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http://hdl.handle.net/10668/2533| Title: | Hepatic safety of RPV/FTC/TDF single tablet regimen in HIV/HCV-coinfected patients. Preliminary results of the hEPAtic Study |
| Authors: | Neukam, Karin Espinosa, Nuria Merino, Dolores Rivero-Juárez, Antonio Carrero, Ana Ríos, María José Ruiz-Morales, Josefa Gómez-Berrocal, Ana Téllez, Francisco Díaz-Menéndez, Marta Collado, Antonio Pérez-Camacho, Inés Delgado-Fernández, Marcial Vera-Méndez, Francisco Pineda, Juan A. |
| metadata.dc.contributor.authoraffiliation: | [Neukam,K] Unit of Infectious Diseases and Microbiology, Hospital Universitario de Valme, Seville, Spain. [Espinosa,N] Service of Infectious Diseases, Hospital Universitario Virgen del Rocío,Seville, Spain. [Merino,D] Unit of Infectious Diseases, Complejo Hospitalario de Huelva, Huelva, Spain. [Rivero-Juárez,A] Unit of Infectious Diseases, Hospital Universitario Reina Sofía, Instituto de Investigación Biomédica de Córdoba (IMIBIC), Cordoba, Spain. [Carrero,A] Unit of Infectious Diseases/HIV, Hospital General Universitario Gregorio Marañón, Madrid, Spain. [Ríos,MJ] Unit of Infectious Diseases, Hospital Virgen Macarena, Seville, Spain. [Ruiz-Morales,J] Unit of Infectious Diseases, Hospital Universitario Virgen de la Victoria, Malaga, Spain. [Gómez-Berrocal,A] Service of Internal Medicine/Infectious Diseases, Hospital Universitario de la Princesa, Madrid, Spain. [Téllez,F] CMU of Infectious Diseases and Microbiology, Hospital La Línea, AGS Campo de Gibraltar, La Linea de la Concepcion, Spain. [Díaz-Menéndez,M] Internal Medicine and Infectious Diseases, Hospital Universitario La Paz/IdiPAZ, Madrid, Spain. [Collado,A] Unit of Infectious Diseases, Hospital Torrecárdenas, Almeria, Spain. [Pérez-Camacho,I] Unit of Tropical Medicine, Hospital Poniente, El Ejido, Spain. [Delgado-Fernández,M] Service of Infectious Diseases, Hospital Regional de Málaga, Malaga, Spain. [Vera-Méndez,F] Section of Infectious Medicine, Hospital Universitario Santa Lucia, Cartagena, Spain. [Pineda,JA] Unit of Infectious Diseases, Hospital Universitario de Valme, Seville, Spain. |
| Keywords: | Bilirrubina;Protocolos clínicos;Coinfección;Hepatitis C;Combinación emtricitabina, rilpivirina y tenofovir |
| metadata.dc.subject.mesh: | Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Azoles::Pyrroles::Tetrapyrroles::Bile Pigments::Bilirubin Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Clinical Protocols Medical Subject Headings::Diseases::Bacterial Infections and Mycoses::Infection::Coinfection Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents Medical Subject Headings::Diseases::Virus Diseases::Hepatitis, Viral, Human::Hepatitis C Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Follow-Up Studies Medical Subject Headings::Diseases::Virus Diseases::RNA Virus Infections::Retroviridae Infections::Lentivirus Infections::HIV Infections Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Incidence Medical Subject Headings::Anatomy::Digestive System::Liver Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Nitriles::RilpivirineEmtricitabine, Rilpivirine, Tenofovir Drug Combination Medical Subject Headings::Geographicals::Geographic Locations::Europe::Spain Medical Subject Headings::Chemicals and Drugs::Pharmaceutical Preparations::Dosage Forms::Tablets Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Nitrogenous Group Transferases::Transaminases |
| Issue Date: | 2-Nov-2014 |
| Publisher: | BioMed Central |
| Citation: | Neukam K, Espinosa N, Merino D, Rivero-Juárez A, Carrero A, Ríos Mj, et al. Hepatic safety of RPV/FTC/TDF single tablet regimen in HIV/HCV-coinfected patients. Preliminary results of the hEPAtic Study. J Int AIDS Soc.. 2014, 17(Suppl 3):19631 |
| Abstract: | Although hepatotoxicity related to antiretroviral treatment (ART) has become less frequent, hepatotoxic events, such as transaminase elevations (TE), are still a matter of concern. RPV/FTC/TDF (EPA) is a new single tablet regimen which is widely used in real life practice. Clinical trials showed an adequate profile of liver safety in the sub-population of HIV/HCV- coinfected patients receiving rilpivirine. However, the number of individuals included in these analyses is low [1]. The aim of this ongoing study is to evaluate the incidence of TE and total bilirubin elevations (TBE) during the first 48 weeks of EPA-based therapy in a large population of HIV/HCV-coinfected subjects outside of clinical trials. |
| URI: | http://hdl.handle.net/10668/2533 |
| metadata.dc.relation.publisherversion: | http://www.jiasociety.org/index.php/jias/article/view/19631 |
| metadata.dc.identifier.doi: | 10.7448/IAS.17.4.19631 |
| ISSN: | 1758-2652 (Online) |
| Appears in Collections: | 01- Artículos - AGS Campo de Gibraltar 01- Artículos - AGS Sur de Sevilla 01- Artículos - APES Hospital de Poniente 01- Artículos - Complejo Hospitalario Torrecárdenas 01- Artículos - Complejo Hospitalario Universitario de Huelva 01- Artículos - Hospital Regional de Málaga 01- Artículos - Hospital Reina Sofía 01- Artículos - Hospital Virgen de la Victoria 01- Artículos - Hospital Virgen del Rocío 01- Artículos - Hospital Virgen Macarena 01- Artículos - IMIBIC. Instituto Maimónides de Investigación Biomédica de Córdoba |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| neukanK_HepaticSafety.pdf | Poster | 76,14 kB | Adobe PDF | View/Open |
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