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http://hdl.handle.net/10668/2482| Title: | Relationship between Proinflammatory and Antioxidant Proteins with the Severity of Cardiovascular Disease in Type 2 Diabetes Mellitus. |
| Authors: | García-Fontana, Beatriz Morales-Santana, Sonia Longobardo, Victoria Reyes-García, Rebeca Rozas-Moreno, Pedro García-Salcedo, José Antonio Muñoz-Torres, Manuel |
| metadata.dc.contributor.authoraffiliation: | [García-Fontana,B; Morales-Santana,S; Reyes-García,R; Muñoz-Torres,M] Bone Metabolic Unit, Endocrinology Division (RETICEF), Instituto de Investigación Biosanitaria (Ibs) Granada, University Hospital San Cecilio, Granada, Spain. [Morales-Santana,S] Proteomic Research Service, Instituto de Investigación Biosanitaria (Ibs) Granada, University Hospital San Cecilio, Granada, Spain. [Longobardo,V] Proteomic Research Service, Institute of Parasitology and Biomedicine “López Neyra” (C.S.I.C.), Granada, Spain. [Rozas-Moreno,P] Endocrinology Division, Ciudad Real General Hospital, Ciudad Real, Spain. [García-Salcedo,JA] Infectious Diseases Unit, Instituto de Investigación Biosanitaria (Ibs) Granada, University Hospital San Cecilio, Granada, Spain. [Muñoz-Torres,M] Endocrinology Unit, University Hospital San Cecilio, Spain. |
| Keywords: | Cardiovascular disease;Type 2 diabetes mellitus;Proinflammation;Oxidative stress;Proteomic;Antioxidantes;Biomarcadores;Enfermedades cardiovasculares;Cromatografía liquida;Diabetes mellitus tipo 2;Humanos;Electroforesis bidimensional diferencial en gel;Estrés oxidativo;Proteómica;Espectrometría de masa por láser de matriz asistida de ionización desorción;Espectrometría de masas en tándem |
| metadata.dc.subject.mesh: | Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Anthropometry Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Antioxidants Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Chemistry Techniques, Analytical::Chromatography::Chromatography, Liquid Medical Subject Headings::Diseases::Cardiovascular Diseases Medical Subject Headings::Chemicals and Drugs::Biological Factors::Biomarkers Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cross-Sectional Studies Medical Subject Headings::Diseases::Endocrine System Diseases::Diabetes Mellitus::Diabetes Complications Medical Subject Headings::Diseases::Endocrine System Diseases::Diabetes Mellitus::Diabetes Mellitus, Type 2 Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Oxidoreductases::Peroxidases::Glutathione Peroxidase Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation Medical Subject Headings::Check Tags::Male Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Chemical Processes::Physicochemical Processes::Oxidation-Reduction Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Oxidative Stress Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis Medical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biochemistry::Proteomics Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Health Surveys::Health Status Indicators::Severity of Illness Index Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Chemistry Techniques, Analytical::Mass Spectrometry::Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Chemistry Techniques, Analytical::Mass Spectrometry::Tandem Mass Spectrometry Medical Subject Headings::Named Groups::Persons::Age Groups::Adult Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Chemistry Techniques, Analytical::Electrophoresis::Electrophoresis, Gel, Two-Dimensional::Two-Dimensional Difference Gel Electrophoresis |
| Issue Date: | 27-Apr-2015 |
| Publisher: | MDPI |
| Citation: | García-Fontana B, Morales-Santana S, Longobardo V, Reyes-García R, Rozas-Moreno P, García-Salcedo JA, et al. Relationship between Proinflammatory and Antioxidant Proteins with the Severity of Cardiovascular Disease in Type 2 Diabetes Mellitus. Int J Mol Sci. 2015; 16(5):9469-83 |
| Abstract: | Type 2 diabetes mellitus patients are at significant risk of cardiovascular disease, however, the pathophysiology of these complications is complex and incompletely known in this population. The aim of this study was to compare the serum proteome of patients with type 2 diabetes mellitus presenting or not presenting cardiovascular disease with non-diabetic subjects to find essential proteins related to these cardiovascular complications. This cross-sectional study compares the serum proteome by a combination of protein depletion with 2D-DIGE (2-dimension Difference Gel Electrophoresis) methodology. The proteins differentially expressed were identified by MALDI TOF/TOF (Matrix-assisted laser desorption/ionization and Time-Of-Flight ion detector) or LC-MS/MS (Liquid Chromatography coupled to Mass-Mass Spectrometry). Type 2 diabetes mellitus patients with cardiovascular disease showed higher expression of plasma retinol binding protein and glutathione peroxidase-3 compared to those without cardiovascular disease and non-diabetic controls. These results show that proteins related to the inflammatory and redox state appear to play an important role in the pathogenesis of the cardiovascular disease in the type 2 diabetes mellitus patients. |
| Description: | Journal Article; Research Support, Non-U.S. Gov't; |
| URI: | http://hdl.handle.net/10668/2482 |
| metadata.dc.relation.publisherversion: | http://www.mdpi.com/1422-0067/16/5/9469 |
| metadata.dc.identifier.doi: | 10.3390/ijms16059469 |
| ISSN: | 1422-0067 (Online) |
| Appears in Collections: | 01- Artículos - Complejo Hospitalario Universitario de Granada 01- Artículos - ibsGRANADA. Instituto de Investigación Biosanitaria de Granada |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| GarciaFontana_RelationshipBetweenProinflammatory.pdf | Artículo publicado | 1,1 MB | Adobe PDF | View/Open |
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