Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/2561
Título : Maternal Caloric Restriction Implemented during the Preconceptional and Pregnancy Period Alters Hypothalamic and Hippocampal Endocannabinoid Levels at Birth and Induces Overweight and Increased Adiposity at Adulthood in Male Rat Offspring.
Autor : Ramírez-López, María Teresa
Vázquez, Mariam
Bindila, Laura
Lomazzo, Ermelinda
Hofmann, Clementine
Blanco, Rosarío Noemí
Alén, Francisco
Antón, María
Decara, Juan
Arco, Rocío
Ouro, Daniel
Orio, Laura
Suárez, Juan
Lutz, Beat
Gómez de Heras, Raquel
Rodríguez de Fonseca, Fernando
Filiación: [Ramírez-López,MT; Vázquez,M; Blanco,RN; Alén,F; Antón,M; Ouro,D; Orio,L; Gómez de las Heras,R; Rodriguez de Fonseca,F] Departamento de Psicobiología, Facultad de Psicología, Universidad Complutense de Madrid, Madrid, Spain. [Vázquez,M; Decara,J; Arco,R; Suárez,J; Rodríguez de Fonseca,F] Instituto de Investigación Biomédica de Málaga (IBIMA), Unidad de Gestión Clínica de Salud Mental, Hospital Regional Universitario de Málaga, Universidad de Málaga, Málaga, Spain. [Bindila,L; Lomazzo,E; Hormann,C; Lutz,B] Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany.
Palabras clave : Maternal urdernutrition
Endocannabinoids
Endocannabinoids
Hypothalamus
Hyppocampus
Rat
Development
Metabolism
Behavior
Adaptación psicológica
Adiposidad
Ansiedad
Ácidos araquidónicos
Restricción calórica
Endocannabinoides
Metabolismo Energético
Hipocampo
Hipotálamo
Embarazo
Ratas
MeSH: Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Adaptation, Psychological
Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Body Composition::Body Fat Distribution::Adiposity
Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Emotions::Anxiety
Medical Subject Headings::Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids, Unsaturated::Arachidonic Acids
Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet::Energy Intake::Caloric Restriction
Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Neurotransmitter Agents::Endocannabinoids
Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Energy Metabolism
Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain::Limbic System::Hippocampus
Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain::Limbic System::Hypothalamus
Medical Subject Headings::Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Reproduction::Pregnancy
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats
Fecha de publicación : 1-Nov-2016
Editorial : Frontiers Media
Cita Bibliográfica: Ramírez-López MT, Vázquez M, Bindila L, Lomazzo E, Hofmann C, Blanco RN, et al. Maternal Caloric Restriction Implemented during the Preconceptional and Pregnancy Period Alters Hypothalamic and Hippocampal Endocannabinoid Levels at Birth and Induces Overweight and Increased Adiposity at Adulthood in Male Rat Offspring. Front Behav Neurosci. 2016; 10:208
Abstract: Exposure to inadequate nutritional conditions in critical windows of development has been associated to disturbances on metabolism and behavior in the offspring later in life. The role of the endocannabinoid system, a known regulator of energy expenditure and adaptive behaviors, in the modulation of these processes is unknown. In the present study, we investigated the impact of exposing rat dams to diet restriction (20% less calories than standard diet) during pre-gestational and gestational periods on: (a) neonatal outcomes; (b) endocannabinoid content in hypothalamus, hippocampus and olfactory bulb at birth; (c) metabolism-related parameters; and (d) behavior in adult male offspring. We found that calorie-restricted dams tended to have a reduced litter size, although the offspring showed normal weight at birth. Pups from calorie-restricted dams also exhibited a strong decrease in the levels of anandamide (AEA), 2-arachidonoylglycerol (2-AG), arachidonic acid (AA) and palmitoylethanolamide (PEA) in the hypothalamus at birth. Additionally, pups from diet-restricted dams displayed reduced levels of AEA in the hippocampus without significant differences in the olfactory bulb. Moreover, offspring exhibited increased weight gain, body weight and adiposity in adulthood as well as increased anxiety-related responses. We propose that endocannabinoid signaling is altered by a maternal caloric restriction implemented during the preconceptional and pregnancy periods, which might lead to modifications of the hypothalamic and hippocampal circuits, potentially contributing to the long-term effects found in the adult offspring.
Descripción : Journal Article;
URI: http://hdl.handle.net/10668/2561
Versión del editor : http://journal.frontiersin.org/article/10.3389/fnbeh.2016.00208/full
DOI: 10.3389/fnbeh.2016.00208
ISSN : 1662-5153 (Online)
Appears in Collections:01- Artículos - IBIMA. Instituto de Investigación Biomédica de Málaga
01- Artículos - Hospital Regional de Málaga

Files in This Item:
File Description SizeFormat 
RamirezLopezMT_MaternalCaloricRestriction.pdfArtículo publicado2,58 MBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons