| Title: | An ex vivo native environment precision medicine test shows high clinical correlation with responses to first line acute myeloid leukemia treatment |
| Authors: | Montesinos, P
Ballesteros, J
Martinez Cuadron, D
Martinez Lopez, J
Serrano, J
Perez de Oteyza, J
Fernandez, P
Rodriguez Macias, G
Vidriales, B
Herrera, P
Tormo, M
Bergua, J
Garcia, R
Vives, S
Fernandez, MA
Lavilla, E
Jimenez, S
Perez Simon, JA
Simiele, A
Gonzalez, A
Gonzalez, B
Burgaleta, C
Lopez, JA
Bethancourt, C
Bautista, G
Alonso, A
Colorado, M
Sierra, J
Navas, B
Hernandez Rivas, JA
Vera, JA
Amador, L
Cordoba, R
de la Fuente, A
Ramos, F
Cervero, CJ
Rayon, C
Salamero, O
Marti, E
Loez, A
Olave, T
Gaspar, M
Gorrochategui, J
Rojas, JL
Gomez, C
Hernandez, P
Robles, A
Ortega, I
Villoria, J
Moscardo, F
Troconiz, I
Sanz, MA |
| metadata.dc.contributor.authoraffiliation: | [Montesinos,P; Martinez Cuadron,D; Moscardo,F; Sanz,MA] Hospital Universitari i Politecnic La Fe, Valencia. [Ballesteros,J; Gaspar,G; Gorrochategui,J; Rojas, JL; Gomez,C; Hernandez,P; Robles,A] Vivia Biotech, Tres Cantos. [Martinez Lopez, J] Hospital Universitario 12 de Octubre, Madrid. [Serrano,J] Hospital Universitario Reina Sofia, Cordoba. [Perez de Oteyza,J] Hospital Universitario San Chinarro, Madrid. [Fernandez,P] Hospital General Universitario de Alicante, Alicante. [Rodriguez Macias,G] Hospital Gregorio Marañon, Madrid. [Vidriales,B] Hospital Clinico Universitario de Salamanca, Salamanca. [Herrera,P] Hospital Universitario Ramon y Cajal, Madrid. [Tormo,M] Hospital Clinico Universitario de Valencia, Valencia.[Bergua,J ]Hospital San Pedro de Alcantara, Caceres. [Garcia,R] Hospital Universitario de Castellon, Castellon. [Vives,S] Hospital Universitari Germans Trias i Pujol, Badalona. [Fernandez,MA] Hopsital Xeral Cies, Vigo. [Lavilla,E] Hospital Lucus Augusti, Lugo. [Jimenez,S] Hospital Universitario de Gran Canaria Doctor Negrin, Las Palmas de Gran Canaria. [Perez Simon,JA] Hospital Universitario Virgen del Rocio, Sevilla. [Simiele,A] Hospital Povisa, Vigo. [Gonzalez,A] Hospital Universitario Clinico San Carlos, Madrid. [Gonzalez,B] Hospital Universitario de Canarias, La Laguna. [Burgaleta,C] Hospital Universitario Principe de Asturias, Alcala de Henares. [Lopez, JA] Complejo Hospitalario de Jaen, Jaen. [Bethancourt,C] Hospital Carlos Haya, Malaga. [Bautista,G] Hospital Universitario Puerta de Hierro, Majadahonda. [Alonso,A] Hospital Quiron, Madrid. [Colorado,M] Hospital Universitario Marques de Valdecilla, Santander. [Sierra,J] Hospital de la Santa Creu i Sant Pau, Barcelona. [Navas,B] Hospital Moncloa. [Hernandez Rivas, JA] Hospital Infanta Leonor, Madrid. [Vera,JA] Hospital Universitario Virgen Macarena, Sevilla. [Amador,L] Hospital Montecelo, Pontevedra. [Cordoba,R] Hospital Fundacion JImenez Diaz. [de la Fuente,A] MD Anderson Medical Center, Madrid. [Ramos,F] Hospital Universitario de Leon, Leon. [Cervero,CJ] Hospital Virgen de la Luz, Cuenca. [Rayon,C] Hospital Universitario Central de Asturias, Oviedo. [Salamero,O] Hospital Universitari Vall d’Hebron, Barcelona. [Marti,E] Hospital de Manises, Manises. [Loez,A] Hospital Arnau de Vilanova, Valencia. [Olave,T] Hospital Clinico Universitario LOzano Blesa, Zaragoza. [Ortega,I] Universidad del Pais Vasco, Bilbao. [Villoria,J] Medicxact, Madrid.
[Troconiz,I] Universidad de Navarra, Pamplona, Spain. |
| Keywords: | Adulto;Médula ósea;Citarabina;Ambiente;Humanos;Idarrubicina;Quimioterapia de inducción;Mantenimiento |
| metadata.dc.subject.mesh: | Medical Subject Headings::Named Groups::Persons::Age Groups::Adult
Medical Subject Headings::Anatomy::Hemic and Immune Systems::Immune System::Bone Marrow
Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleosides::Pyrimidine Nucleosides::Cytidine
Medical Subject Headings::Phenomena and Processes::Biological Phenomena::Ecological and Environmental Phenomena::Environment
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons, Cyclic::Hydrocarbons, Aromatic::Polycyclic Hydrocarbons, Aromatic::Naphthacenes::Anthracyclines::Daunorubicin::Idarubicin
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Induction Chemotherapy
Medical Subject Headings::Health Care::Health Care Facilities, Manpower, and Services::Maintenance
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Remission Induction |
| Issue Date: | Jun-2016 |
| Publisher: | Ferrata Storti Foundation |
| Citation: | Montesinos P, Ballesteros J, Martinez Cuadron D. Martinez Lopez J, Serrano J, Perez de Oteyza J et al. An ex vivo native environment precision medicine test shows high clinical correlation with responses to first line acute myeloid leukemia treatment. Haematologica. 2016; 101 (s1) P569 |
| Abstract: | This novel test is able to predict the clinical response to Ida+Ara-C induction with overall correlation and predictive values of 80%, higher than ever achieved. Considering this result and current clinical response
rate of 66.7% (70% in this study), clear clinical benefits can be achieved with
the use of the test. Adding the cytogenetic risk profile further increase the correlation
to 90%. Thus this novel test may be valuable information to guide 1st line patient therapy |
| URI: | http://hdl.handle.net/10668/2442 |
| metadata.dc.relation.publisherversion: | http://www.haematologica.org/content/101/s1 |
| ISSN: | 0390-6078 (Print)
1592-8721 (Online) |
| Appears in Collections: | 01- Artículos - Complejo Hospitalario de Jaén
01- Artículos - Hospital Regional de Málaga
01- Artículos - Hospital Reina Sofía
01- Artículos - Hospital Virgen del Rocío
01- Artículos - Hospital Virgen Macarena
|
