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Title: Circulating irisin levels are positively associated with metabolic risk factors in sedentary subjects.
Authors: Moreno, María
Moreno-Navarrete, José María
Serrano, Marta
Ortega, Francisco
Delgado, Elías
Sanchez-Ragnarsson, Cecilia
Valdés, Sergio
Botas, Patricia
Ricart, Wifredo
Fernández-Real, José Manuel
metadata.dc.contributor.authoraffiliation: [Moreno,M; Moreno-Navarrete,JM; Serrano,M; Ortega,F; Ricart,W; Fernández-Real,JM] Department of Diabetes, Endocrinology and Nutrition, Institut d’Investigació Biomèdica de Girona (IdIBGi), CIBEROBN (CB06/03/010) and Instituto de Salud Carlos III (ISCIII), Girona, Spain. [Delgado,E; Sanchez-Ragnarsson,C] Department of Endocrinology and Nutrition, Hospital Central de Asturias, Oviedo, Spain. [Valdés,S] Endocrinology and Nutrition, Hospital Regional de Málaga, IBIMA, CIBERDEM, Spain. [Botas,P] Department of Medicine, Hospital San Agustin, Aviles, Spain.
Keywords: Enfermedades cardiovasculares;Diabetes mellitus tipo II;Fibronectinas;Resistencia a la insulina;Estudios prospectivos;Factores de riesgo;Población rural;Vida sedentaria
metadata.dc.subject.mesh: Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Aged
Medical Subject Headings::Diseases::Cardiovascular Diseases
Medical Subject Headings::Diseases::Endocrine System Diseases::Diabetes Mellitus::Diabetes Mellitus, Type 2
Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Membrane Glycoproteins::Fibronectins
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Pharmacological Phenomena::Drug Resistance::Insulin Resistance
Medical Subject Headings::Check Tags::Male
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective Studies
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors
Medical Subject Headings::Health Care::Population Characteristics::Population::Rural Population
Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Psychology, Social::Life Style::Sedentary Lifestyle
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult
Issue Date: 21-Apr-2015
Publisher: Public Library of Science
Citation: Moreno M, Moreno-Navarrete JM, Serrano M, Ortega F, Delgado E, Sanchez-Ragnarsson C, et al. Circulating irisin levels are positively associated with metabolic risk factors in sedentary subjects. PLoS ONE. 2015; 10(4):e0124100
Abstract: INTRODUCTION A physically active life-style plays an independent role in the protection against type 2 diabetes and cardiovascular diseases. Irisin, a novel exercise-induced myokine, activates thermogenesis in rodents through increasing beige fat cells abundance within white fat. We aimed to investigate circulating irisin levels in association with the degree of physical activity and various metabolic parameters in humans. METHODS Circulating irisin levels (ELISA) and metabolic parameters were analyzed in 428 subjects (195 men/233 women). Participants were classified according to their self-reported physical activity and to their area of residence. RESULTS Circulating irisin levels were higher in active than in sedentary subjects (p = 0.006). Rural inhabitants showed higher circulating irisin levels than urban subjects (p < 0.0001). The increase in irisin levels related to an active lifestyle was only observed in rural citizens (p = 0.014). Among sedentary participants, irisin levels were positively associated with metabolic risk factors (BMI, fasting insulin, HOMA and fasting triglycerides). The area of residence (β = - 0.592, p = < 0.0001) contributed independently to circulating irisin levels variance after controlling for age, gender, BMI, HOMAIR, triglycerides and physical activity. CONCLUSIONS In sedentary participants, circulating irisin levels were positively associated with parameters related to an increased cardiometabolic risk. The present study confirmed that an active lifestyle increases circulating irisin levels, but only among subjects living in a rural environment. Area of residence might be a determinant of irisin levels.
Description: Journal Article; Research Support, Non-U.S. Gov't;
metadata.dc.identifier.doi: 10.1371/journal.pone.0124100
ISSN: 1932-6203 (Online)
Appears in Collections:01- Artículos - Hospital Regional de Málaga
01- Artículos - IBIMA. Instituto de Investigación Biomédica de Málaga

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