Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/2511
Título : FCERI and Histamine Metabolism Gene Variability in Selective Responders to NSAIDS.
Autor : Amo, Gemma
Cornejo-García, José A
García-Menaya, Jesus M
Cordobes, Concepcion
Torres, M J
Esguevillas, Gara
Mayorga, Cristobalina
Martinez, Carmen
Blanca-Lopez, Natalia
Canto, Gabriela
Ramos, Alfonso
Blanca, Miguel
Agúndez, José A G
García-Martín, Elena
Filiación: [Amo,G; Esguevillas,G; Martínez,C; Agúndez,JAG; García-Martín,E] Departamento de Farmacología, Universidad de Extremadura, Cáceres, Spain. [Cornejo,JA; Mayorga,C] Laboratorio de Investigación, Instituto de Investigación Biomédica de Málaga, Hospital Regional Universitario de Málaga, Universidad de Málaga, Málaga, Spain. [García-Menaya,JM; Cordobes,C] Servicio de Alergologia, Hospital Infanta Cristina, Badajoz, Spain. [Torres,MJ] UGC de Alergia, Instituto de Investigación Biomédica de Málaga, Hospital Regional Universitario de Málaga, Universidad de Málaga, Málaga, Spain. [Blanca-Lopez,N; Canto,G; Blanca,M] Servicio de Alergologia, Hospital Infanta Leonor, Madrid, Spain. [Ramos,A] Departamento de Matemáticas, Universidad de Extremadura, Cáceres, Spain.
Palabras clave : Fcε
RI
Histamine
Non-steroidal anti-inflammatory drugs (NSAIDS)
Hypersensitivity drug reactions
Biomarkers
Acetaminofén
Antiinflamatorios no Esteroideos
Aspirina
Diclofenaco
Dipirona
Ácido flufenámico
Marcadores genéticos
Histamina
Ibuprofeno
Inmunoglobulina E
Indometacina
Cetoprofeno
Modelos logísticos
Naproxeno
Oxifenilbutazona
Piroxicam
Polimorfismo de Nucleótido Simple
Piridinas
Receptores de IgE
Sulfonas
MeSH: Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amides::Anilides::Acetanilides::Acetaminophen
Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Peripheral Nervous System Agents::Sensory System Agents::Analgesics::Analgesics, Non-Narcotic::Anti-Inflammatory Agents, Non-Steroidal
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Carboxylic Acids::Acids, Carbocyclic::Benzoic Acids::Hydroxybenzoic Acids::Salicylic Acids::Aspirin
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Carboxylic Acids::Acids, Carbocyclic::Phenylacetates::Diclofenac
Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Azoles::Pyrazoles::Pyrazolones::Aminopyrine::Dipyrone
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Carboxylic Acids::Acids, Carbocyclic::Benzoic Acids::Aminobenzoic Acids::Anthranilic Acids::Fenamates::Flufenamic Acid
Medical Subject Headings::Chemicals and Drugs::Biological Factors::Biological Markers::Genetic Markers
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amines::Biogenic Amines::Biogenic Monoamines::Histamine
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Carboxylic Acids::Acids, Carbocyclic::Phenylpropionates::Ibuprofen
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Immunoglobulin Isotypes::Immunoglobulin E
Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Indoles::Indomethacin
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Carboxylic Acids::Acids, Carbocyclic::Phenylpropionates::Ketoprofen
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models, Statistical::Logistic Models
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons, Cyclic::Hydrocarbons, Aromatic::Polycyclic Hydrocarbons, Aromatic::Naphthalenes::Naphthaleneacetic Acids::Naproxen
Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Azoles::Pyrazoles::Pyrazolones::Phenylbutazone::Oxyphenbutazone
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Sulfur Compounds::Thiazines::Piroxicam
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic::Polymorphism, Single Nucleotide
Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Pyridines
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, Immunologic::Receptors, Fc::Receptors, IgE
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Sulfur Compounds
Fecha de publicación : 29-Sep-2016
Editorial : Frontiers Media
Cita Bibliográfica: Amo G, Cornejo-García JA, García-Menaya JM, Cordobes C, Torres MJ, Esguevillas G, et al. FCERI and Histamine Metabolism Gene Variability in Selective Responders to NSAIDS. Front Pharmacol. 2016; 7:353
Abstract: The high-affinity IgE receptor (Fcε RI) is a heterotetramer of three subunits: Fcε RIα, Fcε RIβ, and Fcε RIγ (αβγ2) encoded by three genes designated as FCER1A, FCER1B (MS4A2), and FCER1G, respectively. Recent evidence points to FCERI gene variability as a relevant factor in the risk of developing allergic diseases. Because Fcε RI plays a key role in the events downstream of the triggering factors in immunological response, we hypothesized that FCERI gene variants might be related with the risk of, or with the clinical response to, selective (IgE mediated) non-steroidal anti-inflammatory (NSAID) hypersensitivity. From a cohort of 314 patients suffering from selective hypersensitivity to metamizole, ibuprofen, diclofenac, paracetamol, acetylsalicylic acid (ASA), propifenazone, naproxen, ketoprofen, dexketoprofen, etofenamate, aceclofenac, etoricoxib, dexibuprofen, indomethacin, oxyphenylbutazone, or piroxicam, and 585 unrelated healthy controls that tolerated these NSAIDs, we analyzed the putative effects of the FCERI SNPs FCER1A rs2494262, rs2427837, and rs2251746; FCER1B rs1441586, rs569108, and rs512555; FCER1G rs11587213, rs2070901, and rs11421. Furthermore, in order to identify additional genetic markers which might be associated with the risk of developing selective NSAID hypersensitivity, or which may modify the putative association of FCERI gene variations with risk, we analyzed polymorphisms known to affect histamine synthesis or metabolism, such as rs17740607, rs2073440, rs1801105, rs2052129, rs10156191, rs1049742, and rs1049793 in the HDC, HNMT, and DAO genes. No major genetic associations with risk or with clinical presentation, and no gene-gene interactions, or gene-phenotype interactions (including age, gender, IgE concentration, antecedents of atopy, culprit drug, or clinical presentation) were identified in patients. However, logistic regression analyses indicated that the presence of antecedents of atopy and the DAO SNP rs2052129 (GG) were strongly related (P < 0.001 and P = 0.005, respectively) with selective hypersensitivity to ibuprofen. With regard to patients with selective hypersensitivity to ASA, men were more prone to develop such a reaction than women (P = 0.011), and the detrimental DAO SNP rs10156191 in homozygosity increased the risk of developing such hypersensitivity (P = 0.039).
Descripción : JOURNAL ARTICLE;
URI: http://hdl.handle.net/10668/2511
Versión del editor : http://journal.frontiersin.org/article/10.3389/fphar.2016.00353/full#h1
DOI: 10.3389/fphar.2016.00353
ISSN : 1663-9812 (Online)
Appears in Collections:01- Artículos - IBIMA. Instituto de Investigación Biomédica de Málaga
01- Artículos - Hospital Regional de Málaga

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