Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/2516
Título : Clinical Subgroups in Bilateral Meniere Disease.
Autor : Frejo, Lidia
Soto-Varela, Andres
Santos-Perez, Sofía
Aran, Ismael
Batuecas-Caletrio, Angel
Perez-Guillen, Vanesa
Perez-Garrigues, Herminio
Fraile, Jesus
Martin-Sanz, Eduardo
Tapia, Maria C
Trinidad, Gabriel
García-Arumi, Ana María
González-Aguado, Rocío
Espinosa-Sanchez, Juan M
Marques, Pedro
Perez, Paz
Benitez, Jesus
Lopez-Escamez, Jose A
Filiación: [Frejo,L; Espinosa-Sanchez,JM; Lopez-Escamez,JA] Otology and Neurotology Group CTS495, Department of Genomic Medicine ,Centro de Genómica e Investigación Oncológica–Pfizer/Universidad de Granada/Junta de Andalucía (GENYO), Granada, Spain. [Soto-Varela,A; Santos-Perez,S] Department of Otorhinolaryngology, Division of Otoneurology, Complexo Hospitalario Universitario, Santiago de Compostela, Spain. [Aran,I] Department of Otolaryngology, Complexo Hospitalario de Pontevedra, Pontevedra, Spain. [Batuecas-Caletrio,A] Department of Otolaryngology, Hospital Universitario Salamanca, Salamanca, Spain. [Perez-Guillen,V; Perez-Garrigues,H] Department of Otorhinolaryngology, Hospital Universitario La Fe, Valencia, Spain. [Fraile,J] Department of Otolaryngology, Hospital Miguel Servet, Zaragoza, Spain. [Martin-Sanz,E] Department of Otolaryngology, Hospital Universitario de Getafe, Getafe, Spain. [Tapia,MC] Department of Otorhinolaryngology, Instituto Antolí Candela, Madrid, Spain. [Trinidad,G] Department of Otorhinolaryngology, Division of Otoneurology, Complejo Hospitalario Badajoz, Badajoz, Spain. [García-Arumi,AM] Department of Otorhinolaryngology, Hospital Universitario Vall d’Hebron, Barcelona, Spain. [González-Aguado,R;]Department of Otorhinolaryngology, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, Spain. [Espinosa-Sanchez,JM] Department of Otorhinolaryngology, Hospital San Agustin, Linares, Jaen, Spain. [Marques,P] Department of Otorhinolaryngology, Centro Hospitalar de São João, EPE, University of Porto Medical School, Porto, Portugal. [Perez,P] Department of Otorhinolaryngology, Hospital Cabueñes, Gijón, Spain. [Benitez,J] Department of Otolaryngology, Hospital Universitario de Gran Canaria Dr. Negrin, Las Palmas, Spain. [Lopez-Escamez,JA] Department of Otolaryngology, Instituto de Investigación Biosanitaria ibs.GRANADA, Complejo Hospitalario Universidad de Granada (CHUGRA), Granada, Spain.
Grupo de Investigación: The Meniere’s Disease Consortium (MeDiC)
Palabras clave : Cluster analysis
Vestibular disorders
Hearing loss
Tinnitus
Meniere’s disease
Migraine
Autoimmune disorders
Inner ear
Comorbilidad
Sordera
Pérdida auditiva
Pérdida auditiva sensorineural
Humanos
Enfermedad de Meniere
Trastornos migrañosos
Acúfeno
Vestíbulo del laberinto
MeSH: Medical Subject Headings::Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Epidemiologic Factors::Comorbidity
Medical Subject Headings::Diseases::Otorhinolaryngologic Diseases::Ear Diseases::Hearing Disorders::Hearing Loss::Deafness
Medical Subject Headings::Diseases::Otorhinolaryngologic Diseases::Ear Diseases::Hearing Disorders::Hearing Loss
Medical Subject Headings::Diseases::Otorhinolaryngologic Diseases::Ear Diseases::Hearing Disorders::Hearing Loss::Hearing Loss, Sensorineural
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Diseases::Otorhinolaryngologic Diseases::Ear Diseases::Labyrinth Diseases::Endolymphatic Hydrops::Meniere Disease
Medical Subject Headings::Diseases::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Headache Disorders::Headache Disorders, Primary::Migraine Disorders
Medical Subject Headings::Diseases::Otorhinolaryngologic Diseases::Ear Diseases::Hearing Disorders::Tinnitus
Medical Subject Headings::Anatomy::Sense Organs::Ear::Ear, Inner::Vestibule, Labyrinth
Fecha de publicación : 24-Oct-2016
Editorial : Frontiers Media
Cita Bibliográfica: Frejo L, Soto-Varela A, Santos-Perez S, Aran I, Batuecas-Caletrio A, Perez-Guillen V, et al. Clinical Subgroups in Bilateral Meniere Disease. Front Neurol. 2016; 7:182
Abstract: Meniere disease (MD) is a heterogeneous clinical condition characterized by sensorineural hearing loss, episodic vestibular symptoms, and tinnitus associated with several comorbidities, such as migraine or autoimmune disorders (AD). The frequency of bilateral involvement may range from 5 to 50%, and it depends on the duration of the disease. We have performed a two-step cluster analysis in 398 patients with bilateral MD (BMD) to identify the best predictors to define clinical subgroups with a potential different etiology to improve the phenotyping of BMD and to develop new treatments. We have defined five clinical variants in BMD. Group 1 is the most frequently found, includes 46% of patients, and is defined by metachronic hearing loss without migraine and without AD. Group 2 is found in 17% of patients, and it is defined by synchronic hearing loss without migraine or AD. Group 3, with 13% of patients, is characterized by familial MD, while group 4, that includes 12% of patients, is associated by the presence of migraine in all cases. Group 5 is found in 11% of patients and is defined by AD. This approach can be helpful in selecting patients for genetic and clinical research. However, further studies will be required to improve the phenotyping in these clinical variants for a better understanding of the diverse etiological factors contributing to BMD.
Descripción : Journal Article;
URI: http://hdl.handle.net/10668/2516
Versión del editor : http://journal.frontiersin.org/article/10.3389/fneur.2016.00182/full#h1
DOI: 10.3389/fneur.2016.00182
ISSN : 1664-2295 (Online)
Appears in Collections:01- Artículos - ibsGRANADA. Instituto de Investigación Biosanitaria de Granada
01- Artículos - Complejo Hospitalario Universitario de Granada

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