Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/2542
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dc.contributor.authorRamírez-López, María Teresa-
dc.contributor.authorArco, Raquel-
dc.contributor.authorDecara, Juan-
dc.contributor.authorVázquez, Mariam-
dc.contributor.authorBlanco, Rosario Noemí-
dc.contributor.authorAlén, Francisco-
dc.contributor.authorSuárez, Juan-
dc.contributor.authorGómez de Heras, Raquel-
dc.contributor.authorRodríguez de Fonseca, Fernando-
dc.date.accessioned2016-11-25T09:04:35Z-
dc.date.available2016-11-25T09:04:35Z-
dc.date.issued2016-11-02-
dc.identifier.citationRamírez-López MT, Arco R, Decara J, Vázquez M, Blanco RN, Alén F, et al. Exposure to a Highly Caloric Palatable Diet during the Perinatal Period Affects the Expression of the Endogenous Cannabinoid System in the Brain, Liver and Adipose Tissue of Adult Rat Offspring. PLoS ONE. 2016; 11(11):e0165432es
dc.identifier.issn1932-6203 (Online)-
dc.identifier.otherPMC5091916-
dc.identifier.urihttp://hdl.handle.net/10668/2542-
dc.descriptionJournal Article;es
dc.description.abstractRecent studies have linked gestational exposure to highly caloric diets with a disrupted endogenous cannabinoid system (ECS). In the present study, we have extended these studies by analyzing the impact of the exposure to a palatable diet during gestation and lactation on a) the adult expression of endocannabinoid-related behaviors, b) the metabolic profile of adult offspring and c) the mRNA expression of the signaling machinery of the ECS in the hypothalamus, the liver and the adipose tissue of adult offspring of both sexes. Exposure to a palatable diet resulted in a) sex-dimorphic and perinatal diet specific feeding behaviors, including the differential response to the inhibitory effects of the cannabinoid receptor inverse agonist AM251, b) features of metabolic syndrome including increased adiposity, hyperleptinemia, hypertriglyceridemia and hypercholesterolemia and c) tissue and sex-specific changes in the expression of both CB1 and CB2 receptors and in that of the endocannabinoid-degrading enzymes FAAH and MAGL, being the adipose tissue the most affected organ analyzed. Since the effects were observed in adult animals that were weaned while consuming a normal diet, the present results indicate that the ECS is one of the targets of maternal programming of the offspring energy expenditure. These results clearly indicate that the maternal diet has long-term effects on the development of pups through multiple alterations of signaling homeostatic pathways that include the ECS. The potential relevance of these alterations for the current obesity epidemic is discussed.es
dc.description.sponsorshipThis work was supported by the Instituto de Salud Carlos III UEDR-FEDER, Ministerio de Economía y Competitividad UE/ERDF (PI13/0226 to F.R.F., CP12/03109 to J.S. and PSI-2012-35388 to R.G.H.), Red de Trastornos Adictivos UE/ERDF (RD12/0028/0001 to F.R.F.), CIBERobn, Consejería de Economía, Innovación y Ciencia, Junta de Andalucía, UE/ERDF (PI45403, CTS-8221, CTS-433 to F.R.F.), Consejería de Salud, Junta de Andalucía (PI0232/2008, PI0029/2008 and SAS111224 to J. S. and F.R.F. M.T. Ramírez-López has been funded by a FPU predoctoral fellowship of the Spanish Ministerio de Educación, Cultura y Deporte (AP- 2009-0225); J.S. holds “Miguel Servet”research contract from the National System of Health, ISCIII (grant numbersCP12/03109).es
dc.language.isoenes
dc.publisherPublic Libray of Sciencees
dc.relation.ispartofPloS Onees
dc.subjectTejido adiposoes
dc.subjectAdiposidades
dc.subjectNiños Adultoses
dc.subjectAnimaleses
dc.subjectCannabinoideses
dc.subjectDietaes
dc.subjectEndocannabinoideses
dc.subjectMetabolismo Energéticoes
dc.subjectConducta alimentariaes
dc.subjectFemeninoes
dc.subjectHipercolesterolemiaes
dc.subjectHipertrigliceridemiaes
dc.subjectHipotálamoes
dc.subjectLactanciaes
dc.subjectHígadoes
dc.subjectMasculinoes
dc.subjectMetabolomaes
dc.subjectObesidades
dc.subjectEmbarazoes
dc.subjectARN mensajeroes
dc.subjectReceptor cannabinoide CB2es
dc.subjectDestetees
dc.subject.meshMedical Subject Headings::Anatomy::Tissues::Connective Tissue::Adipose Tissuees
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Body Composition::Body Fat Distribution::Adiposityes
dc.subject.meshMedical Subject Headings::Named Groups::Persons::Adult Childrenes
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animalses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Terpenes::Cannabinoidses
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Dietes
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Neurotransmitter Agents::Endocannabinoidses
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Energy Metabolismes
dc.subject.meshMedical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Feeding Behaviores
dc.subject.meshMedical Subject Headings::Check Tags::Femalees
dc.subject.meshMedical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Lipid Metabolism Disorders::Dyslipidemias::Hyperlipidemias::Hypercholesterolemiaes
dc.subject.meshMedical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Lipid Metabolism Disorders::Dyslipidemias::Hyperlipidemias::Hypertriglyceridemiaes
dc.subject.meshMedical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain::Limbic System::Hypothalamuses
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Lactationes
dc.subject.meshMedical Subject Headings::Anatomy::Digestive System::Liveres
dc.subject.meshMedical Subject Headings::Check Tags::Malees
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolomees
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Size::Body Weight::Overweight::Obesityes
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Reproduction::Pregnancyes
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::RNA::RNA, Messengeres
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, G-Protein-Coupled::Receptors, Cannabinoid::Receptor, Cannabinoid, CB2es
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Nutrition Processes::Weaninges
dc.titleExposure to a Highly Caloric Palatable Diet during the Perinatal Period Affects the Expression of the Endogenous Cannabinoid System in the Brain, Liver and Adipose Tissue of Adult Rat Offspring.es
dc.typeinfo:eu-repo/semantics/articlees
dc.description.versionYeses
dc.identifier.pmid27806128-
dc.rights.accessRightsAcceso abiertoes
dc.identifier.doi10.1371/journal.pone.0165432-
dc.type.versioninfo:eu-repo/semantics/publishedes
dc.relation.publisherversionhttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0165432es
dc.contributor.authoraffiliation[Ramírez-López,MT; Blanco, RN; Gómez De Heras, R] Departamento de Psicobiología, Facultad de Psicología, Universidad Complutense de Madrid, Pozuelo de Alarcón, Madrid, Spain. [Arco,R; Decara,J; Vázquez,M; Alén,F; Suárez, J Rodríguez de Fonseca,F] Instituto de Investigación Biomédica de Málaga [IBIMA), Unidad de Gestión Clínica de Salud Mental, Hospital Regional Universitario de Málaga, Universidad de Málaga, Málaga, Spain.es
dc.type.subtypeArtículoes
Appears in Collections:01- Artículos - IBIMA. Instituto de Investigación Biomédica de Málaga
01- Artículos - Hospital Regional de Málaga

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