Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/2474
Title: Influence of elevated-CRP level-related polymorphisms in non-rheumatic Caucasians on the risk of subclinical atherosclerosis and cardiovascular disease in rheumatoid arthritis.
Authors: López-Mejías, Raquel
Genre, Fernanda
Remuzgo-Martínez, Sara
González-Juanatey, Carlos
Robustillo-Villarino, Montserrat
Llorca, Javier
Corrales, Alfonso
Vicente, Esther
Miranda-Filloy, José A
Magro, César
Tejera-Segura, Beatriz
Ramírez Huaranga, Marco A
Pina, Trinitario
Blanco, Ricardo
Alegre-Sancho, Juan J
Raya, Enrique
Mijares, Verónica
Ubilla, Begoña
Mínguez Sánchez, María D
Gómez-Vaquero, Carmen
Balsa, Alejandro
Pascual-Salcedo, Dora
López-Longo, Francisco J
Carreira, Patricia
González-Álvaro, Isidoro
Rodríguez-Rodríguez, Luis
Fernández-Gutiérrez, Benjamín
Ferraz-Amaro, Iván
Castañeda, Santos
Martín, Javier
González-Gay, Miguel A
metadata.dc.contributor.authoraffiliation: [López-Mejías,R; Remuzgo-Martínez,S; Genre,F; Corrales,A; Pina,T; Blanco,R; Mijares,V; Ubilla,B; González-Gay,MA] Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Division of Rheumatology, IDIVAL, Santander, Spain. [González-Juanatey,C] Cardiology Department, Hospital Lucus Augusti, Lugo, Spain. [Robustillo-Villarino,M; Alegre-Sancho,JJ] Division of Rheumatology, Hospital Universitario Doctor Peset, Valencia, Spain. [Llorca,J] Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander, Spain. [Vicente,E; González-Álvaro,I; Castañeda,S] Division of Rheumatology, Hospital Universitario la Princesa, IIS-IPrincesa, Madrid, Spain. [Miranda-Filloy,JA] Rheumatology Department, Hospital Universitario Lucus Augusti, Lugo, Spain. [Magro,C; Raya,E] Division of Rheumatology, Hospital Clínico San Cecilio, Granada, Spain. [Tejera-Segura,B; Ferraz-Amaro,I] Rheumatology Division, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain. [Ramírez Huaranga,MA; Mínguez Sánchez,MD] Rheumatology Department, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain. [Gómez-Vaquero,C] Department of Rheumatology, Hospital Universitario Bellvitge, Barcelona, Spain. [Balsa,A; Pascual-Salcedo,D] Department of Rheumatology, Hospital Universitario La Paz, Madrid, Spain. [López-Longo,FJ] Department of Rheumatology, Hospital General Universitario Gregorio Marañón, Madrid, Spain. [Carreira,P] Department of Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain. [Rodríguez-Rodríguez,L; Fernández-Gutiérrez,B] Department of Rheumatology, Hospital Clínico San Carlos, Madrid, Spain. [Martín,J] Institute of Parasitology and Biomedicine López-Neyra, IPBLN-CSIC, Granada, Spain. [González-Gay,MA] School of Medicine, University of Cantabria, Santander, Spain. Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Keywords: Artritis reumatoide;Aterosclerosis;Proteína c-reactiva;Grosor intima-media carotídeo;Genotipo;Humanos;Polimorfismo genético
metadata.dc.subject.mesh: Medical Subject Headings::Diseases::Musculoskeletal Diseases::Rheumatic Diseases::Arthritis, Rheumatoid
Medical Subject Headings::Diseases::Cardiovascular Diseases::Vascular Diseases::Arterial Occlusive Diseases::Arteriosclerosis::Atherosclerosis
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Albumins::C-Reactive Protein
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Ultrasonography::Carotid Intima-Media Thickness
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic
Issue Date: 18-Aug-2016
Publisher: Nature Publishing Group
Citation: López-Mejías R, Genre F, Remuzgo-Martínez S, González-Juanatey C, Robustillo-Villarino M, Llorca J, et al. Influence of elevated-CRP level-related polymorphisms in non-rheumatic Caucasians on the risk of subclinical atherosclerosis and cardiovascular disease in rheumatoid arthritis. Sci Rep. 2016; 6:31979
Abstract: Association between elevated C-reactive protein (CRP) serum levels and subclinical atherosclerosis and cardiovascular (CV) events was described in rheumatoid arthritis (RA). CRP, HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A and SALL1 exert an influence on elevated CRP serum levels in non-rheumatic Caucasians. Consequently, we evaluated the potential role of these genes in the development of CV events and subclinical atherosclerosis in RA patients. Three tag CRP polymorphisms and HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A and SALL1 were genotyped in 2,313 Spanish patients by TaqMan. Subclinical atherosclerosis was determined in 1,298 of them by carotid ultrasonography (by assessment of carotid intima-media thickness-cIMT-and presence/absence of carotid plaques). CRP serum levels at diagnosis and at the time of carotid ultrasonography were measured in 1,662 and 1,193 patients, respectively, by immunoturbidimetry. Interestingly, a relationship between CRP and CRP serum levels at diagnosis and at the time of the carotid ultrasonography was disclosed. However, no statistically significant differences were found when CRP, HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A and SALL1 were evaluated according to the presence/absence of CV events, carotid plaques and cIMT after adjustment. Our results do not confirm an association between these genes and CV disease in RA.
Description: Journal Article;
URI: http://hdl.handle.net/10668/2474
metadata.dc.relation.publisherversion: http://www.nature.com/articles/srep31979
metadata.dc.identifier.doi: 10.1038/srep31979
ISSN: 2045-2322 (Online)
Appears in Collections:01- Artículos - Complejo Hospitalario Universitario de Granada

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