Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/2221
Título : Liver Toxicity of Current Antiretroviral Regimens in HIV-Infected Patients with Chronic Viral Hepatitis in a Real-Life Setting: The HEPAVIR SEG-HEP Cohort.
Autor : Neukam, Karin
Mira, José A
Collado, Antonio
Rivero-Juárez, Antonio
Monje-Agudo, Patricia
Ruiz-Morales, Josefa
Ríos, María José
Merino, Dolores
Téllez, Francisco
Pérez-Camacho, Inés
Gálvez-Contreras, María Carmen
Rivero, Antonio
Pineda, Juan A
Filiación: [Neukam,K; Monje-Agudo,P; Pineda,JA] Unit of Infectious Diseases and Microbiology, Hospital Universitario de Valme, Seville, Spain. [Neukam,K; Monje-Agudo,P] Instituto de Biomedicina de Sevilla (IBiS), Seville, Spain. [Mira,JA] Internal Medicine Service, Hospital Universitario de Valme, Seville, Spain. [Collado,A; Rivero-Juárez,A; Gálvez-Contreras,MC] Internal Medicine Department, Hospital Torrecárdenas, Almería, Spain. [Rivero,A] Unit of Infectious Diseases, Hospital Universitario Reina Sofia, Maimonides Institute for Biomedical Research (IMIBIC), University of Cordoba, Cordoba, Spain. [Ruiz Morales,J] Unit of Infectious Diseases, Hospital Universitario Virgen de la Victoria, Málaga, Spain. [Ríos,MJ] Unit of Infectious Diseases, Hospital Universitario Virgen de la Macarena, Seville, Spain. [Merino,D] Internal Medicine Service, Hospital Juan Ramón Jiménez. Huelva, Spain. [Téllez,F] Unit of Infectious Diseases, Hospital de La Línea de la Concepción, Cadiz, Spain. [Pérez-Camacho,I] Unit of Tropical Medicine, Hospital Poniente, El Ejido, Spain.
Palabras clave : Hepatitis B crónica
Bilirrubina
Ciclohexanos
Estudios de seguimiento
Infecciones por VIH
Inhibidores de proteasas
ARN
Inhibidores de la transcriptasa inversa
Transaminasas
MeSH: Medical Subject Headings::Diseases::Virus Diseases::DNA Virus Infections::Hepadnaviridae Infections::Hepatitis B::Hepatitis B, Chronic
Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Azoles::Pyrroles::Tetrapyrroles::Bile Pigments::Bilirubin
Medical Subject Headings::Diseases::Bacterial Infections and Mycoses::Infection::Coinfection
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons, Cyclic::Hydrocarbons, Alicyclic::Cycloparaffins::Cyclohexanes
Medical Subject Headings::Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Follow-Up Studies
Medical Subject Headings::Diseases::Virus Diseases::RNA Virus Infections::Retroviridae Infections::Lentivirus Infections::HIV Infections
Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Enzyme Inhibitors::Protease Inhibitors
Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::RNA
Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Enzyme Inhibitors::Nucleic Acid Synthesis Inhibitors::Reverse Transcriptase Inhibitors
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Sulfur Compounds::Thiazoles::Ritonavir
Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Nitrogenous Group Transferases::Transaminases
Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Azoles::Triazoles
Fecha de publicación : 5-Feb-2016
Editorial : Public Library of Science
Cita Bibliográfica: Neukam K, Mira JA, Collado A, Rivero-Juárez A, Monje-Agudo P, Ruiz-Morales J, et al. Liver Toxicity of Current Antiretroviral Regimens in HIV-Infected Patients with Chronic Viral Hepatitis in a Real-Life Setting: The HEPAVIR SEG-HEP Cohort. PLoS ONE. 2015; 11(2):e0148104
Abstract: OBJECTIVE To assess the current frequency of ART-associated grade 3-4 transaminase elevations (TE) and grade 4 total bilirubin elevations (TBE) in HIV-infected patients with chronic hepatitis B and/or C, who start a new regimen of ART. PATIENTS AND METHODS A total of 192 pre-treated or treatment-naive HIV infected patients with HBV and/or HCV-coinfection who started ART in eight Southern Spanish centers from July/2011-December/2013, were followed for 12 months in this prospective study. RESULTS Forty-one (21.4%) subjects had been naïve to ART, median (IQR) follow-up was 11.6 (5.6-12.9) months. The most frequently initiated NRTI were tenofovir/emtricitabine [49 patients (25.5%)]. Eighty-nine (46.4%) patients started a ritonavir-boosted protease inhibitor and 77 (40.1%) individuals a NNRTI. Raltegravir and maraviroc were initiated in 24 (12.5%) and 9 (4.7%) individuals. Ten [5.21%; 95% confidence interval (CI): 2.53%-9.37%] patients presented grade 3 TE, while 8 (4.17%; 95%CI: 1.82%-8.04%) subjects showed grade 4 TBE. No episodes of grade 4 TE or ART discontinuation due to hepatotoxic events were observed. The use of ritonavir-boosted atazanavir was the only independent predictor for grade 4 TBE [adjusted odds ratio: 7.327 (95%CI: 1.417-37.89); p = 0.018] in an analysis adjusted for age, sex and baseline HIV-RNA levels, while no factor could be independently associated with grade 3-4 TE. CONCLUSIONS Currently, the frequency of severe ART-associated TE and TBE under real-life conditions in patients with chronic viral hepatitis is similar to what has been reported previously. However, episodes of grade 4 TE are less frequent and severe TE appears to be of lesser concern.
Descripción : Journal Article;
URI: http://hdl.handle.net/10668/2221
Versión del editor : http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0148104
DOI: 10.1371/journal.pone.0148104
ISSN : 1932-6203 (Online)
Appears in Collections:01- Artículos - APES Hospital de Poniente
01- Artículos - AGS Campo de Gibraltar
01- Artículos - Hospital Juan Ramón Jiménez
01- Artículos - Hospital Virgen Macarena
01- Artículos - IMIBIC. Instituto Maimónides de Investigación Biomédica de Córdoba
01- Artículos - Hospital Reina Sofía
01- Artículos - Complejo Hospitalario Torrecárdenas
01- Artículos - IBIS. Instituto de Biomedicina de Sevilla
01- Artículos - Hospital de Valme
01- Artículos - Hospital Virgen de la Victoria

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