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic::Polymorphism, Single Nucleotide
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, Immunologic::Receptors, Cytokine::Receptors, Interleukin
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intracellular Signaling Peptides and Proteins::Adaptor Proteins, Signal Transducing::STAT Transcription Factors
Medical Subject Headings::Diseases::Eye Diseases::Uveal Diseases::Uveitis
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult
Fecha de publicación : 2013
Editorial : Public Library of Science
Cita Bibliográfica: Cénit MC, Márquez A, Cordero-Coma M, Gorroño-Echebarría MB, Fonollosa A, Adán A, et al. No evidence of association between common autoimmunity STAT4 and IL23R risk polymorphisms and non-anterior uveitis. PLoS ONE. 2013, 8(11):e72892
Abstract: OBJECTIVE: STAT4 and IL23R loci represent common susceptibility genetic factors in autoimmunity. We decided to investigate for the first time the possible role of different STAT4/IL23R autoimmune disease-associated polymorphisms on the susceptibility to develop non-anterior uveitis and its main clinical phenotypes. METHODS Four functional polymorphisms (rs3821236, rs7574865, rs7574070, and rs897200) located within STAT4 gene as well as three independent polymorphisms (rs7517847, rs11209026, and rs1495965) located within IL23R were genotyped using TaqMan® allelic discrimination in a total of 206 patients with non-anterior uveitis and 1553 healthy controls from Spain. RESULTS No statistically significant differences were found when allele and genotype distributions were compared between non-anterior uveitis patients and controls for any STAT4 (rs3821236: P=0.39, OR=1.12, CI 95%=0.87-1.43; rs7574865: P=0.59 OR=1.07, CI 95%=0.84-1.37; rs7574070: P=0.26, OR=0.89, CI 95%=0.72-1.10; rs897200: P=0.22, OR=0.88, CI 95%=0.71-1.08;) or IL23R polymorphisms (rs7517847: P=0.49, OR=1.08, CI 95%=0.87-1.33; rs11209026: P=0.26, OR=0.78, CI 95%=0.51-1.21; rs1495965: P=0.51, OR=0.93, CI 95%=0.76-1.15). CONCLUSION Our results do not support a relevant role, similar to that described for other autoimmune diseases, of IL23R and STAT4 polymorphisms in the non-anterior uveitis genetic predisposition. Further studies are needed to discard a possible weak effect of the studied variant.
Descripción : Journal Article;
URI: http://hdl.handle.net/10668/1987
Versión del editor : http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0072892
DOI: 10.1371/journal.pone.0072892
ISSN : 1932-6203 (Online)
Appears in Collections:01- Artículos - Hospital Regional de Málaga
01- Artículos - Hospital San Cecilio

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