Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/2316
Título : Lack of validation of genetic variants associated with anti-tumor necrosis factor therapy response in rheumatoid arthritis: a genome-wide association study replication and meta-analysis.
Autor : Márquez, Ana
Ferreiro-Iglesias, Aida
Dávila-Fajardo, Cristina L
Montes, Ariana
Pascual-Salcedo, Dora
Perez-Pampin, Eva
Moreno-Ramos, Manuel J
García-Portales, Rosa
Navarro, Federico
Moreira, Virginia
Magro, César
Caliz, Rafael
Ferrer, Miguel Angel
Alegre-Sancho, Juan José
Joven, Beatriz
Carreira, Patricia
Balsa, Alejandro
Vasilopoulos, Yiannis
Sarafidou, Theologia
Cabeza-Barrera, José
Narvaez, Javier
Raya, Enrique
Cañete, Juan D
Fernández-Nebro, Antonio
Ordóñez, María del Carmen
de la Serna, Arturo R
Magallares, Berta
Gomez-Reino, Juan J
González, Antonio
Martín, Javier
Filiación: [Márquez,A; Dávila-Fajardo,CL; Martín,J] Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas (CSIC), Armilla, Granada, Spain. [Ferreiro-Iglesias,A; Montes,A; Perez-Pampin,E; Gomez-Reino,JJ; González,A] Laboratorio Investigación 10 and Rheumatology Unit, Instituto de Investigación Sanitaria-Hospital Clínico Universitario de Santiago, Santiago de Compostela, Spain. [Dávila-Fajardo,CL; Cabeza-Barrera,J] Department of Clinical Pharmacy, Hospital Universitario San Cecilio, Instituto de Investigación Biosanitaria de Granada (IBIG), Granada, Spain. [Pascual-Salcedo,D] Department of Immunology, Instituto de Investigación Sanitaria del Hospital Universitario La Paz (IdiPAZ),Research Network in Inflammation and Rheumatic Diseases (RIER), Hospital La Paz, Madrid, Spain. [Moreno-Ramos,MJ] Department of Rheumatology, Hospital Virgen de la Arrixaca,El Palmar Murcia, Spain. [García-Portales,R] Department of Rheumatology, Hospital Virgen de la Victoria, Campus de Teatinos Málaga, Spain. [Navarro,F; Moreira,V] Rheumatology Unit, Hospital Universitario Virgen Macarena, Sevilla, Spain. [Magro,C] Department of Rheumatology, Hospital Clínico San Cecilio, Granada, Spain. [Caliz,R; Ferrer,MA] Rheumatology Unit, Hospital Universitario Virgen de las Nieves, Granada, Spain. [Alegre-Sancho,JJ] Department of Rheumatology, Hospital Doctor Peset, Valencia, Spain. [Joven,B; Carreira,P] Department of Rheumatology, Instituto de Investigación I+12, Research Network in Inflammation and Rheumatic Diseases (RIER), Hospital Universitario 12 de Octubre, Madrid, Spain. [Balsa,A] Department of Rheumatology, Instituto de Investigación Sanitaria del Hospital Universitario La Paz (IdiPAZ), Research Network in Inflammation and Rheumatic Diseases (RIER), Madrid, Spain. [Vasilopoulos,Y; Sarafidou,T] Department of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece. [Narvaez,J] Rheumatology Department, Hospital Universitario de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain. [Cañete,JD] Rheumatology Department, Hospital Clinic and Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain. [Fernández-Nebro,A; Ordóñez,MC] Unidad de Gestión Clínica (UGC) Rheumatology, Hospital Regional Universitario de Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain. [de la Serna,AR; Magallares,B] Rheumatology Unit, Hospital Santa Creu e San Pau, Barcelona, Spain. [Gomez-Reino,JJ] Department of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain.
Palabras clave : Antirreumáticos
Artritis reumatoide
Estudio de asociación del genoma completo
Genotipo
Polimorfismo de nucleótido simple
Resultado del tratamiento
Factor de necrosis tumoral alfa
MeSH: Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antirheumatic Agents
Medical Subject Headings::Diseases::Skin and Connective Tissue Diseases::Connective Tissue Diseases::Rheumatic Diseases::Arthritis, Rheumatoid
Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Genetic Association Studies::Genome-Wide Association Study
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype
Medical Subject Headings::Check Tags::Male
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic::Polymorphism, Single Nucleotide
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Chemicals and Drugs::Biological Factors::Intercellular Signaling Peptides and Proteins::Tumor Necrosis Factors::Tumor Necrosis Factor-alpha
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Aged
Fecha de publicación : 11-Mar-2014
Editorial : BioMed Central
Cita Bibliográfica: Márquez A, Ferreiro-Iglesias A, Dávila-Fajardo CL, Montes A, Pascual-Salcedo D, Perez-Pampin E, et al. Lack of validation of genetic variants associated with anti-tumor necrosis factor therapy response in rheumatoid arthritis: a genome-wide association study replication and meta-analysis. Arthritis Res. Ther. 2014; 16(2):R66
Abstract: INTRODUCTION In this study, our aim was to elucidate the role of four polymorphisms identified in a prior large genome-wide association study (GWAS) in which the investigators analyzed the responses of patients with rheumatoid arthritis (RA) to treatment with tumor necrosis factor inhibitors (TNFi). The authors of that study reported that the four genetic variants were significantly associated. However, none of the associations reached GWAS significance, and two subsequent studies failed to replicate these associations. METHODS The four polymorphisms (rs12081765, rs1532269, rs17301249 and rs7305646) were genotyped in a total of 634 TNFi-treated RA patients of Spanish Caucasian origin. Four outcomes were evaluated: changes in the Disease Activity Score in 28 joints (DAS28) after 6 and 12 months of treatment and classification according to the European League Against Rheumatism (EULAR) response criteria at the same time points. Association with DAS28 changes was assessed by linear regression using an additive genetic model. Contingency tables of genotype and allele frequencies between EULAR responder and nonresponder patients were compared. In addition, we combined our data with those of previously reported studies in a meta-analysis including 2,998 RA patients. RESULTS None of the four genetic variants showed an association with response to TNFi in any of the four outcomes analyzed in our Spanish patients. In addition, only rs1532269 yielded a suggestive association (P = 0.0033) with the response to TNFi when available data from previous studies were combined in the meta-analysis. CONCLUSION Our data suggest that the rs12081765, rs1532269, rs17301249 and rs7305646 genetic variants do not have a role as genetic predictors of TNFi treatment outcomes.
Descripción : Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't;
URI: http://hdl.handle.net/10668/2316
Versión del editor : http://arthritis-research.biomedcentral.com/articles/10.1186/ar4504#Abs1
DOI: 10.1186/ar4504
ISSN : 1478-6362 (Online)
1478-6354 (Print)
Appears in Collections:01- Artículos - Hospital Virgen de la Victoria
01- Artículos - IBIMA. Instituto de Investigación Biomédica de Málaga
01- Artículos - Hospital Regional de Málaga
01- Artículos - Hospital Virgen Macarena
01- Artículos - ibsGRANADA. Instituto de Investigación Biosanitaria de Granada
01- Artículos - Hospital San Cecilio
01- Artículos - Hospital Virgen de las Nieves

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