Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/252
Título : A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium
Autor : McKay, James D.
Truong, Therese
Gaborieau, Valerie
Chabrier, Amelie
Chuang, Shu-Chun
Byrnes, Graham
Zaridze, David
Shangina, Oxana
Szeszenia-Dabrowska, Neonila
Lissowska, Jolanta
Rudnai, Peter
Castellsagué, Xavier
Arzani, Dario
Lowry, Ray
Conway, David I.
Oszutowska, Dorota
McKinney, Patricia A.
Healy, Claire M.
Toner, Mary E.
Curado, Maria Paula
Menezes, Ana
Chen, Chu
Wünsch-Filho, Victor
Olshan, Andrew F.
Eluf Neto, José
Fernández Garrote, Leticia
Boccia, Stefania
Cadoni, Gabriella
Weissler, Mark C.
Zhang, Zuo-Feng
Funkhouser, William K.
Schwartz, Stephen M.
McClean, Michael D.
Luo, Jingchun
Lubiński, Jan
Trubicka, Joanna
Lener, Marcin
Fish, Sherianne
Doody, David R.
Manni, Johannes J.
Muscat, Joshua E.
Lazarus, Philip
Gallagher, Carla J.
Chang, Shen-Chih
Wei, Qingyi
Hung, Rayjean J.
Sturgis, Erich M.
Marsit, Carmen J.
Wang, Li-E
Franceschi, Silvia
Herrero, Rolando
Kelsey, Karl T.
Nelson, Heather H.
Vineis, Paolo
Romkes, Marjorie
Peters, Wilbert H. M.
Quirós, J. Ramón
Buch, Shama
Nukui, Tomoko
Zhong, Shilong
Lacko, Martin
McLaughlin, John
Vatten, Lars
Trichopoulou, Antonia
Njølstad, Inger
Goodman, Gary E.
Field, John K.
Liloglou, Triantafillos
Clavel-Chapelon, Francoise
Boeing, Heiner
Palli, Domenico
Martínez, Carmen
Tumino, Rosario
Krogh, Vittorio
Panico, Salvatore
González, Carlos A.
Navarro, Carmen
Voodern, Tõnu
Ardanaz, Eva
Linseisen, Jakob
Blanché, Hélène
Khaw, Kay-Tee
Key, Timothy
Bueno-de-Mesquita, Bas
Peeters, Petra H. M.
Hallmans, Göran
Overvad, Kim
Bucur, Alexandru
Tjønneland, Anne
Kumle, Merethe
Riboli, Elio
Välk, Kristjan
Metspalu, Andres
Janout, Vladimir
Zelenika, Diana
Gut, Ivo G.
Boland, Anne
Delepine, Marc
Foglio, Mario
Lechner, Doris
Galan, Pilar
Merletti, Franco
Heath, Simon
Bencko, Vladimir
Canova, Cristina
Hayes, Richard B.
Boffetta, Paolo
Lathrop, Mark
Brennan, Paul
Foretova, Lenka
Lagiou, Pagona
Richiardi, Lorenzo
Trichopoulos, Dimitrios
Benhamou, Simone
Bouchardy, Christine
Ahrens, Wolfgang
Talamini, Renato
Koifman, Sergio
Barzan, Luigi
Agudo, Antonio
Kjaerheim, Kristina
Macfarlane, Gary J.
Macfarlane, Tatiana V.
Simonato, Lorenzo
Filiación: [McKay, JD;Truong, T;Gaborieau, V;Chabrier, A;Chuang, SC;Byrnes, G;Curado, MP;Franceschi, S;Hashibe, M;Boffetta, P;Brennan, P] IARC, Lyon, France. [Zaridze, D;Shangina, O] Russian Acad Med Sci, Canc Res Ctr, Inst Carcinogenesis, Moscow, Russia. [Szeszenia-Dabrowska, N] Inst Occupat Med, Dept Epidemiol, Lodz, Poland. [Lissowska, J] M Sklodowska Curie Mem Canc Ctr, Warsaw, Poland. [Lissowska, J] Inst Oncol, Warsaw, Poland. [Rudnai, P] Natl Inst Environm Hlth, Budapest, Hungary. [Fabianova, E] Reg Author Publ Hlth, Banska Bystrica, Slovakia. [Bucur, A] Inst Publ Hlth, Bucharest, Romania. [Bencko, V;Holcatova, I] Charles Univ Prague, Inst Hyg & Epidemiol, Fac Med 1, Prague, Czech Republic. [Janout, V] Palacky Univ, CR-77147 Olomouc, Czech Republic. [Foretova, L] Masaryk Mem Canc Inst, Dept Canc Epidemiol & Genet, Brno, Czech Republic. [Trichopoulos, D] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. [Benhamou, S] INSERM U946, Paris, France. [Benhamou, S] Inst Gustave Roussy, CNRS UMR8200, Villejuif, France. [Bouchardy, C] Univ Geneva, Geneva Canc Registry, Inst Social & Prevent Med, Geneva, Switzerland. [Ahrens, W] Univ Bremen, Bremen Inst Prevent Res & Social Med BIPS, Bremen, Germany. [Merletti, F;Richiardi, L] Univ Turin, Canc Epidemiol Unit, Turin, Italy. [Talamini, R] IRCCS, Natl Canc Inst, Aviano, Italy. [Barzan, L] Gen Hosp Pordenone, Pordenone, Italy. [Kjaerheim, K] Canc Registry Norway, Oslo, Norway. [Macfarlane, GJ;Macfarlane, TV] Univ Aberdeen, Sch Med & Dent, Aberdeen, Scotland. [Simonato, L;Canova, C] Univ Padua, Dept Environm Med & Publ Hlth, Padua, Italy. [Canova, C] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London, England. [Agudo, A;Castellsague, X] ICO, Barcelona, Spain. [Castellsague, X;Navarro, C;Ardanaz, E] CIBERESP, Madrid, Spain. [Lowry, R] Univ Newcastle Dent Sch, Newcastle Upon Tyne, Tyne & Wear, England. [Conway, DI] Univ Glasgow Dent Sch, Glasgow, Lanark, Scotland. [McKinney, PA] Univ Leeds Ctr Epidemiol & Biostat, Leeds, W Yorkshire, England. [McKinney, PA] NHS NSS ISD, Edinburgh, Midlothian, Scotland. [Healy, CM;Toner, ME] Trinity Coll Sch Dent Sci, Dublin, Ireland. [Znaor, A] Croatian Natl Inst Publ Hlth, Croatian Natl Canc Registry, Zagreb, Croatia. [Koifman, S] Natl Sch Publ Hlth FIOCRUZ, Rio De Janeiro, Brazil. [Menezes, A] Univ Fed Pelotas, Pelotas, Brazil. [Wuensch, V;Neto, JE] Univ Sao Paulo, Sao Paulo, Brazil. [Garrote, LF] Inst Oncol & Radiobiol, Havana, Cuba. [Boccia, S;Cadoni, G;Arzani, D] Univ Cattolica Sacro Cuore, Inst Hyg, Rome, Italy. [Boccia, S] IRCCS San Raffaele Pisana, Rome, Italy. [Olshan, AF] Univ N Carolina, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA. [Weissler, MC;Funkhouser, WK;Luo, JC] Univ N Carolina, Sch Med, Chapel Hill, NC USA. [Lubinski, J;Trubicka, J;Lener, M;Oszutowska, D] Pomeranian Med Univ, Dept Genet & Pathomorphol, Int Hereditary Canc Ctr, Szczecin, Poland. [Oszutowska, D] Pomeranian Med Univ, Dept Hyg Epidemiol & Publ Hlth, Szczecin, Poland. [Schwartz, SM;Chen, C;Fish, S;Doody, DR;Goodman, GE] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. [Muscat, JE;Lazarus, P;Gallagher, CJ] Penn State Coll Med, Hershey, PA USA. [Chang, SC;Zhang, ZF] Univ Calif Los Angeles Sch Publ Hlth, Los Angeles, CA USA. [Wei, QY;Sturgis, EM;Wang, LE] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. [Herrero, R] Inst Invest Epidemiol, San Jose, Costa Rica. [Kelsey, KT;Marsit, CJ] Brown Univ, Providence, RI 02912 USA. [McClean, MD] Boston Univ Sch Publ Hlth, Boston, MA USA. [Nelson, HH] Univ Minnesota, Mason Canc Ctr, Minneapolis, MN USA. [Romkes, M;Buch, S;Nukui, T;Zhong, SL] Univ Pittsburgh, Pittsburgh, PA USA. [Lacko, M;Manni, JJ] Maastricht Univ Med Ctr, Dept Otorhinolaryngol & Head & Neck Surg, Maastricht, Netherlands. [Peters, WHM] St Radboud Univ Nijmegen Med Ctr, Dept Gastroenterol, Nijmegen, Netherlands. [Hung, RJ] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada. [McLaughlin, J] Canc Care Ontario, Toronto, ON, Canada. [Vatten, L] Norwegian Univ Sci & Technol, N-7034 Trondheim, Norway. [Njolstad, I] Univ Tromso, Dept Community Med, Fac Hlth Sci, Tromso, Norway. [Field, JK;Liloglou, T] Univ Liverpool Canc Res Ctr, Roy Castle Lung Canc Res Programme, Liverpool, Merseyside, England. [Vineis, P] Univ Turin, Serv Epidemiol Tumori, Turin, Italy. [Vineis, P] CPO Piemonte, Turin, Italy. [Vineis, P;Riboli, E] Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Publ Hlth, London, England. [Clavel-Chapelon, F] E3N EPIC Grp Inst Gustave Roussy, INSERM, Villejuif, France. [Palli, D] Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy. [Tumino, R] Azienda Osped Civile MP Arezzo, Canc Registry, Ragusa, Italy. [Tumino, R] Azienda Osped Civile MP Arezzo, Histopathol Unit, Ragusa, Italy. [Krogh, V] Fdn IRCCS, Ist Nazl Tumori, Milan, Italy. [Panico, S] Univ Naples Federico 2, Dipartimento Med Clin & Sperimentale, Naples, Italy. [Gonzalez, CA] ICO, RETICC DR06 0020, IDIBELL, Unit Nutr Environm & Canc, Barcelona, Spain. [Quiros, JR] Principado Asturias, Consejeria Serv Sociales, Jefe Secc Informac Sanitaria, Oviedo, Spain. [Martinez, C] Escuela Andaluza Salud Publ, Granada, Spain. [Navarro, C] Murcia Hlth Council, Dept Epidemiol, Murcia, Spain. [Ardanaz, E] Navarra Publ Hlth Inst, Pamplona, Spain. [Larranaga, N] Gobierno Vasco, Subdirecc Salud Publ Gipuzkoa, San Sebastian, Spain. [Khaw, KT] Univ Cambridge, Sch Clin Med, Cambridge, England. [Key, T] Univ Oxford, Canc Res UK, Oxford, England. [Bueno-de-Mesquita, HB] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands. [Peeters, PHM] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Dept Epidemiol, Utrecht, Netherlands. [Trichopoulou, A] Univ Athens Sch Med, WHO Collaborating Ctr Nutr, Dept Hyg Epidemiol & Med Stat, Athens, Greece. [Linseisen, J] Helmholtz Ctr Munich, Inst Epidemiol, Neuherberg, Germany. [Linseisen, J] German Canc Res Ctr, Div Clin Epidemiol, D-6900 Heidelberg, Germany. [Boeing, H] Deutsch Inst Ernahrungsforsch, Dept Epidemiol, Potsdam, Germany. [Hallmans, G] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden. [Overvad, K] Aarhus Univ, Dept Epidemiol & Social Med, Aarhus, Denmark. Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark. [Kumle, M] Univ Hosp No Norway, Tromso, Norway. [Valk, K;Voodern, T;Metspalu, A] Univ Tartu, EE-50090 Tartu, Estonia. [Zelenika, D;Boland, A;Delepine, M;Foglio, M;Lechner, D;Gut, IG;Heath, S;Lathrop, M] Commissariat Energie Atom, Inst Genom, Ctr Natl Genotypage, Evry, France. [Blanche, H;Lathrop, M] Fdn Jean Dausset CEPH, Paris, France. [Galan, P] Univ Paris 13, INSERM INRA CNAM U557 U1125, Bobigny, France. [Hayes, RB] New York Univ Langone Med Ctr, New York, NY USA
Palabras clave : Estudio de Asociación del Genoma Completo
Neoplasias de Cabeza y Cuello
Estudio Multicéntrico
INHANCE Consortium
MeSH: Medical Subject Headings::Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Epidemiologic Research Design::Genome-Wide Association Study
Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Head and Neck Neoplasms
Medical Subject Headings::Publication Characteristics::Study Characteristics::Multicenter Study
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Susceptibility::Genetic Predisposition to Disease
Medical Subject Headings::Persons::Persons::Population Groups::Continental Population Groups
Fecha de publicación : 17-Mar-2011
Editorial : Public Library of Science
Cita Bibliográfica: McKay JD, Truong T, Gaborieau V, Chabrier A, Chuang SC, Byrnes G, et al. A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium. PLoS Genet. 2011 Mar; 7 (3) :e1001333
Abstract: Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease. We conducted a GWAS to identify common genetic variation involved in susceptibility to upper aero-digestive tract (UADT) cancers. Genome-wide genotyping was carried out using the Illumina HumanHap300 beadchips in 2,091 UADT cancer cases and 3,513 controls from two large European multi-centre UADT cancer studies, as well as 4,821 generic controls. The 19 top-ranked variants were investigated further in an additional 6,514 UADT cancer cases and 7,892 controls of European descent from an additional 13 UADT cancer studies participating in the INHANCE consortium. Five common variants presented evidence for significant association in the combined analysis (p≤5×10−7). Two novel variants were identified, a 4q21 variant (rs1494961, p = 1×10−8) located near DNA repair related genes HEL308 and FAM175A (or Abraxas) and a 12q24 variant (rs4767364, p = 2×10−8) located in an extended linkage disequilibrium region that contains multiple genes including the aldehyde dehydrogenase 2 (ALDH2) gene. Three remaining variants are located in the ADH gene cluster and were identified previously in a candidate gene study involving some of these samples. The association between these three variants and UADT cancers was independently replicated in 5,092 UADT cancer cases and 6,794 controls non-overlapping samples presented here (rs1573496-ADH7, p = 5×10−8; rs1229984-ADH1B, p = 7×10−9; and rs698-ADH1C, p = 0.02). These results implicate two variants at 4q21 and 12q24 and further highlight three ADH variants in UADT cancer susceptibility.
URI: http://hdl.handle.net/10668/252
Versión del editor : http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1001333
DOI: 10.1371/journal.pgen.1001333
Appears in Collections:01- Artículos - EASP. Escuela Andaluza de Salud Pública

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