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http://hdl.handle.net/10668/1990
Title: | Serum sCD163 levels are associated with type 2 diabetes mellitus and are influenced by coffee and wine consumption: results of the Di@bet.es study. |
Authors: | Rojo-Martínez, Gemma Maymó-Masip, Elsa Rodríguez, M Mar Solano, Esther Goday, Albert Soriguer, Federico Valdés, Sergio Chaves, Felipe Javier Delgado, Elías Colomo, Natalia Hernández, Pilar Vendrell, Joan Chacón, Matilde R |
metadata.dc.contributor.authoraffiliation: | [Rojo-Martínez,G; Soriguer,F; Valdés,S; Colomo,N] UGCI de Endocrinología y Nutrición, Instituto de Biomedicina de Málaga (IBIMA), Hospital Regional Universitario, Málaga, Spain. [Rojo-Martínez,G; Maymó-Masip,E; Solano,E; Soriguer,F; Valdés,S; Chaves,FJ; Colomo,N; Vendrell,J; Chacón,MR] Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas CIBERDEM, Barcelona, Spain. Maymó-Masip,E; Solano,E; Hernández,P; Vendrel,J; Chacón,MR] Hospital Universitari de Tarragona Joan XXIII, IISPV, Universitat Rovira i Virgili, Tarragona, Spain. [Rodríguez,MM] CIBERObn Fisiopatología, Obesidad y Nutrición, Institut D’investigacio Biomedica De Girona Dr Josep Trueta, Girona, Spain. [Goday,A] Department of Endocrinology and Nutrition Hospital del Mar, Parc de Salut Mar, Universitat Autónoma de Barcelona, Barcelona, Spain. [Chaves,FJ] Genotyping and Genetic Diagnosis Unit, Fundación de Investigación del Hospital Clínico de Valencia-INCLIVA, Valencia, Spain. [Delgado,E] Departamento de Medicina-Endocrinología y Nutrición, Hospital Universitario Central de Asturias (HUCA), Universidad de Oviedo, Oviedo, Spain. |
Keywords: | Café;Diabetes mellitus tipo II;Conducta bebedora;Hábitos alimenticios;Funciones de verosimilitud;Solubilidad;Vino;España |
metadata.dc.subject.mesh: | Medical Subject Headings::Chemicals and Drugs::Biological Factors::Biological Markers::Antigens, Differentiation::Antigens, Differentiation, Myelomonocytic Medical Subject Headings::Chemicals and Drugs::Complex Mixtures::Biological Agents::Plant Preparations::Coffee Medical Subject Headings::Diseases::Endocrine System Diseases::Diabetes Mellitus::Diabetes Mellitus, Type 2 Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Drinking Behavior Medical Subject Headings::Check Tags::Female Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Feeding Behavior::Food Habits Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Likelihood Functions Medical Subject Headings::Check Tags::Male Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged Receptors, Cell Surface Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Physicochemical Phenomena::Solubility Medical Subject Headings::Geographicals::Geographic Locations::Europe::Spain Medical Subject Headings::Chemicals and Drugs::Biological Factors::Intercellular Signaling Peptides and Proteins::Tumor Necrosis Factors Medical Subject Headings::Technology, Industry, Agriculture::Food and Beverages::Beverages::Alcoholic Beverages::Wine Medical Subject Headings::Chemicals and Drugs::Biological Factors::Biological Markers::Antigens, Differentiation::Antigens, CD |
Issue Date: | 30-Jun-2014 |
Publisher: | Public Library of Science |
Citation: | Rojo-Martínez G, Maymó-Masip E, Rodríguez MM, Solano E, Goday A, Soriguer F, et al. Serum sCD163 levels are associated with type 2 diabetes mellitus and are influenced by coffee and wine consumption: results of the Di@bet.es study. PLoS ONE. 2014; 9(6):e101250 |
Abstract: | OBJECTIVE Serum levels of soluble TNF-like weak inducer of apoptosis (sTWEAK) and its scavenger receptor CD163 (sCD163) have been linked to insulin resistance. We analysed the usefulness of these cytokines as biomarkers of type 2 diabetes in a Spanish cohort, together with their relationship to food consumption in the setting of the Di@bet.es study. RESEARCH DESIGN AND METHODS This is a cross-sectional, matched case-control study of 514 type 2 diabetes subjects and 517 controls with a Normal Oral Glucose Tolerance Test (NOGTT), using data from the Di@bet.es study. Study variables included clinical and demographic structured survey, food frequency questionnaire and physical examination. Serum concentrations of sTWEAK and sCD163 were measured by ELISA. Linear regression analysis determined which variables were related to sTWEAK and sCD163 levels. Logistic regression analysis was used to estimate odd ratios of presenting type 2 diabetes. RESULTS sCD163 concentrations and sCD163/sTWEAK ratio were 11.0% and 15.0% higher, respectively, (P<0.001) in type 2 diabetes than in controls. Following adjustment for various confounders, the OR for presenting type 2 diabetes in subjects in the highest vs the lowest tertile of sCD163 was [(OR), 2,01 (95%CI, 1,46-2,97); P for trend <0.001]. Coffee and red wine consumption was negatively associated with serum levels of sCD163 (P = 0.0001 and; P = 0.002 for coffee and red wine intake, respectively). CONCLUSIONS High circulating levels of sCD163 are associated with type 2 diabetes in the Spanish population. The association between coffee and red wine intake and these biomarkers deserves further study to confirm its potential role in type 2 diabetes. |
Description: | Journal Article; Research Support, Non-U.S. Gov't; |
URI: | http://hdl.handle.net/10668/1990 |
metadata.dc.relation.publisherversion: | http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0101250 |
metadata.dc.identifier.doi: | 10.1371/journal.pone.0101250 |
ISSN: | 1932-6203 (Online) |
Appears in Collections: | 01- Artículos - Hospital Regional de Málaga 01- Artículos - IBIMA. Instituto de Investigación Biomédica de Málaga |
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RojoMartinez_SerumsCD163.pdf | Artículo publicado | 222 kB | Adobe PDF | View/Open |
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