Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/2081
Título : Effect of statin therapy in the outcome of bloodstream infections due to Staphylococcus aureus: a prospective cohort study.
Autor : López-Cortés, Luis E
Gálvez-Acebal, Juan
Del Toro, María D
Velasco, Carmen
de Cueto, Marina
Caballero, Francisco J
Muniain, Miguel A
Pascual, Alvaro
Rodríguez-Baño, Jesús
Filiación: [López-Cortés,LE; Gálvez-Acebal,J; Del Toro,MD; Velasco,C; de Cueto,M; Muniain,MA; Pascual,A; Rodríguez-Baño,J] Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario Virgen Macarena, Seville, Spain. [Caballero,FJ; Gálvez-Acebal,J; Del Toro,MD; Velasco,C; de Cueto,M; Muniain,MA; Pascual,A; Rodríguez-Baño,J] Spanish Network for Research in Infectious Diseases, Instituto de Salud Carlos III, Madrid, Spain. [Velasco,C; Pascual,A] Departamento de Microbiología, Universidad de Sevilla, Seville, Spain. [Gálvez-Acebal,J; Del Toro,MD; Muniain,MA; Rodríguez-Baño,J] Departamento de Medicina, Universidad de Sevilla, Seville, Spain.
Palabras clave : Antibacterianos
Bacteriemia
Inhibidores de Hidroximetilglutaril-CoA Reductasas
Modelos de Riesgos Proporcionales
Choque Séptico
Infecciones Estafilocócicas
Análisis de Supervivencia
MeSH: Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Anti-Bacterial Agents
Medical Subject Headings::Diseases::Bacterial Infections and Mycoses::Bacterial Infections::Bacteremia
Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Antimetabolites::Hypolipidemic Agents::Anticholesteremic Agents::Hydroxymethylglutaryl-CoA
Medical Subject Headings::Check Tags::Male
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models, Statistical::Proportional Hazards Models
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective Studies
Medical Subject Headings::Diseases::Bacterial Infections and Mycoses::Infection::Sepsis::Shock, Septic
Medical Subject Headings::Diseases::Bacterial Infections and Mycoses::Bacterial Infections::Gram-Positive Bacterial Infections::Staphylococcal Infections
Medical Subject Headings::Organisms::Bacteria::Endospore-Forming Bacteria::Gram-Positive Endospore-Forming Bacteria::Gram-Positive Endospore-Forming Rods::Staphylococcaceae::Staphylococcus::Staphylococcus aureus
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Survival Analysis
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis::Treatment Outcome
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Aged
Medical Subject Headings::Health Care::Health Care Quality, Access, and Evaluation::Delivery of Health Care::Tertiary Healthcare
Fecha de publicación : 23-Dec-2013
Editorial : Public Library of Science
Cita Bibliográfica: López-Cortés LE, Gálvez-Acebal J, Del Toro MD, Velasco C, de Cueto M, Caballero FJ, et al. Effect of statin therapy in the outcome of bloodstream infections due to Staphylococcus aureus: a prospective cohort study. PLoS ONE. 2013; 8(12):e82958
Abstract: INTRODUCTION Statins have pleiotropic effects that could influence the prevention and outcome of some infectious diseases. There is no information about their specific effect on Staphylococcus aureus bacteremia (SAB). METHODS A prospective cohort study including all SAB diagnosed in patients aged ≥18 years admitted to a 950-bed tertiary hospital from March 2008 to January 2011 was performed. The main outcome variable was 14-day mortality, and the secondary outcome variables were 30-day mortality, persistent bacteremia (PB) and presence of severe sepsis or septic shock at diagnosis of SAB. The effect of statin therapy at the onset of SAB was studied by multivariate logistic regression and Cox regression analysis, including a propensity score for statin therapy. RESULTS We included 160 episodes. Thirty-three patients (21.3%) were receiving statins at the onset of SAB. 14-day mortality was 21.3%. After adjustment for age, Charlson index, Pitt score, adequate management, and high risk source, statin therapy had a protective effect on 14-day mortality (adjusted OR = 0.08; 95% CI: 0.01-0.66; p = 0.02), and PB (OR = 0.89; 95% CI: 0.27-1.00; p = 0.05) although the effect was not significant on 30-day mortality (OR = 0.35; 95% CI: 0.10-1.23; p = 0.10) or presentation with severe sepsis or septic shock (adjusted OR = 0.89; CI 95%: 0.27-2.94; p = 0.8). An effect on 30-day mortality could neither be demonstrated on Cox analysis (adjusted HR = 0.5; 95% CI: 0.19-1.29; p = 0.15). CONCLUSIONS Statin treatment in patients with SAB was associated with lower early mortality and PB. Randomized studies are necessary to identify the role of statins in the treatment of patients with SAB.
Descripción : Journal Article;
URI: http://hdl.handle.net/10668/2081
Versión del editor : http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0082958#abstract0
DOI: 10.1371/journal.pone.0082958
ISSN : 1932-6203 (Online)
Appears in Collections:01- Artículos - Hospital Virgen Macarena

Files in This Item:
File Description SizeFormat 
López_EffectStatinTherapy.pdfArtículo publicado224,61 kBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons