Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/2513
Título : No evidence of firstly acquired acute hepatitis C virus infection outbreak among HIV-infected patients from Southern Spain: a multicentric retrospective study from 2000-2014.
Autor : Neukam, Karin
Viciana, Pompeyo
Ojeda-Burgos, Guillermo
Delgado-Fernández, Marcial
Ríos, María J
Macías, Juan
Merino, Dolores
Collado, Antonio
Téllez, Francisco
Pineda, Juan A
Filiación: [Neukam,K; Macías,J; Pineda,JA] Unit of Infectious Diseases and Microbiology, Hospital Universitario de Valme, Seville, Spain. [Neukam,K; Viciana,P; Macías,J] Instituto de Biomedicina de Sevilla (IBiS), Seville, Spain. [Viciana,P] Infectious Diseases, Microbiology and Preventive Medicine, Hospital Universitario Virgen del Rocío, Seville, Spain. [Ojeda-Burgos,G] Unit of Infectious Diseases, Hospital Universitario Virgen de la Victoria, Malaga, Spain. [Delgado-Fernández,M] Unit of Infectious Diseases, Hospital Regional de Málaga, Malaga, Spain. [Ríos,MJ] Unit of Infectious Diseases, Hospital Universitario Virgen de la Macarena, Seville, Spain. [Merino,D] Unit of Infectious Diseases, Complejo Hospitalario de Huelva, Huelva, Spain. [Collado,A] Unit of Infectious Diseases, Hospital Torrecárdenas, Almeria, Spain. [Téllez,F] Unit of Infectious Diseases and Microbiology, Hospital La Línea, AGS Campo de Gibraltar, La Linea de la Concepcion, Spain.
Palabras clave : Hepatitis C
HIV
Homosexuality
Epidemics
Injecting drug use
Infectious diseases
Bilirrubina
Coinfección
Intervalos de confianza
Epidemias
Estudios de seguimiento
Infecciones por Vih
Homosexualidad
Hepatitis c
Inmunoglobulina G
Incidencia
Masculino
Prevalencia
Estudios retrospectivos
España
Seroconversión
MeSH: Medical Subject Headings::Chemicals and Drugs::Biological Factors::Pigments, Biological::Bile Pigments::Bilirubin
Medical Subject Headings::Diseases::Virus Diseases::Coinfection
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Confidence Intervals
Medical Subject Headings::Health Care::Environment and Public Health::Public Health::Disease Outbreaks::Epidemics
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Follow-Up Studies
Medical Subject Headings::Diseases::Immune System Diseases::Immunologic Deficiency Syndromes::HIV Infections
Medical Subject Headings::Organisms::Viruses::Hepatitis Viruses::Hepacivirus
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Globulins::Serum Globulins::Immunoglobulins::Antibodies::Immunoglobulin Isotypes::Immunoglobulin G
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Incidence
Medical Subject Headings::Check Tags::Male
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Prevalence
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Retrospective Studies
Medical Subject Headings::Geographicals::Geographic Locations::Europe::Spain
Medical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immune System Processes::Seroconversion
Fecha de publicación : 15-Sep-2016
Editorial : Biomed Central
Cita Bibliográfica: Neukam K, Viciana P, Ojeda-Burgos G, Delgado-Fernández M, Ríos MJ, Macías J, et al. No evidence of firstly acquired acute hepatitis C virus infection outbreak among HIV-infected patients from Southern Spain: a multicentric retrospective study from 2000-2014. BMC Infect Dis.. 2016; 16:489
Abstract: BACKGROUND Acute hepatitis C virus (HCV) infection (AHCVI) outbreaks have been described recently within defined areas worldwide among HIV-infected homosexual men. This study aims to describe the cumulative frequency and incidence of firstly acquired AHCVI in an HIV-infected population in Southern Spain. METHODS This is a retrospective study conducted at the Infectious Diseases Units of eight hospitals in Andalusia, Southern Spain. Primary AHC was considered as HCV immunoglobulin G antibody seroconversion. The time of infection was considered the moment between the last negative and the first positive HCV antibody determination. RESULTS A total of 23 cases of primary AHCVI have been detected from 2000 to 2014. Incidence rates [IR; 95 % confidence interval (CI)] were 0.036 (2.272-0.054) per 100 person-years (py) in the overall population over a follow-up period of 64170 py. Of the 22 (95.7 %) male subjects, 21 (95.5 %) had acquired AHCVI by homosexual contact, the IR (95 % CI) was 0.039 (0.024-0.06) per 100 py in this subpopulation. There was no evidence of an increase of AHCVI IR. The incidence of AHCVI was slightly lower between 2000 and 2004 as compared to 2005-2009 [IR ratio (IRR) of 8.8 (95 % CI: 1.279-378.794; p = 0.01)] but reached a plateau afterwards [IRR between 2010 and 2014 versus 2005-2009: 0.727 (0.286-1.848; p = 0.5)]. The median (Q1-Q3) time between the last negative anti-HCV and the first positive anti-HCV determination was 4.7 (1.9-11.2) months. Peak (Q1-Q3) ALT and total bilirubin values during AHCVI were 496 (291-656) IU/mL and 1.15 (0.9-1.98) mg/dL, respectively. CONCLUSIONS In contrast to what has been reported from other areas, the incidence of primary AHCVI in the HIV-infected population is stable in Southern Spain and there is no evidence of an epidemic, in spite of the high prevalence of HIV/HCV-coinfection in this area.
Descripción : Journal Article;
URI: http://hdl.handle.net/10668/2513
Versión del editor : https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-016-1826-2#Abs1
DOI: 10.1186/s12879-016-1826-2
ISSN : 1471-2334 (Online)
Appears in Collections:01- Artículos - AGS Campo de Gibraltar
01- Artículos - Complejo Hospitalario Torrecárdenas
01- Artículos - Complejo Hospitalario Universitario de Huelva
01- Artículos - Hospital Virgen Macarena
01- Artículos - Hospital Virgen de la Victoria
01- Artículos - Hospital Virgen del Rocío
01- Artículos - IBIS. Instituto de Biomedicina de Sevilla
01- Artículos - AGS Sur de Sevilla
01- Artículos - Hospital Regional de Málaga

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