Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/2347
Título : Dimension of chronic hepatitis C virus in HIV-infected patients in the interferon-free era: an overview from south Spain.
Autor : Rivero-Juarez, A
Gutierrez-Valencia, A
Castaño, M
Merino, D
Neukam, K
Ríos-Villegas, M J
Lopez-Ruz, M A
Jiménez-Aguilar, P
Marquez, M
Collado, A
Gomez-Vidal, A
Hernandez-Quero, J
Tellez, F
Fernandez-Fuertes, E
Rivero, A
López-Cortés, L F
Filiación: [Rivero-Juarez,A; Rivero,A] Unidad Clínica de Enfermedades Infecciosas, Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Universidad de Córdoba, Hospital Universitario Reina Sofía, Cordoba, Spain.[Gutierrez-Valencia,A; López-Cortés,LF] Unidad Clínica de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain. [Castaño,M] Unidad Clínica de Enfermedades Infecciosas, Hospital Regional Universitario Carlos Haya, Málaga, Spain.[Merino,D] Unidad Clínica de Enfermedades Infecciosas, Complejo Hospitalario Universitario de Huelva, Huelva, Spain.[Neukam,K] Unidad Clínica de Enfermedades Infecciosas y Microbiología, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario de Valme, Seville, Spain. [Rios-Villegas,JM] Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario Virgen Macarena, Seville, Spain. [Lopez-Ruz,MA] Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario Virgen de las Nieves, Granada, Spain. [Jimenez-Aguilar,P] Unidad Clínica de Enfermedades Infecciosas, Hospital Universitario Puerto Real, Cádiz, Spain. [Marquez,M] Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Regional Universitario Virgen de la Victoria, Málaga, Spain. [Collado,A] Unidad Clínica de Enfermedades Infecciosas, Complejo Hospitalario Torrecárdenas, Almería, Spain.[Gomez-Vidal,A] Unidad Clínica de Enfermedades Infecciosas, Complejo Hospitalario de Jaén, Jaén, Spain. [Hernandez-Quero,J] Unidad Clínica de Enfermedades Infecciosas, Hospital Universitario San Cecilio, Granada, Spain.[Tellez,F] Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital La Línea, AGS Campo de Gibraltad, Cádiz, Spain.[Fernandez-Fuertes,E] Unidad de Medicina Tropical, Hospital de Poniente, Almería, Spain.
Grupo de Investigación: Grupo para el Estudio de las Hepatitis Víricas (HEPAVIR) de la Sociedad Andaluza de Enfermedades Infecciosas (SAEI).
Palabras clave : Hepacivirus
Hepatopatías
Hepatitis C
VIH
Fallo Hepático
MeSH: Medical Subject Headings::Diseases::Digestive System Diseases::Liver Diseases
Medical Subject Headings::Diseases::Virus Diseases::Sexually Transmitted Diseases::Sexually Transmitted Diseases, Viral::HIV Infections
Medical Subject Headings::Diseases::Digestive System Diseases::Liver Diseases::Hepatic Insufficiency::Liver Failure
Medical Subject Headings::Diseases::Digestive System Diseases::Liver Diseases::Liver Cirrhosis
Fecha de publicación : 5-Sep-2015
Editorial : Springer
Cita Bibliográfica: Rivero-Juarez A, Gutierrez-Valencia A, Castaño M, Merino D, Neukam K, Ríos-Villegas MJ, et al. Dimension of chronic hepatitis C virus in HIV-infected patients in the interferon-free era: an overview from south Spain. Eur J Clin Microbiol Infect Dis. 2015; 34(11):2247-55
Abstract: The implementation of hepatitis C (HCV) direct-acting antiviral drugs is prioritized in several populations in which its application provides the most immediate and impactful benefit. In this scenario, a precise knowledge of the situation of human immunodeficiency virus (HIV)/HCV chronic co-infection is required to adequately address this disease. This cross-sectional study was performed in 21 hospitals in Andalusia (Spain). The study population consisted of HIV-infected patients with an active HCV chronic infection who were not receiving HCV treatment at the time of inclusion. A total of 13,506 HIV-infected patients were included in the study. Of them, 2561 (18.9 %) presented chronic HCV infection. The majority of the patients included were on highly active antiretroviral therapy (HAART; 96.2 %), showed plasma levels with an undetectable HIV viral load (92.5 %), and had a good immunological status (median CD4+ cell count of 486 cells/mL). The HCV genotype distribution was as follows: 58.1 % were genotype 1, 1.1 % were genotype 2, 16.1 % were genotype 3, and 22.1 % were genotype 4 (2.6 % were missing data). In total, 24.8 % of the patients showed liver fibrosis stage F0-F1, 27.9 % showed stage F2, 16.7 % showed stage F3, and 21 % showed stage F4 (9.6 % were missing data). With regards to previous HCV treatment experiences, 68.05 % of the patients were naïve and 31.95 % had failed to respond to a previous treatment. The burden of HCV/HIV co-infected patients in our population was reported as one in five HIV-infected patients requiring HCV treatment. The implementation of extra resources to face this important health challenge is mandatory.
Descripción : Journal Article;
URI: http://hdl.handle.net/10668/2347
Versión del editor : http://link.springer.com/article/10.1007%2Fs10096-015-2476-9
DOI: 10.1007/s10096-015-2476-9
ISSN : 1435-4373 (Online)
Appears in Collections:01- Artículos - AGS Sur de Sevilla
01- Artículos - Complejo Hospitalario Universitario de Granada
01- Artículos - AGS Campo de Gibraltar
01- Artículos - Complejo Hospitalario de Jaén
01- Artículos - Complejo Hospitalario Torrecárdenas
01- Artículos - Hospital Virgen de la Victoria
01- Artículos - Hospital de Puerto Real
01- Artículos - Hospital Virgen Macarena
01- Artículos - Hospital Virgen del Rocío
01- Artículos - IBIS. Instituto de Biomedicina de Sevilla
01- Artículos - Hospital Reina Sofía
01- Artículos - IMIBIC. Instituto Maimónides de Investigación Biomédica de Córdoba
01- Artículos - APES Hospital de Poniente
01- Artículos - Complejo Hospitalario Universitario de Huelva
01- Artículos - Hospital Regional de Málaga

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