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http://hdl.handle.net/10668/2364| Title: | In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. |
| Authors: | Briales, A Rodríguez-Martínez, J M Velasco, C Díaz de Alba, P Domínguez-Herrera, J Pachón, J Pascual, A |
| metadata.dc.contributor.authoraffiliation: | [Briales,A; Rodríguez-MartínezJM; Velasco,C; Díaz de Alba,P; Pascual,A] Department of Microbiology, University of Seville, Seville, Spain. [Domínguez-Herrera,J; Pachón,J] Infectious Diseases Service, Biomedicine Institute of Seville (IBiS), University Hospitals Virgen del Rocío/CSIC/University of Seville, Seville, Spain. [Pascual,A] University Hospital Virgen Macarena, Seville, Spain. |
| Keywords: | Pruebas de sensibilidad microbiana;Mutación;Ciprofloxacino |
| metadata.dc.subject.mesh: | Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Isomerases::DNA Topoisomerases::DNA Topoisomerases, Type II::DNA Gyrase Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Isomerases::DNA Topoisomerases::DNA Topoisomerases, Type II::DNA Topoisomerase IV Medical Subject Headings::Organisms::Bacteria::Gram-Negative Bacteria::Gram-Negative Facultatively Anaerobic Rods::Enterobacteriaceae::Escherichia::Escherichia coli Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Bacterial Proteins::Escherichia coli Proteins Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Quinolines::Quinolones::Fluoroquinolones Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Microbiological Techniques::Microbial Sensitivity Tests Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Quinolines::Quinolones::Fluoroquinolones::Ciprofloxacin |
| Issue Date: | Mar-2011 |
| Publisher: | American Society for Microbiology |
| Citation: | Briales A, Rodríguez-Martínez JM, Velasco C, Díaz de Alba P, Domínguez-Herrera J, Pachón J, et al. In vitro effect of qnrA1, qnrB1, and qnrS1 genes on fluoroquinolone activity against isogenic Escherichia coli isolates with mutations in gyrA and parC. Antimicrob. Agents Chemother. 2011; 55(3):1266-9 |
| Abstract: | This article provides an analysis of the in vitro effect of qnrA1, qnrB1, and qnrS1 genes, combined with quinolone-resistant Ser83Leu substitutions in GyrA and/or Ser80Arg in ParC, on fluoroquinolone (FQ) resistance in isogenic Escherichia coli strains. The association of Ser83Leu substitution in GyrA, Ser80Arg substitution in ParC, and qnr gene expression increased the MIC of ciprofloxacin to 2 μg/ml. qnr genes present in E. coli that harbored a Ser83Leu substitution in GyrA increased mutant prevention concentration (MPC) values to 8 to 32 μg/ml. qnr gene expression in E. coli may play an important role in selecting for one-step FQ-resistant mutants. |
| Description: | Journal Article; Research Support, Non-U.S. Gov't; |
| URI: | http://hdl.handle.net/10668/2364 |
| metadata.dc.relation.publisherversion: | http://aac.asm.org/content/55/3/1266.abstract |
| metadata.dc.identifier.doi: | 10.1128/AAC.00927-10 |
| ISSN: | 1098-6596 (Online) 0066-4804 (Print) |
| Appears in Collections: | 01- Artículos - Hospital Virgen del Rocío 01- Artículos - Hospital Virgen Macarena 01- Artículos - IBIS. Instituto de Biomedicina de Sevilla |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Briales_InVitroEffectqnrA1.pdf | Artículo publicado | 184,47 kB | Adobe PDF | View/Open |
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