1. Repositorio Salud Andalucía
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  3. Sevilla
  4. Hospital Virgen Macarena
  5. 01- Artículos - Hospital Virgen Macarena
Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/2534
Title: High MICs for Vancomycin and Daptomycin and Complicated Catheter-Related Bloodstream Infections with Methicillin-Sensitive Staphylococcus aureus.
Authors: San-Juan, Rafael
Viedma, Esther
Chaves, Fernando
Lalueza, Antonio
Fortún, Jesús
Loza, Elena
Pujol, Miquel
Ardanuy, Carmen
Morales, Isabel
de Cueto, Marina
Resino-Foz, Elena
Morales-Cartagena, Alejandra
Rico, Alicia
Romero, María P
Orellana, María Ángeles
López-Medrano, Francisco
Fernández-Ruiz, Mario
Aguado, José María
metadata.dc.contributor.authoraffiliation: [San-Juan,R; Viedma,E; Chaves,F; Lalueza,A; Resino-Foz,E; Morales-Cartagena,A; Orellana,MA; López-Medrano,F; Fernández-Ruiz,M; Aguado,JM] University Hospital–Research Institute 12 de Octubre, Madrid, Spain. [Fortún,J; Loza,E] Hospital Universitario Ramón y Cajal, Madrid, Spain. [Pujol,M; Ardanuy,C] University Hospital–Bellvitge Institute for Biomedical Research, Barcelona, Spain. [Morales,I; de Cueto,M] Hospital Universitario Virgen de la Macarena, Seville, Spain. [Rico,A; Romero,MP] Hospital Universitario La Paz, Madrid. Spain.
Keywords: CRBI;MIC;MSSA;bacteria;Catheter-related bloodstream infection;Complicated bacteremia;Daptomycin;Methicillin-sensitive Staphylococcus aureus;Septic thrombophlebitis;Vancomycin;Bacteriemia;Infecciones relacionadas con catéteres;Daptomicina;Meticilina;Análisis multivariante;Oxacilina;Vancomicina
metadata.dc.subject.mesh: Medical Subject Headings::Diseases::Bacterial Infections and Mycoses::Bacterial Infections::Bacteremia
Medical Subject Headings::Diseases::Bacterial Infections and Mycoses::Infection::Catheter-Related Infections
Medical Subject Headings::Chemicals and Drugs::Polycyclic Compounds::Macrocyclic Compounds::Peptides, Cyclic::Daptomycin
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amides::Lactams::beta-Lactams::Penicillins::Methicillin
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Microbiological Techniques::Microbial Sensitivity Tests
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Analysis of Variance::Multivariate Analysis
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amides::Lactams::beta-Lactams::Penicillins::Oxacillin
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors
Medical Subject Headings::Geographicals::Geographic Locations::Europe::Spain
Medical Subject Headings::Diseases::Bacterial Infections and Mycoses::Bacterial Infections::Gram-Positive Bacterial Infections::Staphylococcal Infections
Medical Subject Headings::Organisms::Bacteria::Endospore-Forming Bacteria::Gram-Positive Endospore-Forming Bacteria::Gram-Positive Endospore-Forming Rods::Staphylococcaceae::Staphylococcus::Staphylococcus aureus
Medical Subject Headings::Chemicals and Drugs::Carbohydrates::Glycoconjugates::Glycopeptides::Vancomycin
Issue Date: Jun-2016
Publisher: Centers for Disease Control and Prevention
Citation: San-Juan R, Viedma E, Chaves F, Lalueza A, Fortún J, Loza E, et al. High MICs for Vancomycin and Daptomycin and Complicated Catheter-Related Bloodstream Infections with Methicillin-Sensitive Staphylococcus aureus. Emerging Infect Dis. 2016; 22(6):1057-66
Abstract: We investigated the prognostic role of high MICs for antistaphylococcal agents in patients with methicillin-sensitive Staphylococcus aureus catheter-related bloodstream infection (MSSA CRBSI). We prospectively reviewed 83 episodes from 5 centers in Spain during April 2011-June 2014 that had optimized clinical management and analyzed the relationship between E-test MICs for vancomycin, daptomycin, oxacillin, and linezolid and development of complicated bacteremia by using multivariate analysis. Complicated MSSA CRBSI occurred in 26 (31.3%) patients; MICs for vancomycin and daptomycin were higher in these patients (optimal cutoff values for predictive accuracy = 1.5 μg/mL and 0.5 μg/mL). High MICs for vancomycin (hazard ratio 2.4, 95% CI 1.2-5.5) and daptomycin (hazard ratio 2.4, 95% CI 1.1-5.9) were independent risk factors for development of complicated MSSA CRBSI. Our data suggest that patients with MSSA CRBSI caused by strains that have high MICs for vancomycin or daptomycin are at increased risk for complications.
Description: Journal Article;
URI: http://hdl.handle.net/10668/2534
metadata.dc.relation.publisherversion: http://wwwnc.cdc.gov/eid/article/22/6/15-1709_article
metadata.dc.identifier.doi: 10.3201/eid2206.151709
ISSN: 1080-6059 (Online)
1080-6040 (Print)
Appears in Collections:01- Artículos - Hospital Virgen Macarena

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