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Title: Role of immune escape mechanisms in Hodgkin's lymphoma development and progression: a whole new world with therapeutic implications.
Authors: Lejeune, Marylène
Nogales Fernández, Esteban
Henao Carrasco, Fernando
Grueso López, Ana
Illescas Vacas, Ana
Pulla, Mariano Provencio
Callau, Cristina
Álvaro, Tomás
metadata.dc.contributor.authoraffiliation: [de la Cruz-Merino,L; Nogales Fernández,E; Henao Carrasco,F; Grueso López,A] Clinical Oncology Department, Hospital Universitario Virgen Macarena, Sevilla, Spain. [Lejeune,M; Callau,C] Molecular Biology and Research Section, Hospital de Tortosa Verge de la Cinta and IISPV, URV, Reus, Spain. [Illescas Vacas,A] Radiotherapy Department, Hospital Universitario Virgen Macarena, Sevilla, Spain.[Pulla,MP] Clinical Oncology Department, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain. [Álvaro,T] Pathology Department, Hospital de Tortosa Verge de la Cinta and IISPV, URV, Reus, Spain.
Keywords: Células dendríticas;Progresión de la enfermedad;Enfermedad de Hodgkin;Huésped inmunocomprometido;Macrófagos;Células de Reed-Sternberg;Microambiente tumoral
metadata.dc.subject.mesh: Medical Subject Headings::Anatomy::Cells::Antigen-Presenting Cells::Dendritic Cells
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Progression
Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Lymphoma::Hodgkin Disease
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immunocompromised Host
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy
Medical Subject Headings::Anatomy::Cells::Blood Cells::Leukocytes::Leukocytes, Mononuclear::Lymphocytes::Killer Cells, Natural
Medical Subject Headings::Anatomy::Cells::Blood Cells::Leukocytes::Leukocytes, Mononuclear::Lymphocytes
Medical Subject Headings::Anatomy::Cells::Connective Tissue Cells::Macrophages
Medical Subject Headings::Anatomy::Cells::Blood Cells::Leukocytes::Granulocytes::Neutrophils
Medical Subject Headings::Anatomy::Cells::Reed-Sternberg Cells
Medical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immune System Processes::Tumor Escape
Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cellular Microenvironment::Tumor Microenvironment
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines
Issue Date: 2012
Publisher: Hindawi Publishing Corporation
Citation: de la Cruz-Merino L, Lejeune M, Nogales Fernández E, Henao Carrasco F, Grueso López A, Illescas Vacas A, et al. Role of immune escape mechanisms in Hodgkin's lymphoma development and progression: a whole new world with therapeutic implications. Clin. Dev. Immunol. 2012; 2012:756353
Abstract: Hodgkin's lymphoma represents one of the most frequent lymphoproliferative syndromes, especially in young population. Although HL is considered one of the most curable tumors, a sizeable fraction of patients recur after successful upfront treatment or, less commonly, are primarily resistant. This work tries to summarize the data on clinical, histological, pathological, and biological factors in HL, with special emphasis on the improvement of prognosis and their impact on therapeutical strategies. The recent advances in our understanding of HL biology and immunology show that infiltrated immune cells and cytokines in the tumoral microenvironment may play different functions that seem tightly related with clinical outcomes. Strategies aimed at interfering with the crosstalk between tumoral Reed-Sternberg cells and their cellular partners have been taken into account in the development of new immunotherapies that target different cell components of HL microenvironment. This new knowledge will probably translate into a change in the antineoplastic treatments in HL in the next future and hopefully will increase the curability rates of this disease.
Description: Journal Article; Review;
metadata.dc.identifier.doi: 10.1155/2012/756353
ISSN: 1740-2530 (Online)
1740-2522 (Print)
Appears in Collections:01- Artículos - Hospital Virgen Macarena

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