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Title: Colorectal Cancer Classification and Cell Heterogeneity: A Systems Oncology Approach.
Authors: Blanco-Calvo, Moisés
Concha, Ángel
Figueroa, Angélica
Garrido, Federico
Valladares-Ayerbes, Manuel
metadata.dc.contributor.authoraffiliation: [Blanco-Calvo.M;Concha,A;Figueroa,A; Valladares-Ayerbes,M ] Translational Cancer Research Group, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Complexo Hospitalario Universitario de A Coruña (CHUAC), Servizo Galego de Saúde (SERGAS), Universidade da Coruña (UDC) A Coruña, Spain. [Concha,A] Pathology Department, Complexo Hospitalario Universitario A Coruña (CHUAC), Servizo Galego de Saúde (SERGAS),A Coruña, Spain. [Garrido,F] Departamento de Bioquímica, Biología Molecular III e Inmunología, Facultad de Medicina, Universidad de Granada, Granada, Spain. UGC de Laboratorio Clínico, Hospital Universitario Virgen de las Nieves, Servicio de Análisis Clínicos, Granada, Spain. Instituto de Investigacion Biosanitaria de Granada (IBISGranada), Granada, Spain. [Valladares-Ayerbes,M] Medical Oncology Department, Complexo Hospitalario Universitario A Coruña (CHUAC), Servizo Galego de Saúde (SERGAS), A Coruña, Spain.
Keywords: Colorectal cancer;Classification;Heterogeneity;Cancer systems biology;Molecular pathology;Targeted therapy;Precision medicine;Neoplasias Colorrectales;Medicina Individualizada;Terapia Molecular Dirigida;Humanos;Biología de Sistemas
metadata.dc.subject.mesh: Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Individualized Medicine
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Molecular Targeted Therapy
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Computational Biology::Systems Biology
Issue Date: 15-Jun-2015
Publisher: MDPI
Citation: Blanco-Calvo M, Concha Á, Figueroa A, Garrido F, Valladares-Ayerbes M. Colorectal Cancer Classification and Cell Heterogeneity: A Systems Oncology Approach. Int J Mol Sci. 2015; 16(6):13610-13632
Abstract: Colorectal cancer is a heterogeneous disease that manifests through diverse clinical scenarios. During many years, our knowledge about the variability of colorectal tumors was limited to the histopathological analysis from which generic classifications associated with different clinical expectations are derived. However, currently we are beginning to understand that under the intense pathological and clinical variability of these tumors there underlies strong genetic and biological heterogeneity. Thus, with the increasing available information of inter-tumor and intra-tumor heterogeneity, the classical pathological approach is being displaced in favor of novel molecular classifications. In the present article, we summarize the most relevant proposals of molecular classifications obtained from the analysis of colorectal tumors using powerful high throughput techniques and devices. We also discuss the role that cancer systems biology may play in the integration and interpretation of the high amount of data generated and the challenges to be addressed in the future development of precision oncology. In addition, we review the current state of implementation of these novel tools in the pathological laboratory and in clinical practice.
Description: REVIEW;
metadata.dc.identifier.doi: 10.3390/ijms160613610
ISSN: 1422-0067 (Online)
Appears in Collections:01- Artículos - Hospital Virgen de las Nieves
01- Artículos - ibsGRANADA. Instituto de Investigación Biosanitaria de Granada

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