Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/2504
Título : Impact of universal access to hepatitis C therapy on HIV-infected patients: implementation of the Spanish national hepatitis C strategy.
Autor : Rivero-Juarez, A
Lopez-Cortes, L F
Castaño, M
Merino, D
Marquez, M
Mancebo, M
Cuenca-Lopez, F
Jimenez-Aguilar, P
Lopez-Montesinos, I
Lopez-Cardenas, S
Collado, A
Lopez-Ruz, M A
Omar, M
Tellez, F
Perez-Stachowski, X
Hernandez-Quero, J
Girón-Gonzalez, J A
Fernandez-Fuertes, E
Rivero, A
Filiación: [Rivero-Juarez,A; Cuenca-Lopez,F; Rivero,A] Unidad de Enfermedades Infecciosas, Hospital Universitario Reina Sofía de Córdoba, Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Universidad de Córdoba (UCO), Córdoba, Spain. [Lopez-Cortes,LF] Unidad Clínica de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain. [Castaño,M] Unidad Clínica de Enfermedades Infecciosas, Hospital Regional Universitario Carlos Haya, Málaga, Spain. [Merino,D] Unidad Clínica de Enfermedades Infecciosas, Complejo Hospitalario Universitario de Huelva, Huelva, Spain. [Marquez,M] Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Regional Universitario Virgen de la Victoria, Málaga, Spain. [Mancebo,M] Unidad Clínica de Enfermedades Infecciosas y Microbiología, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario de Valme, Seville, Spain. [Jimenez-Aguilar,P] Unidad Clínica de Enfermedades Infecciosas, Hospital Universitario Puerto Real, Cádiz, Spain. [Lopez-Montesinos,I] Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario Virgen Macarena, Seville, Spain. [Lopez-Cardenas,S] Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital de Jerez, Jerez, Spain. [Collado,A] Unidad Clínica de Enfermedades Infecciosas, Complejo Hospitalario Torrecárdenas, Almería, Spain. [Lopez-Ruz,MA] Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario Virgen de las Nieves, Granada, Spain. [Omar,M] Unidad Clínica de Enfermedades Infecciosas, Complejo Hospitalario de Jaén, Jaén, Spain. [Tellez,F] Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital La Línea, AGS Campo de Gibraltad, Cádiz, Spain. [Perez-Stachowski,X] Unidad de Medicina Interna, Hospital Costa del Sol, Marbella, Spain. [Hernandez-Quero,J] Unidad Clínica de Enfermedades Infecciosas, Hospital Universitario San Cecilio, Granada, Spain. [Girón-Gonzalez,JA] Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Puerta del Mar, Cádiz, Spain. [Fernandez-Fuertes,A] Unidad de Medicina Tropical, Hospital de Poniente, El Ejido, Spain.
