Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/2598
Título : Low phase angle is associated with the development of hepatic encephalopathy in patients with cirrhosis.
Autor : Ruiz-Margáin, Astrid
Macías-Rodríguez, Ricardo Ulises
Ampuero, Javier
Cubero, Francisco Javier
Chi-Cervera, Luis
Ríos-Torres, Silvia L
Duarte-Rojo, Andrés
Espinosa-Cuevas, Ángeles
Romero-Gómez, Manuel
Torre, Aldo
Filiación: [Ruiz-Margáin,A; Macías-Rodríguez,RU] Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México City, México. Department of Internal Medicine Ⅲ, University Hospital RWTH Aachen, Aachen, Germany. [Ampuero,J; Romero-Gómez,M] Unit for the Clinical Management of Digestive Diseases, Virgen del Rocio -Virgen Macarena University Hospital, Sevilla, Spain. [Cubero,FJ] Department of Immunology, Complutense University School of Medicine, Madrid, Spain. [Chi-Cervera,L; Ríos-Torres,SL; Torre,A] Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México City, México. [Duarte-Rojo,A] University of Arkansas for Medical Sciences, Little Rock, United States. [Espinosa-Cuevas,A] Department of Nephrology and Mineral Merabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México City, México.
Palabras clave : Malnutrition
Hepatic encephalopathy
Phase angle
Cachexia
Prognosis
Estudios de seguimiento
Várices esofágicas y gástricas
Encefalopatía hepática
Hepatitis C
Cirrosis hepática
Modelos de riesgos proporcionales
Análisis de regresión
MeSH: Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Body Weight::Body Weight Changes::Weight Loss::Emaciation::Cachexia
Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Azoles::Imidazoles::Creatinine
Medical Subject Headings::Diseases::Digestive System Diseases::Gastrointestinal Diseases::Esophageal Diseases::Esophageal and Gastric Varices
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Follow-Up Studies
Medical Subject Headings::Diseases::Digestive System Diseases::Gastrointestinal Diseases::Gastrointestinal Hemorrhage
Medical Subject Headings::Diseases::Digestive System Diseases::Liver Diseases::Hepatic Insufficiency::Liver Failure::Hepatic Encephalopathy
Medical Subject Headings::Diseases::Virus Diseases::Hepatitis, Viral, Human::Hepatitis C::Hepatitis C, Chronic
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Incidence
Medical Subject Headings::Diseases::Digestive System Diseases::Liver Diseases::Liver Cirrhosis
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Analysis of Variance::Multivariate Analysis
Medical Subject Headings::Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Epidemiologic Factors::Causality::Precipitating Factors
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models, Statistical::Proportional Hazards Models
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective Studies
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Regression Analysis
Fecha de publicación : 7-Dec-2016
Editorial : Baishideng Publishing Group
Cita Bibliográfica: Ruiz-Margáin A, Macías-Rodríguez RU, Ampuero J, Cubero FJ, Chi-Cervera L, Ríos-Torres SL, et al. Low phase angle is associated with the development of hepatic encephalopathy in patients with cirrhosis. World J. Gastroenterol.. 2016; 22(45):10064-10070
Abstract: AIM Evaluate the association between phase angle and the development of hepatic encephalopathy in the long-term follow-up of cirrhotic patients. METHODS This was a prospective cohort study. Clinical, nutritional and biochemical evaluations were performed. Mann-Whitney's U and χ(2) tests were used as appropriate. Kaplan-Meier curves and Cox proportional Hazards analysis were used to evaluate the prediction and incidence of hepatic encephalopathy. RESULTS Two hundred and twenty were included; the most frequent etiology of cirrhosis was hepatitis C infection, 52% of the patients developed hepatic encephalopathy (18.6% covert and 33.3% overt); the main precipitating factors were infections and variceal bleeding. Kaplan-Meier curves showed a higher proportion of HE in the group with low phase angle (39%) compared to the normal phase angle group (13%) (P = 0.012). Furthermore, creatinine and phase angle remained independently associated to hepatic encephalopathy in the Cox regression multivariate analysis [hazard ratio = 1.80 (1.07-3.03)]. CONCLUSION In our cohort of patients low phase angle was associated with an increased incidence of hepatic encephalopathy. Phase angle is a useful nutritional marker that evaluates cachexia and could be used as a part of the integral assessment in patients with cirrhosis.
Descripción : Journal Article;
URI: http://hdl.handle.net/10668/2598
Versión del editor : http://www.wjgnet.com/1007-9327/full/v22/i45/10064.htm
DOI: 10.3748/wjg.v22.i45.10064
ISSN : 2219-2840 (Online)
1007-9327 (Print)
Appears in Collections:01- Artículos - Hospital Virgen del Rocío
01- Artículos - Hospital Virgen Macarena

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