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Title: The latin American dili registry experience: A successful ongoing collaborative strategic initiative.
Authors: Bessone, Fernando
Hernandez, Nelia
Lucena, M Isabel
Andrade, Raúl J
metadata.dc.contributor.authoraffiliation: [Bessone,F] Hospital Provincial del Centenario, University of Rosario School of Medicine, Rosario, Argentina. [Hernández,N] Hospital de Clínicas, Facultad de Medicina, UdelaR, Montevideo, Uruguay. [Lucena,MI; Andrade,R] Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Virgen de la Victoria, Universidad de Málaga, CIBERehd, Málaga, Spain. Latin Dili Network Latindilin
Spanish Dili Registry
Keywords: Hepatotoxicity;Drug-induced liver injury;Herbals and dietary supplements;Registry;Spanish DILI registry;Latin-American DILI registry;Enfermedad hepática inducida por drogas;Sistema de registros;Grupos étnicos;Fenotipo;Biomarcadores;Humanos;Latinoamérica;Mercadeo
metadata.dc.subject.mesh: Medical Subject Headings::Diseases::Digestive System Diseases::Liver Diseases::Drug-Induced Liver Injury
Medical Subject Headings::Health Care::Health Services Administration::Organization and Administration::Records as Topic::Registries
Medical Subject Headings::Health Care::Population Characteristics::Demography::Ethnic Groups
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Phenotype
Medical Subject Headings::Chemicals and Drugs::Biological Factors::Biological Markers
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Geographicals::Geographic Locations::Americas::Latin America
Medical Subject Headings::Geographicals::Geographic Locations::Americas::North America::United States
Medical Subject Headings::Technology, Industry, Agriculture::Technology, Industry, and Agriculture::Commerce::Marketing
Issue Date: 29-Feb-2016
Publisher: MDPI
Citation: Bessone F, Hernández N, Lucena MI, Andrade RJ. The latin American dili registry experience: A successful ongoing collaborative strategic initiative. Int J Mol Sci. 2016;17(3):E313
Abstract: Drug induced liver injury (DILI) is a rare but well recognized serious adverse reaction. Pre-marketing studies may not detect liver injury, and DILI becomes very often apparent after the drug is launched to the market. Specific biomarkers for DILI prediction or diagnosis are not available. Toxic liver reactions present with a wide spectrum of phenotypes and severity, and our knowledge on the mechanisms underlying idiosyncratic reactions and individual susceptibility is still limited. To overcome these limitations, country-based registries and multicenter research networks have been created in Europe and North America. Reliable epidemiological data on DILI in Latin America (LA), a region with a large variety of ethnic groups, were however lacking. Fortunately, a LA network of DILI was set up in 2011, with the support of the Spanish DILI Registry from the University of Malaga. The primary aim of the Latin DILI Network (LATINDILIN) Registry was to prospectively identify bona fide DILI cases and to collect biological samples to study genetic biomarkers. Physicians involved in the project must complete a structured report form describing the DILI case presentation and follow-up which is submitted to a Coordinator Center in each country, where it is further assessed for completeness. During the last four years, several LA countries (Argentina, Uruguay, Chile, Mexico, Paraguay, Brazil, Ecuador, Peru, Venezuela and Colombia) have joined the network and committed with this project. At that point, to identify both our strengths and weaknesses was a very important issue. In this review, we will describe how the LATINDILI Registry was created. The aims and methods to achieve these objectives will be discussed in depth. Additionally, both the difficulties we have faced and the strategies to solve them will be also pinpointed. Finally, we will report on our preliminary results, and discuss ideas to expand and to keep running this network.
Description: Journal Article; Review;
metadata.dc.identifier.doi: 10.3390/ijms17030313
ISSN: 1661-6596 (Print)
1422-0067 (Online)
Appears in Collections:01- Artículos - Hospital Virgen de la Victoria
01- Artículos - IBIMA. Instituto de Investigación Biomédica de Málaga

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