Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/2337
Título : Systemic administration of oleoylethanolamide protects from neuroinflammation and anhedonia induced by LPS in rats.
Autor : Sayd, Aline
Antón, María
Alén, Francisco
Caso, Javier Rubén
Pavón, Javier
Leza, Juan Carlos
Rodríguez de Fonseca, Fernando
García-Bueno, Borja
Orio, Laura
Filiación: [Anton,M; Alen,F; Rodríguez de Fonseca,F; Orio,L] Department of Psychobiology, Faculty of Psychology, Complutense University, Complutense University of Madrid (UCM), Madrid, Spain. [Said,A; Lez,JC; Garcia-Bueno,B] Department of Pharmacology, Faculty of Medicine, UCM, and Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM)), Madrid, Spain . [Caso,JR] Department of Psychiatry, Faculty of Medicine, UCM, and Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain. [Pavón,J; Rodriguez de Fonseca,F] UGC Salud Mental. Instituto de Investigación Biomédica de Málaga. Hospital Regional Universitario de Málaga.Universidad de Málaga. Red de Trastornos Adictivos, Málaga, Spain.
Palabras clave : OLEA
Lipopolysaccharide
Neuroinflammation
Anhedonia
Antiinflamatorios
Corticosterona
Citocinas
Modelos de enfermedad en animales
Encefalitis
Endocannabinoides
Endotoxinas
Etanolaminas
PEA
Preferencias alimenticias
Lóbulo frontal
Sistema hipotálamo-hipofisario
Mediadores de la inflamación
Peroxidación de lípidos
Fármacos neuroprotectores
Ácidos oleicos
Estrés oxidativo
Ácidos palmíticos
Sistema hipófiso-suprarrenal
Ratas wistar
Percepción del gusto
MeSH: Medical Subject Headings::Organisms::Eukaryota::Animals
Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Inflammatory Agents
Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Behavior, Animal
Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Physiological Processes::Body Temperature Regulation
Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain
Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Adrenal Cortex Hormones::Hydroxycorticosteroids::11-Hydroxycorticosteroids::Corticosterone
Medical Subject Headings::Chemicals and Drugs::Biological Factors::Intercellular Signaling Peptides and Proteins::Cytokines
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models, Animal::Disease Models, Animal
Medical Subject Headings::Diseases::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Encephalitis
Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Neurotransmitter Agents::Endocannabinoids
Medical Subject Headings::Chemicals and Drugs::Biological Factors::Toxins, Biological::Bacterial Toxins::Endotoxins
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Alcohols::Ethanol::Ethanolamines
Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Feeding Behavior::Food Preferences
Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain::Prosencephalon::Telencephalon::Cerebrum::Cerebral Cortex::Frontal Lobe
Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain::Prosencephalon::Diencephalon::Hypothalamus::Hypothalamus, Middle::Hypothalamo-Hypophyseal System
Medical Subject Headings::Chemicals and Drugs::Biological Factors::Inflammation Mediators
Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Energy Metabolism::Oxidation-Reduction::Lipid Peroxidation
Medical Subject Headings::Check Tags::Male
Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Protective Agents::Neuroprotective Agents
Medical Subject Headings::Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids, Unsaturated::Fatty Acids, Monounsaturated::Oleic Acids
Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Physiological Processes::Stress, Physiological::Oxidative Stress
Medical Subject Headings::Chemicals and Drugs::Lipids::Fatty Acids::Palmitic Acids
Medical Subject Headings::Anatomy::Endocrine System::Endocrine Glands::Pituitary-Adrenal System
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats::Rats, Wistar
Medical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Perception::Taste Perception
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Neurologic Manifestations::Neurobehavioral Manifestations::Anhedonia
Fecha de publicación : Apr-2015
Editorial : Oxford University Press
Cita Bibliográfica: Said A, Antón M, Alén F, Caso JR, Pavón J, Leza JC, et al. Systemic Administration of Oleoylethanolamide Protects from Neuroinflammation and Anhedonia Induced by LPS in Rats. Int J Neuropsychopharmacol. 2015; 18 (6). pyu111.
Abstract: BACKGROUND The acylethanolamides oleoylethanolamide and palmitoylethanolamide are endogenous lipid mediators with proposed neuroprotectant properties in central nervous system (CNS) pathologies. The precise mechanisms remain partly unknown, but growing evidence suggests an antiinflammatory/antioxidant profile. METHODS We tested whether oleoylethanolamide/palmitoylethanolamide (10 mg/kg, i.p.) attenuate neuroinflammation and acute phase responses (hypothalamus-pituitary-adrenal (HPA) stress axis stress axis activation, thermoregulation, and anhedonia) induced by lipopolysaccharide (0.5 mg/kg, i.p.) in rats. RESULTS Lipopolysaccharide increased mRNA levels of the proinflammatory cytokines tumor necrosis factor-α, interleukin-1β, and interleukin-6, nuclear transcription factor-κB activity, and the expression of its inhibitory protein IκBα in cytoplasm, the inducible isoforms of nitric oxide synthase and cyclooxygenase-2, microsomal prostaglandin E2 synthase mRNA, and proinflammatory prostaglandin E2 content in frontal cortex 150 minutes after administration. As a result, the markers of nitrosative/oxidative stress nitrites (NO2(-)) and malondialdehyde were increased. Pretreatment with oleoylethanolamide/ palmitoylethanolamide reduced plasma tumor necrosis factor-α levels after lipopolysaccharide, but only oleoylethanolamide significantly reduced brain tumor necrosis factor-α mRNA. Oleoylethanolamide and palmitoylethanolamide prevented lipopolysaccharide-induced nuclear transcription factor-κB (NF-κB)/IκBα upregulation in nuclear and cytosolic extracts, respectively, the expression of inducible isoforms of nitric oxide synthase, cyclooxygenase-2, and microsomal prostaglandin E2 synthase and the levels of prostaglandin E2. Additionally, both acylethanolamides reduced lipopolysaccharide-induced oxidative/nitrosative stress. Neither oleoylethanolamide nor palmitoylethanolamide modified plasma corticosterone levels after lipopolysaccharide, but both acylethanolamides reduced the expression of hypothalamic markers of thermoregulation interleukin-1β, cyclooxygenase-2, and prostaglandin E2, and potentiated the hypothermic response after lipopolysaccharide. Interestingly, only oleoylethanolamide disrupted lipopolysaccharide-induced anhedonia in a saccharine preference test. CONCLUSIONS Results indicate that oleoylethanolamide and palmitoylethanolamide have antiinflammatory/neuroprotective properties and suggest a role for these acylethanolamides as modulators of CNS pathologies with a neuroinflammatory component.
Descripción : Comparative Study; Journal Article; Research Support, Non-U.S. Gov't;Erratium: http://ijnp.oxfordjournals.org/content/19/3/pyw004.long
URI: http://hdl.handle.net/10668/2337
Versión del editor : http://ijnp.oxfordjournals.org/content/18/6/pyu111.long#abstract-1
DOI: 10.1093/ijnp/pyu111
ISSN : 1469-5111 (Online)
1461-1457 (Print)
Appears in Collections:01- Artículos - IBIMA. Instituto de Investigación Biomédica de Málaga
01- Artículos - Hospital Regional de Málaga

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