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Título : Nonsynonymous FCER1B SNP is Associated with Risk of Developing Allergic Rhinitis and with IgE Levels.
Autor : Amo, Gemma
García-Menaya, Jesús
Campo, Paloma
Cordobés, Concepción
Plaza Serón, M Carmen
Ayuso, Pedro
Esguevillas, Gara
Blanca, Miguel
Agúndez, Jose A G
García-Martín, Elena
Filiación: [Amo,G; Plaza Serón,MC; Agúndez,JAG; García-Martín,E] Department of Pharmacology, Universidad de Extremadura, Cáceres, Spain. [García-Menaya,J; Cordobés,C] Allergy Service, University Hospital Infanta Cristina, Badajoz, Spain. [Campo,P; Plaza Serón,MC; Blanca,M] Allergy Service, Hospital Carlos Haya, Málaga, Spain. [Ayuso,P] Research Laboratory, IBIMA Málaga University General Hospital, Málaga, Spain.
Palabras clave : Alelos
Inmunoglobulina E
Polimorfismo de nucleótido único
Receptores de IgE
Rinitis alérgica
MeSH: Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Alleles
Medical Subject Headings::Diseases::Respiratory Tract Diseases::Bronchial Diseases::Asthma
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Globulins::Serum Globulins::Immunoglobulins::Antibodies::Immunoglobulin Isotypes::Immunoglobulin E
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic::Polymorphism, Single Nucleotide
Medical Subject Headings::Chemicals and Drugs::Biological Factors::Biological Markers::Antigens, Differentiation::Antigens, CD::Receptors, IgE
Medical Subject Headings::Diseases::Respiratory Tract Diseases::Nose Diseases::Rhinitis::Rhinitis, Allergic
Fecha de publicación : 21-Jan-2016
Editorial : Nature Publishing Group
Cita Bibliográfica: Amo G, García-Menaya J, Campo P, Cordobés C, Plaza Serón MC, Ayuso P, et al. A Nonsynonymous FCER1B SNP is Associated with Risk of Developing Allergic Rhinitis and with IgE Levels. Sci Rep. 2016; 6:19724
Abstract: Allergic rhinitis is associated with elevated serum IgE levels. IgE response is mediated by the high-affinity IgE receptor (FcεRI), which is polymorphic. Studies analyzing the association between allergic rhinitis and FcεRI variants have been conducted with controversial results. The objective of this study is to analyze, in 1,041 individuals, the putative clinical association of allergic rhinitis with common polymorphisms in FcεRI subunits genes. These SNPs included FECR1A rs2494262, rs2427837 and rs2251746; FECR1B rs1441586, rs569108 and rs512555; FCER1G rs11587213, rs2070901 and rs11421. Statistically significant differences were observed for the FCER1B rs569108 and rs512555 polymorphisms frequencies when comparing patients with allergic rhinitis without asthma and controls. The OR (95% CI) value for the 237Gly allele (rs569108) is equal to 0.26 (0.08-0.86, P = 0.017) and for the G allele (rs512555) it is equal to 0.27 (0.08-0.88, P = 0.020). These two SNPs are linked (D' = 1.0, LOD = 56.05). Also observed was a statistically significant trend towards lower IgE values among allergic rhinitis patients with variant alleles for both SNPs. In conclusion, in patients with allergic rhinitis without asthma, the FCER1B rs569108 and rs512555 polymorphisms are associated with increased risk of developing allergic rhinitis and with lower IgE levels.
Descripción : Journal Article; Research Support, Non-U.S. Gov't;
Versión del editor :
DOI: 10.1038/srep19724
ISSN : 2045-2322 (Online)
Appears in Collections:01- Artículos - IBIMA. Instituto de Investigación Biomédica de Málaga
01- Artículos - Hospital Regional de Málaga

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