Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorEspinosa-Sanchez, Juan M-
dc.contributor.authorLopez-Escamez, Jose A-
dc.identifier.citationEspinosa-Sanchez JM, Lopez-Escamez JA. New insights into pathophysiology of vestibular migraine. Front Neurol. 2015 6:12es
dc.identifier.issn1664-2295 (Online)-
dc.descriptionJournal Article; Review;es
dc.description.abstractVestibular migraine (VM) is a common disorder in which genetic, epigenetic, and environmental factors probably contribute to its development. The pathophysiology of VM is unknown; nevertheless in the last few years, several studies are contributing to understand the neurophysiological pathways involved in VM. The current hypotheses are mostly based on the knowledge of migraine itself. The evidence of trigeminal innervation of the labyrinth vessels and the localization of vasoactive neuropeptides in the perivascular afferent terminals of these trigeminal fibers support the involvement of the trigemino-vascular system. The neurogenic inflammation triggered by activation of the trigeminal-vestibulocochlear reflex, with the subsequent inner ear plasma protein extravasation and the release of inflammatory mediators, can contribute to a sustained activation and sensitization of the trigeminal primary afferent neurons explaining VM symptoms. The reciprocal connections between brainstem vestibular nuclei and the structures that modulate trigeminal nociceptive inputs (rostral ventromedial medulla, ventrolateral periaqueductal gray, locus coeruleus, and nucleus raphe magnus) are critical to understand the pathophysiology of VM. Although cortical spreading depression can affect cortical areas involved in processing vestibular information, functional neuroimaging techniques suggest a dysmodulation in the multimodal sensory integration and processing of vestibular and nociceptive information, resulting from a vestibulo-thalamo-cortical dysfunction, as the pathogenic mechanism underlying VM. The elevated prevalence of VM suggests that multiple functional variants may confer a genetic susceptibility leading to a dysregulation of excitatory-inhibitory balance in brain structures involved in the processing of sensory information, vestibular inputs, and pain. The interactions among several functional and structural neural networks could explain the pathogenic mechanisms of
dc.publisherFrontiers Research Foundationes
dc.relation.ispartofFrontiers in Neurologyes
dc.subjectVestibular systemes
dc.subjectMigraña con Auraes
dc.subjectEnfermedades del Nervio Vestibulococleares
dc.subjectMultisensory integrationes
dc.subjectVestibulo-thalamo-cortical systemes
dc.subjectEnfermedad de Menierees
dc.subjectMeniere’s diseasees
dc.subjectNervio Vestibulares
dc.subject.meshMedical Subject Headings::Diseases::Otorhinolaryngologic Diseases::Ear Diseases::Labyrinth Diseases::Endolymphatic Hydrops::Meniere Diseasees
dc.subject.meshMedical Subject Headings::Diseases::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Headache Disorders::Headache Disorders, Primary::Migraine Disorders::Migraine with Auraes
dc.subject.meshMedical Subject Headings::Diseases::Otorhinolaryngologic Diseases::Ear Diseases::Labyrinth Diseases::Vestibular Diseases::Vertigoes
dc.subject.meshMedical Subject Headings::Anatomy::Nervous System::Peripheral Nervous System::Peripheral Nerves::Cranial Nerves::Vestibulocochlear Nerve::Vestibular Nervees
dc.subject.meshMedical Subject Headings::Diseases::Otorhinolaryngologic Diseases::Ear Diseases::Retrocochlear Diseases::Vestibulocochlear Nerve Diseaseses
dc.titleNew insights into pathophysiology of vestibular
dc.rights.accessRightsAcceso abiertoes
dc.contributor.authoraffiliation[Espinosa-Sanchez,JM; Lopez-Escamez,JA] Otology and Neurotology Group CTS495, Human DNA Variability Department, GENYO Centre for Genomics and Oncological Research Pfizer - University of Granada - Junta de Andalucia, Granada, España. [Espinosa-Sanchez,JM] Department of Otolaryngology, Hospital San Agustin, Linares, Spain [Lopez-Escamez,JA] Department of Otolaryngology, Hospital de Poniente, El Ejido, Spaines
Appears in Collections:01- Artículos - AGS Norte de Jaén
01- Artículos - APES Hospital de Poniente

Files in This Item:
File Description SizeFormat 
Espinosa_New.pdfArticulo publicado548,86 kBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons