Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/2291
Título : Quality of life in patients with lower urinary tract symptoms associated with BPH: change over time in real-life practice according to treatment-the QUALIPROST study.
Autor : Alcaraz, Antonio
Carballido-Rodríguez, Joaquín
Unda-Urzaiz, Miguel
Medina-López, Rafael
Ruiz-Cerdá, José L
Rodríguez-Rubio, Federico
García-Rojo, Darío
Brenes-Bermúdez, Francisco J
Cózar-Olmo, José M
Baena-González, Víctor
Manasanch, José
Filiación: [Alcaraz,A] Urology Department, Hosp. Clínic Univ., IDIBAPS, Barcelona, Spain . [Carballido-Rodríguez,J] Urology Department, Hosp. Univ. Puerta de Hierro, Majadahonda, Madrid, Spain. [Unda-Urzaiz,M] Urology Department, Hosp. Univ. Basurto, Bilbao, Spain. [Medina-López,R] Urology Department, Hosp. Univ. Virgen del Rocío, Sevilla, Spain. [Ruiz-Cerdá,JL] Urology Department, Hosp. Univ. La Fe, Valencia, Spain. [Rodríguez-Rubio,F] Department, Hosp. Univ. Puerto Real, Cádiz, Spain. [García-Rojo,D] Urology Department, Hosp. Univ. Parc Taulí Sabadell, Sabadell, Barcelona, Spain. [Brenes-Bermúdez,FJ] Llefià Primary Care Center, Badalona, Barcelona, Spain. [Cózar-Olmo,JM] Urology Department, Complejo Hospitalario Universitario de Granada, Granada, Spain. [Baena-González,V]Urology Department, Hosp. Univ. Carlos Haya, Málaga, Spain.[Manasanch,J] Pierre Fabre Ibérica S.A., Barcelona, Spain.
Palabras clave : LUTS
BPH
Quality of life
Real-life practice
BII
IPSS
Inhibidores de 5-alfa-reductasa
Antagonistas adrenérgicos alfa
Instituciones de atención ambulatoria
Síntomas del sistema urinario inferior
Oxidorreductasas
Fitoterapia
Extractos vegetales
Estudios prospectivos
Hiperplasia prostática
Calidad de vida
Serenoa
Urología
Espera vigilante
MeSH: Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Enzyme Inhibitors::5-alpha Reductase Inhibitors
Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Neurotransmitter Agents::Adrenergic Agents::Adrenergic Antagonists::Adrenergic alpha-Antagonists
Medical Subject Headings::Health Care::Health Care Facilities, Manpower, and Services::Health Facilities::Ambulatory Care Facilities
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Urological Manifestations::Lower Urinary Tract Symptoms
Medical Subject Headings::Check Tags::Male
Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Oxidoreductases
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Complementary Therapies::Phytotherapy
Medical Subject Headings::Chemicals and Drugs::Complex Mixtures::Biological Agents::Plant Preparations::Plant Extracts
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective Studies
Medical Subject Headings::Diseases::Male Urogenital Diseases::Genital Diseases, Male::Prostatic Diseases::Prostatic Hyperplasia
Medical Subject Headings::Disciplines and Occupations::Social Sciences::Quality of Life
Medical Subject Headings::Organisms::Eukaryota::Plants::Viridiplantae::Streptophyta::Embryophyta::Angiosperms::Arecaceae::Serenoa
Medical Subject Headings::Disciplines and Occupations::Health Occupations::Medicine::Specialties, Surgical::Urology
Medical Subject Headings::Health Care::Health Services Administration::Quality of Health Care::Outcome and Process Assessment (Health Care)::Outcome Assessment (Health Care)::Watchful Waiting
Fecha de publicación : May-2016
Editorial : Springer Verlag
Cita Bibliográfica: Alcaraz A, Carballido-Rodríguez J, Unda-Urzaiz M, Medina-López R, Ruiz-Cerdá JL, Rodríguez-Rubio F, et al. Quality of life in patients with lower urinary tract symptoms associated with BPH: change over time in real-life practice according to treatment-the QUALIPROST study. Int Urol Nephrol. 2016; 48(5):645-56
Abstract: PURPOSE To evaluate change in quality of life (QoL) and symptoms in patients with lower urinary tract symptoms/benign prostatic hyperplasia (LUTS/BPH) in conditions of current clinical practice. METHODS Prospective, longitudinal, multicenter open-label study was carried out in urology outpatient clinics. Patients were ≥40 years of age with an International Prostate Symptom Score (IPSS) score ≥8. QoL and symptoms were measured at baseline and 6 months using the Benign Prostatic Hyperplasia Impact Index (BII) and the IPSS. RESULTS 1713 patients were included for analysis. Mean (SD) IPSS and BII scores at baseline were 16.8 (5.4) and 6.8 (2.6), respectively. 8.9 % (n = 153) of study participants did not receive treatment (watchful waiting, WW), 70.3 % (n = 1204) were prescribed monotherapy (alpha-adrenergic blockers [AB]; phytotherapy [PT, of which 95.2 % was the hexanic extract of Serenoa repens, HESr]; or 5-alpha-reductase inhibitors [5ARI]), and 20.8 % (n = 356) received combined treatment (AB + 5ARI; AB + HESr; others). At 6 months, improvements in QoL were similar across the different medical treatment (MT) groups, both for monotherapy (AB: mean improvement [SD] of 2.4 points [2.4]; PT: 1.9 [2.4]; 5ARI: 2.5 [2.3]) and combined therapy (AB + 5ARI: 3.1 [2.9]; AB + PT: 3.1 [2.5]). There were no clinically significant differences between MT groups and all showed significant improvement over WW (p < 0.05). HESr showed similar efficacy to AB and 5ARI both as monotherapy and in combination with AB. Results on the IPSS were similar. CONCLUSIONS Improvements in QoL and symptoms were equivalent across the medical treatments most widely used in real-life practice to manage patients with moderate or severe LUTS. HESr showed an equivalent efficacy to AB and 5ARI with fewer side effects.
Descripción : Journal Article;
URI: http://hdl.handle.net/10668/2291
Versión del editor : http://link.springer.com/article/10.1007%2Fs11255-015-1206-7#Abs1
DOI: 10.1007/s11255-015-1206-7
ISSN : 1573-2584 (Online)
0301-1623 (Print)
Appears in Collections:01- Artículos - Complejo Hospitalario Universitario de Granada
01- Artículos - Hospital Regional de Málaga
01- Artículos - Hospital de Puerto Real
01- Artículos - Hospital Virgen del Rocío

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