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Title: The urgent need to recover MHC class I in cancers for effective immunotherapy.
Authors: Garrido, Federico
Aptsiauri, Natalia
Doorduijn, Elien M
Garcia Lora, Angel M
van Hall, Thorbald
metadata.dc.contributor.authoraffiliation: [Garrido,F] Departamento de Bioquimica, Biologia Molecular III e Inmunologia, Facultad de Medicina, Universidad de Granada, Granada, Spain. [Garrido,F] Aptsiauri,N; Garcia Lora,AM] Servicio de Análisis Clínicos, UGC de Laboratorio Clínico, Hospital Universitario Virgen de las Nieves, Granada, Spain. [Garrido,F] Aptsiauri,N; Garcia Lora,AM] Instituto de Investigacion Biosanitaria de Granada (IBS.Granada), Granada, Spain. [Doorduijn,E; van Hall,T] Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands.
Keywords: Presentación de antígeno;Genes clase I del complejo de histocompatibilidad (MHC);Antígenos de histocompatibilidad clase I;Humanos;Inmunoterapia;Neoplasias;Linfocitos T;Escape del tumor;Regulación hacia arriba
metadata.dc.subject.mesh: Medical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immune System Processes::Antigen Presentation
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Major Histocompatibility Complex::Genes, MHC Class I
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Glycoproteins::Membrane Glycoproteins::Histocompatibility Antigens Class I
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy
Medical Subject Headings::Diseases::Neoplasms
Medical Subject Headings::Anatomy::Cells::Blood Cells::Leukocytes::Leukocytes, Mononuclear::Lymphocytes::T-Lymphocytes
Medical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immune System Processes::Tumor Escape
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Up-Regulation
Issue Date: Apr-2016
Publisher: Elsevier
Citation: Garrido F, Aptsiauri N, Doorduijn EM, Garcia Lora AM, van Hall T. The urgent need to recover MHC class I in cancers for effective immunotherapy. Curr. Opin. Immunol.. 2016 ; 39:44-51
Abstract: Immune escape strategies aimed to avoid T-cell recognition, including the loss of tumor MHC class I expression, are commonly found in malignant cells. Tumor immune escape has proven to have a negative effect on the clinical outcome of cancer immunotherapy, including treatment with antibodies blocking immune checkpoint molecules. Hence, there is an urgent need to develop novel approaches to overcome tumor immune evasion. MHC class I antigen presentation is often affected in human cancers and the capacity to induce upregulation of MHC class I cell surface expression is a critical step in the induction of tumor rejection. This review focuses on characterization of rejection, escape, and dormant profiles of tumors and its microenvironment with a special emphasis on the tumor MHC class I expression. We also discuss possible approaches to recover MHC class I expression on tumor cells harboring reversible/'soft' or irreversible/'hard' genetic lesions. Such MHC class I recovery approaches might well synergize with complementary forms of immunotherapy.
Description: Journal Article; Review;
metadata.dc.identifier.doi: 10.1016/j.coi.2015.12.007
ISSN: 1879-0372 (Online)
0952-7915 (Print)
Appears in Collections:01- Artículos - Hospital Virgen de las Nieves
01- Artículos - ibsGRANADA. Instituto de Investigación Biosanitaria de Granada

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