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Title: Blood lipid and lipoprotein concentrations and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition
Authors: van Duijnhoven, Fränzel J B
Bueno-De-Mesquita, H Bas
Calligaro, Miriam
Jenab, Mazda
Pischon, Tobias
Jansen, Eugène H J M
Frohlich, Jiri
Ayyobi, Amir
Overvad, Kim
Toft-Petersen, Anne Pernille
Tjønneland, Anne
Hansen, Louise
Boutron-Ruault, Marie-Christine
Clavel-Chapelon, Françoise
Cottet, Vanessa
Palli, Domenico
Tagliabue, Giovanna
Panico, Salvatore
Tumino, Rosario
Vineis, Paolo
Kaaks, Rudolf
Teucher, Birgit
Boeing, Heiner
Drogan, Dagmar
Trichopoulou, Antonia
Lagiou, Pagona
Dilis, Vardis
Peeters, Petra H M
Siersema, Peter D
Rodríguez, Laudina
González, Carlos A
Molina-Montes, Esther
Dorronsoro, Miren
Tormo, Maria-Jose
Barricarte, Aurelio
Palmqvist, Richard
Hallmans, Göran
Khaw, Kay-Tee
Tsilidis, Kostas K
Crowe, Francesca L
Chajes, Veronique
Fedirko, Veronika
Rinaldi, Sabina
Norat, Teresa
Riboli, Elio
metadata.dc.contributor.authoraffiliation: [van Duijnhoven,FJB; Bueno-De-Mesquita,HB; Calligaro,M; Jansen,EHJM] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands. [van Duijnhoven,FJB] Univ Med Ctr, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands. [Bueno-De-Mesquita,HB; Siersema,PD] Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands. [Jenab,M; Chajes,V; Fedirko,V; Rinaldi,S] Int Agcy Res Canc IARC WHO, Lyon, France. [Pischon,T; Boeing,H; Drogan,D] German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, Nuthetal, Germany. [Frohlich,J; Ayyobi,A] Univ British Columbia, St Pauls Hosp, Vancouver, Canada. [Overvad,K] Aarhus Univ, Sch Publ Hlth, Dept Epidemiol, Aarhus, Denmark. [Overvad,K; Toft-Petersen,AP] Aarhus Univ Hosp, Aalborg Hosp, Dept Cardiol, Aalborg, Denmark. [Tjonneland,A; Hansen,L] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark. [Boutron-Ruault,MC; Clavel-Chapelon,F; Cottet,V] INSERM, UMRS 1018, Team 9, Centre for Research in Epidemiology and Population Health, Paris S Univ, Inst Gustave Roussy, Ctr Res Epidemiol & Populat Hlth, Villejuif, France. [Palli,D] ISPO Canc Res & Prevent Inst, Mol & Nutr Epidemiol Unit, Florence, Italy. [Tagliabue, G] Fdn IRCCS Inst Nazl Tumori, Environm Epidemiol Unit, Milan, Italy. [Tagliabue, G] Fdn IRCCS Inst Nazl Tumori, Canc Registry, Milan, Italy. [Panico, S] Univ Naples Federico 2, Dept Clin & Expt Med, Naples, Italy. [Tumino,R] Civile MP Arezzo Hosp, Dept Oncol, Histopathol Unit, Ragusa, Italy. [Tumino, R] Civile MP Arezzo Hosp, Canc Registry, Ragusa, Italy. [Vineis, P] HuGeF Fdn Torino, Turin, Italy. [Vineis, P] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, MRC HPA Ctr Environm & Hlth, London, England. [Kaaks, R;Teucher, B] German Canc Res Ctr, Div Canc Epidemiol, D-6900 Heidelberg, Germany. [Trichopoulou, A;Lagiou, P] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, WHO Collaborating Ctr Food & Nutr Policies, GR-11527 Athens, Greece. [Trichopoulou,A; Dilis,V] Hellen Hlth Fdn, Athens, Greece. [Peeters,PHM; Norat,T; Riboli,E] Univ London Imperial Coll Sci Technol & Med, Div Epidemiol Publ Hlth & Primary Care, London, England. [Rodriguez,L] Hlth & Hlth Care Serv Council, Publ Hlth & Participat Directorate, Asturias, Spain. [Gonzalez,CA] Catalan Inst Oncol, Unit Nutr Environm & Canc, Barcelona, Spain. [Molina-Montes,E] Andalusia Sch Publ Hlth, Granada, Spain. [Dorronsoro,M] Dept Publ Hlth Guipuzkoa, San Sebastian, Spain. [Tormo,MJ] Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain. [Barricarte,A] Publ Hlth Inst Navarra, Pamplona, Spain. [Palmqvist,R] Umea Univ, Dept Med Biosci, Umea, Sweden. [Hallmans,G] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden. [Khaw,KT] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge CB2 1TN, England. [Tsilidis,KK; Crowe,FL] Univ Oxford, Nuffield Dept Clin Med, Canc Epidemiol Unit, Oxford, England.
Keywords: Lipids;Lípidos;Colorectal neoplasms;Cáncer colorrectal;Nutrition Surveys;Encuestas nutricionales
metadata.dc.subject.mesh: Medical Subject Headings::Chemicals and Drugs::Lipids::Lipoproteins
Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms
Medical Subject Headings::Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Data Collection::Nutrition Assessment::Nutrition Surveys
Medical Subject Headings::Geographical Locations::Geographic Locations::Europe
Issue Date: 7-Mar-2011
Publisher: British Society of Gastroenterology
Citation: van Duijnhoven FJ, Bueno-De-Mesquita HB, Calligaro M, Jenab M, Pischon T, Jansen EH, Frohlich J, et al. Blood lipid and lipoprotein concentrations and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition. Gut. 2011 Aug;60(8):1094-102
Abstract: Objective To examine the association between serum concentrations of total cholesterol, high density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol, triglycerides, apolipoprotein A-I (apoA), apolipoprotein B and the incidence of colorectal cancer (CRC). Design Nested case–control study. Setting The study was conducted within the European Prospective Investigation into Cancer and Nutrition (EPIC), a cohort of more than 520 000 participants from 10 western European countries. Participants 1238 cases of incident CRC, which developed after enrolment into the cohort, were matched with 1238 controls for age, sex, centre, follow-up time, time of blood collection and fasting status. Main outcome measures Serum concentrations were quantitatively determined by colorimetric and turbidimetric methods. Dietary and lifestyle data were obtained from questionnaires. Conditional logistic regression models were used to estimate incidence rate ratios (RRs) and 95% CIs which were adjusted for height, weight, smoking habits, physical activity, education, consumption of fruit, vegetables, meat, fish, alcohol, fibre and energy. Results After adjustments, the concentrations of HDL and apoA were inversely associated with the risk of colon cancer (RR for 1 SD increase of 16.6 mg/dl in HDL and 32.0 mg/dl in apoA of 0.78 (95% CI 0.68 to 0.89) and 0.82 (95% CI 0.72 to 0.94), respectively). No association was observed with the risk of rectal cancer. Additional adjustment for biomarkers of systemic inflammation, insulin resistance and oxidative stress or exclusion of the first 2 years of follow-up did not influence the association between HDL and risk of colon cancer. Conclusions These findings show that high concentrations of serum HDL are associated with a decreased risk of colon cancer. The mechanism behind this association needs further elucidation.
metadata.dc.identifier.doi: 10.1136/gut.2010.225011
ISSN: 0017-5749 (Print)
1468-3288 (Online)
Appears in Collections:01- Artículos - EASP. Escuela Andaluza de Salud Pública

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