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Title: Differential Plasma-cell evolution is linked with Dermatophagoides pteronyssinus immunotherapy response.
Authors: Fernández, Tahia D
Gómez, Enrique
Doña, Inmaculada
Campo, Paloma
Rondon, Carmen
Gonzalez, Miguel
Gomez, Francisca
Palomares, Francisca
Salas, Maria
Blanca, Miguel
Mayorga, Cristobalina
Torres, Maria J
metadata.dc.contributor.authoraffiliation: [Fernández,TD; Gómez,E; Gonzalez,M; Palomares,F; Mayorga,C] Research Laboratory-Allergy Unit, IBIMA-Regional University Hospital of Malaga, UMA, Malaga, Spain. [Doña,I; Campo,P; Rondon,C; Gomez,F; Salas,M; Blanca,M; Mayorga,C; Torres,MJ] Allergy Service, IBIMA-Regional University Hospital of Malaga, UMA, Malaga, Spain.
Keywords: Alérgenos;Linfocitos B;Desensibilización inmunológica;Inmunoglobulina G;Células plasmáticas;Rinitis alérgica;Linfocitos T
metadata.dc.subject.mesh: Medical Subject Headings::Chemicals and Drugs::Biological Factors::Antigens::Allergens
Medical Subject Headings::Anatomy::Hemic and Immune Systems::Immune System::Antibody-Producing Cells::B-Lymphocytes
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Immunologic Techniques::Immunosuppression::Desensitization, Immunologic
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Globulins::Serum Globulins::Immunoglobulins::Antibodies::Immunoglobulin Isotypes::Immunoglobulin G
Medical Subject Headings::Anatomy::Cells::Antibody-Producing Cells::B-Lymphocytes::Plasma Cells
Medical Subject Headings::Diseases::Respiratory Tract Diseases::Nose Diseases::Rhinitis
Medical Subject Headings::Anatomy::Cells::Blood Cells::Leukocytes::Leukocytes, Mononuclear::Lymphocytes::T-Lymphocytes
Issue Date: 29-Sep-2015
Publisher: Nature Publishing Group
Citation: Fernández TD, Gómez E, Doña I, Campo P, Rondon C, Gonzalez M, et al. Differential Plasma-cell evolution is linked with Dermatophagoides pteronyssinus immunotherapy response. Sci Rep. 2015; 5:14482
Abstract: Allergic rhinitis is highly prevalent worldwide. Immunotherapy has been shown to control its symptoms, however, up to 30% of patients may not respond. Previous studies of the immunological mechanisms involved in allergen-immunotherapy (AIT) have focused on the humoral and T-cell response and several studies have evaluated some B-cell subpopulations during AIT and their role in immunological tolerance. However, although B and plasma-cell subpopulations are two of the most important cellular subtypes involved in allergic reactions, their relation with AIT efficacy remains unelucidated. The objective was to analyze the effects of immunotherapy on different B and plasma-cell subpopulations and whether these changes correlate with the clinical response to the treatment. Although no changes are found in B-cell subpopulations, responder patients show increased levels of memory B-cells even before the beginning of treatment. Changes in plasma-cell subpopulations are found, mainly in circulating inflammatory plasma-cells that could affect the response to the allergen. Moreover, an early increase of specific-IgG4 and IgG4 secreting-cells was found. All these suggest that the determination of the memory B-cells before the initiation of the treatment, and the quantification of IgG4 and IgG4-secreting-cells in the first months of immunotherapy, could serve as markers for the clinical response to treatment.
Description: Journal Article; Research Support, Non-U.S. Gov't;
metadata.dc.identifier.doi: 10.1038/srep14482
ISSN: 2045-2322 (Online)
Appears in Collections:01- Artículos - Hospital Regional de Málaga
01- Artículos - IBIMA. Instituto de Investigación Biomédica de Málaga

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