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Title: New Approaches to Overcome Transport Related Drug Resistance in Trypanosomatid Parasites.
Authors: Garcia-Salcedo, Jose A
Unciti-Broceta, Juan D
Valverde-Pozo, Javier
Soriano, Miguel
metadata.dc.contributor.authoraffiliation: [Garcia-Salcedo,JA; Unciti-Broceta, JD; Valverde-Pozo,J] Unidad de Enfermedades Infecciosas y Microbiología, Instituto de Investigación Biosanitaria, ibs.GRANADA. Hospitales Universitarios de Granada, Universidad de Granada, Granada, Spain. [Garcia-Salcedo,JA;Valverde-Pozo,J; Soriano,M] Centro de Genómica e Investigación Oncológica – Pfizer/Universidad de Granada/Junta de Andalucía, Granada, Spain. [Soriano,M] Departamento de Agronomía, Universidad de Almería, Almería, Spain.
Keywords: Trypanosomatid parasites;Drug transport;Surface transporter;Efflux pumps;Drug resistance,;Nanocarriers;Animales;Portadores de fármacos;Países en desarrollo;Enfermedad de Chagas;Humanos;Proteínas de transporte de membrana;Mutación;Parásitos;Tripanosomiasis Africana;Vacunas
metadata.dc.subject.mesh: Medical Subject Headings::Organisms::Eukaryota::Animals
Medical Subject Headings::Diseases::Parasitic Diseases::Protozoan Infections::Euglenozoa Infections::Trypanosomiasis::Chagas Disease
Medical Subject Headings::Disciplines and Occupations::Social Sciences::Internationality::International Cooperation::Developing Countries
Medical Subject Headings::Chemicals and Drugs::Pharmaceutical Preparations::Dosage Forms::Drug Carriers
Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Pharmacological Phenomena::Drug Resistance
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Organisms::Eukaryota::Euglenozoa::Kinetoplastida::Trypanosomatina::Leishmania
Medical Subject Headings::Diseases::Parasitic Diseases::Protozoan Infections::Euglenozoa Infections::Leishmaniasis
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Carrier Proteins::Membrane Transport Proteins
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation
Medical Subject Headings::Organisms::Eukaryota::Animals::Invertebrates::Parasites
Medical Subject Headings::Organisms::Eukaryota::Euglenozoa::Kinetoplastida::Trypanosomatina::Trypanosoma
Medical Subject Headings::Diseases::Parasitic Diseases::Protozoan Infections::Euglenozoa Infections::Trypanosomiasis::Trypanosomiasis, African
Medical Subject Headings::Chemicals and Drugs::Complex Mixtures::Biological Agents::Vaccines
Issue Date: 28-Sep-2016
Publisher: Frontiers Media
Citation: Garcia-Salcedo JA, Unciti-Broceta JD, Valverde-Pozo J, Soriano M. New Approaches to Overcome Transport Related Drug Resistance in Trypanosomatid Parasites. Front Pharmacol. 2016; 7:351
Abstract: Leishmania and Trypanosoma are members of the Trypanosomatidae family that cause severe human infections such as leishmaniasis, Chagas disease, and sleeping sickness affecting millions of people worldwide. Despite efforts to eradicate them, migrations are expanding these infections to developing countries. There are no vaccines available and current treatments depend only on chemotherapy. Drug resistance is a major obstacle for the treatment of these diseases given that existing drugs are old and limited, with some having severe side effects. Most resistance mechanisms developed by these parasites are related with a decreased uptake or increased efflux of the drug due to mutations or altered expression of membrane transporters. Different new approaches have been elaborated that can overcome these mechanisms of resistance including the use of inhibitors of efflux pumps and drug carriers for both active and passive targeting. Here we review new formulations that have been successfully applied to circumvent resistance related to drug transporters, opening alternative ways to solve drug resistance in protozoan parasitic diseases.
metadata.dc.identifier.doi: 10.3389/fphar.2016.00351
ISSN: 1663-9812 (Online)
Appears in Collections:01- Artículos - Complejo Hospitalario Universitario de Granada
01- Artículos - GENYO. Centro Pfizer-Andalucía de Genómica e Investigación Oncológica
01- Artículos - ibsGRANADA. Instituto de Investigación Biosanitaria de Granada

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