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Title: Antioxidant Intake and Antitumor Therapy: Toward Nutritional Recommendations for Optimal Results.
Authors: Mut-Salud, Nuria
Álvarez, Pablo Juan
Garrido, Jose Manuel
Carrasco, Esther
Aránega, Antonia
Rodríguez-Serrano, Fernando
metadata.dc.contributor.authoraffiliation: [Mut-Salud,N; Álvarez,PJ; Carrasco,E; Aránega,A; Rodríguez-Serrano,F] Institute of Biopathology and Regenerative Medicine, University of Granada, Granada, Spain. [Garrido,JM] Department of Cardiovascular Surgery, Virgen de las Nieves Hospital, Granada, Spain.
Keywords: Antineoplásicos;Antioxidantes;Dieta;Suplementos dietéticos;Humanos;Neoplasias;Estrés oxidativo;Sustancias protectoras
metadata.dc.subject.mesh: Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic Agents
Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Antioxidants
Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet
Medical Subject Headings::Technology, Industry, Agriculture::Food and Beverages::Food::Dietary Supplements
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Diseases::Neoplasms
Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Oxidative Stress
Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Protective Agents
Issue Date: 2016
Publisher: Hindawi Publishing Corporation
Citation: Mut-Salud N, Álvarez PJ, Garrido JM, Carrasco E, Aránega A, Rodríguez-Serrano F. Antioxidant Intake and Antitumor Therapy: Toward Nutritional Recommendations for Optimal Results. Oxid Med Cell Longev; 2016:6719534
Abstract: The role of the induction of oxidative stress as the mechanism of action of many antitumor drugs is acquiring an increasing interest. In such cases, the antitumor therapy success may be conditioned by the antioxidants present in our own body, which can be synthesized de novo (endogenous) or incorporated through the diet and nutritional supplements (exogenous). In this paper, we have reviewed different aspects of antioxidants, including their classification, natural sources, importance in diet, consumption of nutritional supplements, and the impact of antioxidants on health. Moreover, we have focused especially on the study of the interaction between antioxidants and antitumor therapy, considering both radiotherapy and chemotherapy. In this regard, we found that the convenience of administration of antioxidants during cancer treatment still remains a very controversial issue. In general terms, antioxidants could promote or suppress the effectiveness of antitumor treatment and even protect healthy tissues against damage induced by oxidative stress. The effects may depend on many factors discussed in the paper. These factors should be taken into consideration in order to achieve precise nutritional recommendations for patients. The evidence at the moment suggests that the supplementation or restriction of exogenous antioxidants during cancer treatment, as appropriate, could contribute to improving its efficiency.
Description: Journal Article; Review;
metadata.dc.identifier.doi: 10.1155/2016/6719534
ISSN: 1942-0994 (Online)
Appears in Collections:01- Artículos - Hospital Virgen de las Nieves

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