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Título : Prognosis Relevance of Serum Cytokines in Pancreatic Cancer.
Autor : Torres, Carolina
Linares, Ana
Alejandre, Maria José
Palomino-Morales, Rogelio J
Caba, Octavio
Prados, Jose
Aránega, Antonia
Delgado, Juan R
Irigoyen, Antonio
Martínez-Galán, Joaquina
Ortuño, Francisco M
Rojas, Ignacio
Perales, Sonia
Filiación: [Torres,C; Linares,A; Alejandre,MJ; Palomino-Morales,RJ; Perales,S] Department of Biochemistry and Molecular Biology I, University of Granada, Granada, Spain. [Caba,O] Department of Health Sciences, University of Jaen, Jaen, Spain. [Prados,J; Aránega,A] Department of Human Anatomy and Embryology, University of Granada, Granada, Spain. [Delgado,JR; Irigoyen,A; Martínez-Galán,J] Oncology Service, Virgen de las Nieves Hospital, Granada, Spain. [Ortuño,FM; Rojas,I] Department of Computer Architecture and Computer Technology (CITIC-UGR), University of Granada, Granada, Spain
Palabras clave : Marcadores biológicos
Carcinoma ductal pancreático
Neoplasias pancreáticas
Modelos de riesgos proporcionales
Timidina fosforilasa
Factor de crecimiento endotelial vascular derivado de glándulas endocrinas
MeSH: Medical Subject Headings::Chemicals and Drugs::Biological Factors::Biological Markers
Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Endocrine Gland Neoplasms::Pancreatic Neoplasms::Carcinoma, Pancreatic Ductal
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines
Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Pyrimidines::Pyrimidine Nucleosides::Cytidine::Deoxycytidine
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Pancreatic Neoplasms
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models, Statistical::Proportional Hazards Models
Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Glycosyltransferases::Pentosyltransferases::Pyrimidine Phosphorylases::Thymidine Phosphorylase
Fecha de publicación : 2015
Editorial : Hindawi Publishing Corporation
Cita Bibliográfica: Torres C, Linares A, Alejandre MJ, Palomino-Morales RJ, Caba O, Prados J, et al. Prognosis Relevance of Serum Cytokines in Pancreatic Cancer. Biomed Res Int; 2015:518284
Abstract: The overall survival of patients with pancreatic ductal adenocarcinoma is extremely low. Although gemcitabine is the standard used chemotherapy for this disease, clinical outcomes do not reflect significant improvements, not even when combined with adjuvant treatments. There is an urgent need for prognosis markers to be found. The aim of this study was to analyze the potential value of serum cytokines to find a profile that can predict the clinical outcome in patients with pancreatic cancer and to establish a practical prognosis index that significantly predicts patients' outcomes. We have conducted an extensive analysis of serum prognosis biomarkers using an antibody array comprising 507 human cytokines. Overall survival was estimated using the Kaplan-Meier method. Univariate and multivariate Cox's proportional hazard models were used to analyze prognosis factors. To determine the extent that survival could be predicted based on this index, we used the leave-one-out cross-validation model. The multivariate model showed a better performance and it could represent a novel panel of serum cytokines that correlates to poor prognosis in pancreatic cancer. B7-1/CD80, EG-VEGF/PK1, IL-29, NRG1-beta1/HRG1-beta1, and PD-ECGF expressions portend a poor prognosis for patients with pancreatic cancer and these cytokines could represent novel therapeutic targets for this disease.
Descripción : Journal Article;
Versión del editor :
DOI: 10.1155/2015/518284
ISSN : 2314-6141 (Online)
Appears in Collections:01- Artículos - Hospital Virgen de las Nieves

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