Grupo de Investigación: HERACLES cohort study team of the Grupo de Estudio de Hepatitis Virales (HEPAVIR) of the Sociedad Andaluza de Enfermedades Infecciosas (SAEI)
Palabras clave : Coinfección
Intervalos de confianza
Estudios de seguimiento
Infecciones por VIH
Hepatitis c crónica
Humanos
Incidencia
Interferones
Cirrosis hepática
España
MeSH: Medical Subject Headings::Diseases::Bacterial Infections and Mycoses::Infection::Coinfection
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Confidence Intervals
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Follow-Up Studies
Medical Subject Headings::Diseases::Virus Diseases::RNA Virus Infections::Retroviridae Infections::Lentivirus Infections::HIV Infections
Medical Subject Headings::Organisms::Viruses::Hepatitis Viruses::Hepacivirus
Medical Subject Headings::Diseases::Virus Diseases::Hepatitis, Viral, Human::Hepatitis C
Medical Subject Headings::Diseases::Virus Diseases::Hepatitis, Viral, Human::Hepatitis C::Hepatitis C, Chronic
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Incidence
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Interferons
Medical Subject Headings::Diseases::Digestive System Diseases::Liver Diseases::Liver Cirrhosis
Medical Subject Headings::Geographicals::Geographic Locations::Europe::Spain
Fecha de publicación : 27-Oct-2016
Editorial : Springer Verlag
Cita Bibliográfica: Rivero-Juarez A, Lopez-Cortes LF, Castaño M, Merino MD, Marquez M, et al. Impact of universal access to hepatitis C therapy on HIV-infected patients: implementation of the Spanish national hepatitis C strategy. Eur J Clin Microbiol Infect Dis. 2016, Oct 27
Abstract: In April 2015, the Spanish National Health System (SNHS) developed a national strategic plan for the diagnosis, treatment, and management of hepatitis C virus (HCV). Our aim was to analyze the impact of this on human immunodeficiency virus (HIV)-infected patients included in the HERACLES cohort during the first 6 months of its implementation. The HERACLES cohort (NCT02511496) was set up in March 2015 to evaluate the status and follow-up of chronic HCV infection in patients co-infected with HIV in the south of Spain. In September 2015, the data were analyzed to identify clinical events (death, liver decompensation, and liver fibrosis progression) and rate of treatment implementation in this population. The study population comprised a total of 3474 HIV/HCV co-infected patients. The distribution according to liver fibrosis stage was: 1152 F0-F1 (33.2 %); 513 F2 (14.4 %); 641 F3 (18.2 %); 761 F4 (21.9 %); and 407 whose liver fibrosis was not measured (12.3 %). During follow-up, 248 patients progressed by at least one fibrosis stage [7.1 %; 95 % confidence interval (CI): 6.3-8 %]. Among cirrhotic patients, 52 (6.8 %; 95 % CI: 5.2-8.9 %) developed hepatic decompensation. In the overall population, 50 patients died (1.4 %; 95 % CI: 1.1-1.9 %). Eight hundred and nineteen patients (23.56 %) initiated interferon (IFN)-free treatment during follow-up, of which 47.8 % were cirrhotic. In our study, during 6 months of follow-up, 23.56 % of HIV/HCV co-infected patients included in our cohort received HCV treatment. However, we observed a high incidence of negative short-term outcomes in our population.
Descripción : Journal Article; Ethical approval The study coordinator presented the study protocol (protocol code: FIBICO-0015/01017-2015) to the Coordinating Ethics Committee for Biomedical Research in Andalusia for evaluation and obtained approval (240-2819-05/15).
URI: http://hdl.handle.net/10668/2504
Versión del editor : http://link.springer.com/article/10.1007%2Fs10096-016-2822-6
DOI: 10.1007/s10096-016-2822-6
ISSN : 1435-4373 (Online)
0934-9723 (Print)
Appears in Collections:01- Artículos - APES Costa del Sol
01- Artículos - AGS Campo de Gibraltar
01- Artículos - Complejo Hospitalario de Jaén
01- Artículos - Complejo Hospitalario Torrecárdenas
01- Artículos - Hospital de Jerez
01- Artículos - Hospital Virgen Macarena
01- Artículos - APES Hospital de Poniente
01- Artículos - Hospital Puerta del Mar
01- Artículos - Hospital de Puerto Real
01- Artículos - AGS Sur de Sevilla
01- Artículos - Hospital Virgen de la Victoria
01- Artículos - Complejo Hospitalario Universitario de Huelva
01- Artículos - Hospital Regional de Málaga
01- Artículos - Hospital Virgen del Rocío
01- Artículos - IBIS. Instituto de Biomedicina de Sevilla
01- Artículos - IMIBIC. Instituto Maimónides de Investigación Biomédica de Córdoba
01- Artículos - Hospital Reina Sofía
01- Artículos - Complejo Hospitalario Universitario de Granada

Files in This Item:
File Description SizeFormat 
RiveroJuarez_ImpactOfUniversalAccess.pdfArtículo publicado433,93 kBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons